{"id":"https://openalex.org/W2431662865","doi":null,"title":"Rapidly Progressive Seeding of a Community Acquired Pathogen in an Immune-competent Host--End Organ Damage from Head to Bone.","display_name":"Rapidly Progressive Seeding of a Community Acquired Pathogen in an Immune-competent Host--End Organ Damage from Head to Bone.","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W2431662865","mag":"2431662865","pmid":"https://pubmed.ncbi.nlm.nih.gov/26434076"},"language":"en","primary_location":{"id":"pmid:26434076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26434076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Boletin de la Asociacion Medica de Puerto Rico","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003563429","display_name":"Daisy Torres-Miranda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daisy Torres-Miranda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018449415","display_name":"Farah Al\u2010Saffar","orcid":"https://orcid.org/0000-0002-0133-3726","observed_orcids":["https://orcid.org/0000-0002-0133-3726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farah Al-Saffar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023368357","display_name":"Saif Ibrahim","orcid":"https://orcid.org/0000-0003-1565-7243","observed_orcids":["https://orcid.org/0000-0003-1565-7243"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saif Ibrahim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016500539","display_name":"Stephanie Diaz-Font","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie Font-Diaz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.2798761,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"107","issue":"2","first_page":"20","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methicillin-susceptible-staphylococcus-aureus","display_name":"methicillin-susceptible Staphylococcus aureus","score":0.9850000143051147},{"id":"https://openalex.org/keywords/bacteremia","display_name":"bacteremia","score":0.6919999718666077},{"id":"https://openalex.org/keywords/infective-endocarditis","display_name":"infective endocarditis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/septic-emboli","display_name":"septic emboli","score":0.6480000019073486},{"id":"https://openalex.org/keywords/meningitis","display_name":"meningitis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.6629999876022339},{"id":"https://openalex.org/keywords/osteomyelitis","display_name":"osteomyelitis","score":0.878000020980835},{"id":"https://openalex.org/keywords/multiple-organ-failure","display_name":"multiple organ failure","score":0.675000011920929},{"id":"https://openalex.org/keywords/community-acquired-infections","display_name":"community-acquired infections","score":0.7390000224113464},{"id":"https://openalex.org/keywords/immune-competent-host","display_name":"immune-competent host","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mitral-valve-vegetation","display_name":"mitral valve vegetation","score":0.5720000267028809},{"id":"https://openalex.org/keywords/renal-abscess","display_name":"renal abscess","score":0.4449999928474426},{"id":"https://openalex.org/keywords/pulmonary-cavities","display_name":"pulmonary cavities","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8653604984283447},{"id":"https://openalex.org/C2780176578","wikidata":"https://www.wikidata.org/wiki/Q2450598","display_name":"Infective endocarditis","level":2,"score":0.657350480556488},{"id":"https://openalex.org/C2777693794","wikidata":"https://www.wikidata.org/wiki/Q1744036","display_name":"Transesophageal echocardiogram","level":2,"score":0.6038827896118164},{"id":"https://openalex.org/C2781026528","wikidata":"https://www.wikidata.org/wiki/Q48143","display_name":"Meningitis","level":2,"score":0.5687536001205444},{"id":"https://openalex.org/C2775872228","wikidata":"https://www.wikidata.org/wiki/Q82504","display_name":"Endocarditis","level":2,"score":0.5650184154510498},{"id":"https://openalex.org/C2777682441","wikidata":"https://www.wikidata.org/wiki/Q7835379","display_name":"Transthoracic echocardiogram","level":2,"score":0.5309212803840637},{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.4989452362060547},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4679640233516693},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4626624882221222},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.31350088119506836},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007121","descriptor_name":"Immunocompetence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009254","descriptor_name":"Nafcillin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010019","descriptor_name":"Osteomyelitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010019","descriptor_name":"Osteomyelitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010019","descriptor_name":"Osteomyelitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010291","descriptor_name":"Paresis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