{"id":"https://openalex.org/W2431813866","doi":null,"title":"[Relevance of Endoglin (CD105) VEGF and p53 with invasion metastasis and prognosis of laryngeal carcinoma].","display_name":"[Relevance of Endoglin (CD105) VEGF and p53 with invasion metastasis and prognosis of laryngeal carcinoma].","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W2431813866","mag":"2431813866","pmid":"https://pubmed.ncbi.nlm.nih.gov/18330257"},"language":"zh","primary_location":{"id":"pmid:18330257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18330257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101607288","display_name":"Qingming Li","orcid":"https://orcid.org/0000-0001-5991-5086","observed_orcids":["https://orcid.org/0000-0001-5991-5086"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingming Li","raw_affiliation_strings":["Department of Otorhinolaryngology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. laryngologyzhang@yahoo.com.cn","Department of Otorhinolaryngology\uff0cNanfang Hospital,Southern Medical University,Guangzhou, 510515,China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. laryngologyzhang@yahoo.com.cn","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of Otorhinolaryngology\uff0cNanfang Hospital,Southern Medical University,Guangzhou, 510515,China","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Baoquan Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Baoquan Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Peihong Peng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peihong Peng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3749,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.64488636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"21","issue":"24","first_page":"1114","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.8560000061988831,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.8560000061988831,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.1404999941587448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laryngeal-cancer","display_name":"laryngeal cancer","score":0.7940000295639038},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.8040000200271606},{"id":"https://openalex.org/keywords/endoglin","display_name":"CD105","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9610000252723694},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9850000143051147},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.859000027179718},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.5389999747276306},{"id":"https://openalex.org/keywords/invasion","display_name":"invasion","score":0.45500001311302185},{"id":"https://openalex.org/keywords/tnm-stage","display_name":"TNM stage","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.6029999852180481},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.31299999356269836},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.597000002861023},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.722000002861023},{"id":"https://openalex.org/keywords/tumor-suppressor-proteins","display_name":"tumor suppressor proteins","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C6061869","wikidata":"https://www.wikidata.org/wiki/Q18250377","display_name":"Endoglin","level":4,"score":0.9866361618041992},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6094805598258972},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5828043222427368},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5710946321487427},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.526941180229187},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5214269161224365},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4335659444332123},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.42844006419181824},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.41409942507743835},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.41291409730911255},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2605907917022705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2111228108406067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19585829973220825},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18848422169685364},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0679885745048523},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.05220791697502136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071063","descriptor_name":"Endoglin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18330257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18330257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery","raw_type":"Journal Article"},{"id":"mag:2431813866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18330257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2386891549","https://openalex.org/W2361429940","https://openalex.org/W2016068284","https://openalex.org/W2371544905","https://openalex.org/W2365824785","https://openalex.org/W1969775342","https://openalex.org/W2384053797","https://openalex.org/W2380793197","https://openalex.org/W2070145126","https://openalex.org/W2352710611"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2,294],"the":[3,12],"clinical":[4,25],"significance":[5,23],"of":[6,14,24,34,42,111,123,132,141,151,157,179,187,195,210,248,273,282,299],"microvessel":[7],"density":[8,65],"(MVD)":[9,66],"and":[10,18,21,31,55,59,113,125,160,176,198,219,234,277,279,287,297],"investigate":[11],"relationship":[13],"Endoglin":[15,52,69,79,100,243],"(CD105),":[16,53],"VEGF":[17,54,152,220,286],"p53":[19,56,188,235,288],"protein":[20,189],"their":[22],"pathology.":[26],"METHOD:":[27],"Pathologic":[28],"paraffin-embedded":[29],"tissues":[30],"clinic":[32],"data":[33],"40":[35],"patients":[36],"with":[37,51,134,143,173,208,255],"primary":[38],"squamous":[39],"cell":[40,159,197],"carcinoma":[41,181,268],"larynx":[43],"were":[44,48,62,71],"studied.":[45],"Serial":[46],"sections":[47],"respectively":[49],"stained":[50],"by":[57,68],"immunohistochemistry":[58],"its":[60,161,199,252],"expressions":[61],"investigated.":[63],"Microvessel":[64],"highlighted":[67],"(CD105)":[70,80,101,244],"counted":[72],"according":[73],"to":[74,293],"a":[75,117,246],"standard":[76],"protocol.":[77],"RESULT:":[78],"expression":[81,150,186],"in":[82,89,155,166,193,258,266],"tumour":[83,158,196,249],"tissue":[84],"was":[85,102,136,153,164,170,190,202,205,215,229],"significantly":[86,118,171,206],"higher":[87,119,138],"than":[88,121,139],"normal":[90],"mucosa":[91],"(P":[92,146,182],"<":[93,147,183,225,240],"0.05).":[94,184],"The":[95,107,128,149,185,261],"mean":[96,108,129],"MVD":[97],"value":[98,110,131],"for":[99,251],"14.":[103],"90":[104],"+/-":[105],"7.40.":[106],"CD105-MVD":[109,130,218,233,265],"T3":[112],"T4":[114],"tumours":[115,133,142],"showed":[116],"staining":[120],"that":[122,140,264],"T1":[124],"T2":[126],"tumours;":[127],"metastasis":[135,145,209,276,296],"also":[137,230],"no":[144],"0.05);":[148],"observed":[154,192],"cytoplasm":[156],"positive":[162,200],"rate":[163,201],"77.5%":[165],"laryngeal":[167,180,259,267,300],"carcinoma,":[168],"which":[169,204],"correlated":[172,207],"TNM":[174],"stage":[175],"pathological":[177],"differentiation":[178],"mainly":[191],"nucleolus":[194],"67.5%,":[203],"lymph":[211],"node.":[212],"Positive":[213,227],"relevance":[214,228],"found":[216,231],"between":[217,232],"(r":[221,236],"=":[222,237],"0.641,":[223],"P":[224,239],"0.01);":[226],"0.534,":[238],"0.01).":[241],"CONCLUSION:":[242],"is":[245,269],"marker":[247],"angiogenesis":[250,257],"significant":[253],"associated":[254],"active":[256],"carcinoma.":[260,301],"study":[262],"shows":[263],"an":[270],"independent":[271],"indicator":[272],"predicting":[274],"invasion,":[275,295],"recurrence,":[278],"evaluating":[280],"prognosis":[281],"malignant":[283],"tumours.":[284],"CD105-MVD,":[285],"could":[289],"be":[290],"important":[291],"indicators":[292],"recurrence":[298]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}