{"id":"https://openalex.org/W2431855950","doi":null,"title":"Mdr1 mRNA expression differs between grade III astrocytomas and glioblastomas.","display_name":"Mdr1 mRNA expression differs between grade III astrocytomas and glioblastomas.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2431855950","mag":"2431855950","pmid":"https://pubmed.ncbi.nlm.nih.gov/9020393"},"language":"en","primary_location":{"id":"pmid:9020393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9020393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neuropathology","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083797096","display_name":"Elmar Kirches","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E Kirches","raw_affiliation_strings":["Institut f\u00fcr Neuropathologie, Universit\u00e4t Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Neuropathologie, Universit\u00e4t Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049884976","display_name":"Yoshinao Oda","orcid":"https://orcid.org/0000-0001-9636-1182","observed_orcids":["https://orcid.org/0000-0001-9636-1182"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Oda","raw_affiliation_strings":["Pathobiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathobiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025704460","display_name":"Peter von Bossanyi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P Von Bossanyi","raw_affiliation_strings":["Otto-von-Guericke-University, Magdeburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otto-von-Guericke-University, Magdeburg","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005927227","display_name":"Sabine Diete","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S Diete","raw_affiliation_strings":["Otto-von-Guericke-University, Magdeburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otto-von-Guericke-University, Magdeburg","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056753690","display_name":"Thomas L. Schneider","orcid":"https://orcid.org/0000-0001-8947-0911","observed_orcids":["https://orcid.org/0000-0001-8947-0911"]},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Schneider","raw_affiliation_strings":["Otto-von-Guericke-University, Magdeburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otto-von-Guericke-University, Magdeburg","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073112013","display_name":"Michaela Warich-Kirches","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Warich-Kirches","raw_affiliation_strings":["Otto-von-Guericke-University, Magdeburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otto-von-Guericke-University, Magdeburg","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113754472","display_name":"Knut Dietzmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K Dietzmann","raw_affiliation_strings":["Otto-von-Guericke-University, Magdeburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otto-von-Guericke-University, Magdeburg","institution_ids":["https://openalex.org/I95793202"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6068,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.71493327,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"16","issue":"1","first_page":"34","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mdr1","display_name":"MDR1","score":0.7919999957084656},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.796999990940094},{"id":"https://openalex.org/keywords/anaplastic-astrocytoma","display_name":"anaplastic astrocytoma","score":0.9100000262260437},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-grading","display_name":"tumor grading","score":0.8629999756813049},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7799999713897705},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.6859999895095825},{"id":"https://openalex.org/keywords/nimustine","display_name":"ACNU","score":0.7300000190734863},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C2779083369","wikidata":"https://www.wikidata.org/wiki/Q486092","display_name":"Anaplastic astrocytoma","level":4,"score":0.8592067956924438},{"id":"https://openalex.org/C2778880634","wikidata":"https://www.wikidata.org/wiki/Q177755","display_name":"Astrocytoma","level":3,"score":0.820791482925415},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7950314283370972},{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.7121483087539673},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5519683361053467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5452634692192078},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5426459908485413},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.5424126386642456},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4784831404685974},{"id":"https://openalex.org/C21957315","wikidata":"https://www.wikidata.org/wiki/Q287896","display_name":"Beta-2 microglobulin","level":2,"score":0.44364774227142334},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3337146043777466},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30192017555236816},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27801650762557983},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21954303979873657},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9020393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9020393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical neuropathology","raw_type":"Comparative Study"},{"id":"mag:2431855950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9020393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2400833483","https://openalex.org/W2388277128","https://openalex.org/W1546606332","https://openalex.org/W7099133011","https://openalex.org/W296294136","https://openalex.org/W2079354361","https://openalex.org/W7132165818","https://openalex.org/W2409233607","https://openalex.org/W2415414090","https://openalex.org/W2119526706"],"abstract_inverted_index":{"104":[0],"N2-frozen":[1],"samples":[2,127,141],"from":[3,149],"33":[4],"astrocytic":[5],"tumors":[6],"previously":[7],"untreated":[8],"with":[9,73,107,128],"cytotoxic":[10],"drugs":[11,186],"have":[12],"been":[13],"analyzed":[14],"for":[15],"the":[16,43,51,61,81,87,102,108,113,122,126,129,137,160,185],"expression":[17,132],"of":[18,42,53,60,70,86,159,166,181,184],"p-glycoprotein":[19],"transcripts":[20],"(mdrl)":[21],"by":[22],"RT-PCR":[23],"using":[24],"beta2-microglobulin":[25],"as":[26],"an":[27,91],"internal":[28],"control.":[29],"A":[30],"remarkable":[31],"variation":[32],"was":[33,80,168],"observed":[34,169],"even":[35,178],"within":[36],"a":[37,46,68,74,95,156],"single":[38],"tumor":[39,99,103,150],"in":[40,84,152,170,192],"50%":[41],"cases.":[44],"Nevertheless,":[45],"difference":[47],"became":[48],"visible":[49],"between":[50,98,121],"groups":[52,124],"anaplastic":[54],"astrocytomas":[55,64],"and":[56,101,188],"glioblastomas.":[57,88],"While":[58],"78%":[59],"grade":[62],"3":[63],"contained":[65],"at":[66],"least":[67],"minimum":[69],"1":[71],"sample":[72],"very":[75],"low":[76],"mdr1":[77,131,167],"expression,":[78],"this":[79],"case":[82],"only":[83],"23%":[85],"This":[89],"supports":[90],"earlier":[92],"observation":[93],"revealing":[94],"positive":[96],"correlation":[97],"grading":[100],"cell":[104,176],"fraction":[105,158],"stained":[106],"monoclonal":[109],"antibody":[110],"JSB1.":[111],"On":[112],"other":[114],"hand,":[115],"no":[116],"major":[117],"differences":[118],"were":[119,133],"found":[120],"histological":[123],"when":[125],"highest":[130],"selected":[134],"to":[135],"represent":[136],"individual":[138],"tumors.":[139],"Those":[140],"are":[142],"less":[143],"informative.":[144],"They":[145],"might":[146],"be":[147],"derived":[148],"regions":[151],"which":[153],"capillaries":[154],"deliver":[155],"larger":[157],"total":[161],"mRNA":[162],"pool.":[163],"No":[164],"induction":[165],"some":[171],"early":[172],"astrocytoma":[173],"or":[174],"glioblastoma":[175],"cultures":[177],"after":[179],"administration":[180],"high":[182],"concentrations":[183],"ACNU":[187],"VM26,":[189],"often":[190],"used":[191],"glioma":[193],"therapy.":[194]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}