016920","descriptor_name":"Meningitis, Bacterial","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D016920","descriptor_name":"Meningitis, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016920","descriptor_name":"Meningitis, Bacterial","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016920","descriptor_name":"Meningitis, Bacterial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017548","descriptor_name":"Echocardiography, Transesophageal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017714","descriptor_name":"Community-Acquired Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017714","descriptor_name":"Community-Acquired Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D017714","descriptor_name":"Community-Acquired Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019918","descriptor_name":"Heart Valve Prosthesis Implantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D057915","descriptor_name":"Drug Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:26434076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26434076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Boletin de la Asociacion Medica de Puerto Rico","raw_type":"Case Reports"},{"id":"mag:2431662865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26434076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1593524714","https://openalex.org/W7164976863","https://openalex.org/W2317733890","https://openalex.org/W3005823620","https://openalex.org/W2885900694","https://openalex.org/W7161563133","https://openalex.org/W4417143795","https://openalex.org/W2501860013","https://openalex.org/W2768418174","https://openalex.org/W2976187690"],"abstract_inverted_index":{"This":[0],"report":[1],"describes":[2],"a":[3,13,87,132,145,150,158,174,193,199],"64-years-old":[4],"male":[5],"patient":[6,74,194],"that":[7,182],"presented":[8],"to":[9,39,170,215,239],"our":[10,240],"hospital":[11],"with":[12,95,131,227],"chief":[14],"complaint":[15],"of":[16,19,68,86,149,176,179,201,252],"acute":[17,77],"worsening":[18],"his":[20],"usual":[21],"chronic":[22],"lower":[23,29],"back":[24],"pain,":[25],"progressive":[26,152],"weakness":[27],"in":[28,167,184,192],"extremities":[30],"and":[31,51,82,127,189,225,230,257],"subjective":[32],"fevers":[33],"at":[34,109],"home.":[35],"Spine":[36],"CT":[37],"failed":[38],"demonstrate":[40],"any":[41],"infectious":[42],"foci":[43],"but":[44],"showed":[45,65,84,102],"partially":[46],"visualized":[47],"lung":[48],"cavitary":[49],"lesion":[50],"renal":[52],"pole":[53],"abnormalities.":[54],"Blood":[55],"cultures":[56],"grew":[57],"methicillin-sensitive":[58],"Staphylococcus":[59],"Aureus":[60],"(MSSA).":[61],"Transthoracic":[62],"echocardiogram":[63,119],"(TTE)":[64],"no":[66,244],"signs":[67],"infective":[69],"endocarditis":[70,186],"(IE).":[71],"Later,":[72],"the":[73,168,219],"experienced":[75],"an":[76,250],"deterioration":[78],"on":[79,138],"clinical":[80],"status":[81],"examination":[83],"development":[85],"new":[88,93,124],"murmur.":[89],"He":[90],"also":[91],"developed":[92],"hemiparesis":[94],"up-going":[96],"babinski":[97],"reflex.":[98],"A":[99,117],"head":[100],"MRI":[101,105],"multiple":[103],"infarcts.":[104],"spine":[106,222],"displayed":[107],"osteomyelitis":[108],"T12-L1.":[110],"Cerebro-spinal":[111],"fluid":[112],"was":[113,121,210],"positive":[114],"for":[115],"meningitis.":[116],"transesophageal":[118],"(TEE)":[120],"performed":[122],"demonstrating":[123],"severe":[125],"mitral":[126,140],"mild":[128],"tricuspid":[129],"regurgitations":[130],"definitive":[133],"1.5":[134],"cm":[135],"mobile":[136],"vegetation":[137],"posterior":[139],"leaflet.":[141],"We":[142,172],"present":[143],"is":[144,157],"very":[146],"interesting":[147],"case":[148,175,209,246],"rapidly":[151],"MSSA":[153,155,177,185,234],"infection.":[154],"meningitis":[156,229,256],"rare":[159],"disease;":[160],"there":[161,242],"are":[162,236,243,261],"only":[163],"few":[164],"reported":[165],"cases":[166],"literature":[169],"date.":[171],"describe":[173],"bacteremia,":[178],"questionable":[180],"source,":[181],"resulted":[183],"affecting":[187],"right":[188],"left":[190],"heart":[191],"who":[195],"did":[196],"not":[197],"have":[198],"history":[200],"intravenous":[202],"drug":[203],"use":[204],"(IVDU)":[205],"or":[206],"immunosuppression.":[207],"The":[208],"complicated":[211],"by":[212],"septic":[213],"emboli":[214],"systemic":[216],"circulation":[217],"involving":[218],"kidneys,":[220],"vertebral":[221],"(osteomyelitis),":[223],"lungs":[224],"brain":[226],"consequent":[228],"stroke.":[231,258],"Even":[232],"when":[233],"infections":[235],"well":[237],"known,":[238],"knowledge":[241],"previous":[245],"reports":[247],"describing":[248],"such":[249],"acute-simultaneous-manifestation":[251],"multi-end-organ":[253],"failure,":[254],"including":[255],"These":[259],"latter":[260],"rarely":[262],"reported,":[263],"even":[264],"individually.":[265]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}