{"id":"https://openalex.org/W2431978283","doi":null,"title":"Expression of mouse serotonin transporter RNA in Xenopus laevis oocytes.","display_name":"Expression of mouse serotonin transporter RNA in Xenopus laevis oocytes.","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2431978283","mag":"2431978283","pmid":"https://pubmed.ncbi.nlm.nih.gov/1845527"},"language":"en","primary_location":{"id":"pmid:1845527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1845527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009020340","display_name":"Roberta Haber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Haber","raw_affiliation_strings":["Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892","Laboratory of Clinical Studies, National Institute on Alcohol Abuse & Alcoholism, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210121815"]},{"raw_affiliation_string":"Laboratory of Clinical Studies, National Institute on Alcohol Abuse & Alcoholism, Bethesda, MD 20892","institution_ids":["https://openalex.org/I4210121815"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041766549","display_name":"David A Goldman","orcid":"https://orcid.org/0000-0002-1724-5405","observed_orcids":["https://orcid.org/0000-0002-1724-5405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Goldman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17963105,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":null,"first_page":"125","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.22499999403953552,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":1.0},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.640999972820282},{"id":"https://openalex.org/keywords/xenopus-oocyte-expression-system","display_name":"Xenopus oocyte expression","score":0.7179999947547913},{"id":"https://openalex.org/keywords/citalopram","display_name":"citalopram","score":0.7689999938011169},{"id":"https://openalex.org/keywords/serotonin-uptake-inhibition","display_name":"serotonin uptake inhibition","score":0.8899999856948853},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":0.6859999895095825},{"id":"https://openalex.org/keywords/neurotransmitter-reuptake","display_name":"neurotransmitter reuptake","score":0.7639999985694885}],"concepts":[{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.8606083393096924},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.8551182746887207},{"id":"https://openalex.org/C16696662","wikidata":"https://www.wikidata.org/wiki/Q17079236","display_name":"Neurotransmitter transporter","level":4,"score":0.8147022724151611},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.7884993553161621},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5920706391334534},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.5879572033882141},{"id":"https://openalex.org/C2908747647","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"Serotonin Plasma Membrane Transport Proteins","level":5,"score":0.5875713229179382},{"id":"https://openalex.org/C2993285035","wikidata":"https://www.wikidata.org/wiki/Q2643251","display_name":"Synaptic cleft","level":4,"score":0.4902525246143341},{"id":"https://openalex.org/C2777490545","wikidata":"https://www.wikidata.org/wiki/Q409672","display_name":"Citalopram","level":4,"score":0.46833372116088867},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.455817848443985},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4335760176181793},{"id":"https://openalex.org/C99631742","wikidata":"https://www.wikidata.org/wiki/Q22290476","display_name":"Reuptake","level":4,"score":0.425568163394928},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40057623386383057},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3928796947002411},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3550652861595154},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2682924270629883},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1216931939125061},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11226952075958252},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08902877569198608},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05235084891319275}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015283","descriptor_name":"Citalopram","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050486","descriptor_name":"Serotonin Plasma Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1845527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1845527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcohol and alcoholism (Oxford, Oxfordshire). Supplement","raw_type":"Journal Article"},{"id":"mag:2431978283","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1845527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2022332481","https://openalex.org/W2073566204","https://openalex.org/W2066744043","https://openalex.org/W3106093870","https://openalex.org/W2164685973","https://openalex.org/W2027223239","https://openalex.org/W2019351878","https://openalex.org/W4255798002","https://openalex.org/W33182912","https://openalex.org/W3099568273"],"abstract_inverted_index":{"The":[0],"serotonin":[1,4,23,42,64,75],"transporter":[2,24,43,50],"removes":[3],"from":[5],"the":[6,9,22,49],"synapse,":[7],"terminating":[8],"action":[10],"of":[11,41,48,62,74],"this":[12],"neurotransmitter.":[13],"We":[14,32],"have":[15],"taken":[16],"an":[17],"initial":[18],"step":[19],"towards":[20],"cloning":[21],"by":[25,67],"obtaining":[26],"its":[27],"expression":[28],"in":[29,51],"Xenopus":[30],"oocytes.":[31],"found":[33],"that":[34,46],"mouse":[35],"brainstem":[36],"is":[37],"a":[38,57,71],"suitable":[39],"source":[40],"mRNA":[44],"and":[45],"synthesis":[47],"injected":[52],"oocytes":[53],"occurs":[54],"steadily":[55],"over":[56],"3":[58],"day":[59],"period.":[60],"Uptake":[61],"[3H]":[63],"was":[65],"inhibited":[66],"18":[68],"nM":[69],"citalopram,":[70],"specific":[72],"inhibitor":[73],"transport.":[76]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}