{"id":"https://openalex.org/W2431911065","doi":null,"title":"Anti-HLA-E monoclonal antibodies reacting with HLA-la and lb alleles like IVIg as potential IVIg-immunomimetics: an evolving therapeutic concept.","display_name":"Anti-HLA-E monoclonal antibodies reacting with HLA-la and lb alleles like IVIg as potential IVIg-immunomimetics: an evolving therapeutic concept.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2431911065","mag":"2431911065","pmid":"https://pubmed.ncbi.nlm.nih.gov/25095521"},"language":"en","primary_location":{"id":"pmid:25095521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25095521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical transplants","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058308355","display_name":"Mepur H. Ravindranath","orcid":"https://orcid.org/0000-0002-5731-4129","observed_orcids":["https://orcid.org/0000-0002-5731-4129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mepur H Ravindranath","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101727835","display_name":"Dong Zhu","orcid":"https://orcid.org/0000-0002-1152-1624","observed_orcids":["https://orcid.org/0000-0002-1152-1624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dong Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Tho Pham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tho Pham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046486757","display_name":"Vadim Jucaud","orcid":"https://orcid.org/0000-0003-0385-2623","observed_orcids":["https://orcid.org/0000-0003-0385-2623"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vadim Jucaud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051962730","display_name":"Judy Hopfield","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Judy Hopfield","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065379521","display_name":"Satoru Kawakita","orcid":"https://orcid.org/0000-0002-3781-5786","observed_orcids":["https://orcid.org/0000-0002-3781-5786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoru Kawakita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111872318","display_name":"Paul I. Terasaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul I Terasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0328,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.77352608,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"293","last_page":"305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.23849999904632568,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.054499998688697815,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-e","display_name":"HLA-E","score":0.8180000185966492},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.8199999928474426},{"id":"https://openalex.org/keywords/alloimmunization","display_name":"alloimmunization","score":0.859000027179718},{"id":"https://openalex.org/keywords/cd4-t-cell-suppression","display_name":"CD4+ T cell suppression","score":0.8130000233650208},{"id":"https://openalex.org/keywords/b-cell-suppression","display_name":"B cell suppression","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7757775783538818},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.7381680011749268},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6991103887557983},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6962320804595947},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5847693681716919},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4789905250072479},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.4689841866493225},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3700997829437256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20779874920845032}],"mesh":[{"descriptor_ui":"D000097625","descriptor_name":"HLA-E Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014181","descriptor_name":"Transplantation Immunology","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016756","descriptor_name":"Immunoglobulins, Intravenous","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016756","descriptor_name":"Immunoglobulins, Intravenous","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25095521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25095521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical transplants","raw_type":"Journal Article"},{"id":"mag:2431911065","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25095521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.800000011920929}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2618527828","https://openalex.org/W1757142253","https://openalex.org/W2773655390","https://openalex.org/W1991809449","https://openalex.org/W3161689758","https://openalex.org/W1564887779","https://openalex.org/W2319232804","https://openalex.org/W2034495556","https://openalex.org/W4214915756","https://openalex.org/W2088370127"],"abstract_inverted_index":{"Healthy":[0],"individuals":[1],"have":[2,123],"natural":[3],"antibodies":[4,80],"(Abs)":[5],"reacting":[6],"to":[7,16,27,48,107,126,182],"allo-human":[8],"leukocyte":[9],"antigen":[10],"(HLA)-la.":[11],"This":[12],"could":[13],"be":[14],"due":[15],"the":[17,29,61,67,109,115,124,128,143,147,164,177,195,199,208,214],"presence":[18],"of":[19,43,56,102,130,135,202,210],"anti-HLA-E":[20,62,73],"immunoglobulin":[21],"G":[22],"(IgG),":[23],"which":[24,104],"was":[25,179],"revealed":[26],"recognize":[28],"peptides":[30],"shared":[31],"between":[32],"HLA-E":[33,95],"and":[34,84,114,133,194],"HLA-la":[35,76,99],"after":[36],"peptide":[37],"inhibition":[38],"assay.":[39],"Sera":[40],"or":[41],"plasma":[42],"multiple":[44],"donors":[45],"are":[46,64,204],"pooled":[47],"prepare":[49],"intravenous":[50],"immune":[51],"globulin":[52],"(IVIg).":[53],"The":[54],"HLA-la-reactivity":[55],"IVIg":[57,71,139,193,211],"is":[58,105,140],"abolished":[59],"when":[60],"Abs":[63,74,132],"depleted":[65],"from":[66,93,155],"IVIg,":[68,103],"suggesting":[69],"that":[70,183],"contains":[72],"with":[75],"reactivity.":[77],"Anti-HLA-E":[78],"monoclonal":[79],"(mAbs;":[81],"e.g.,":[82],"TFL-006":[83],"TFL-007)":[85],"generated":[86],"at":[87],"Terasaki":[88],"Foundation":[89],"Laboratory":[90],"(TFL)":[91],"differ":[92],"commercial":[94],"mAbs":[96],"in":[97],"mimicking":[98],"&-lb":[100],"reactivities":[101],"known":[106],"suppress":[108,127],"allo-HLA":[110],"antibody":[111],"(Ab)":[112],"production":[113,129,150],"activated":[116],"CD4+":[117],"T":[118,136,187],"cells.":[119],"Whether":[120],"HLA-E-mAbs":[121],"also":[122],"ability":[125],"these":[131],"activation":[134],"cells":[137,153,188],"like":[138],"evaluated.":[141],"Indeed,":[142],"TFL-mAbs":[144,165,196,203],"significantly":[145],"suppressed":[146,166,190],"allo-HLA-ll":[148],"Ab":[149,168],"by":[151,170,184,191],"B":[152],"obtained":[154],"a":[156,171],"woman":[157],"alloimmunized":[158],"postpartum":[159],">20":[160],"years":[161],"ago.":[162],"Similarly,":[163],"HLA-I":[167],"produced":[169],"B-cell":[172],"hybridoma.":[173],"In":[174],"both":[175,192],"instances,":[176],"suppression":[178],"far":[180],"superior":[181],"IVIg.":[185],"Activated":[186],"were":[189],"dosimetrically.":[197],"Furthermore,":[198],"required":[200,212],"concentrations":[201,209],"150-fold":[205],"lower":[206],"than":[207],"for":[213],"suppression.":[215]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}