{"id":"https://openalex.org/W2431363408","doi":null,"title":"Characterization of afferent mechanisms in ileoanal pouches.","display_name":"Characterization of afferent mechanisms in ileoanal pouches.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2431363408","mag":"2431363408","pmid":"https://pubmed.ncbi.nlm.nih.gov/8995947"},"language":"en","primary_location":{"id":"pmid:8995947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8995947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043194749","display_name":"Bernstein Cn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C N Bernstein","raw_affiliation_strings":["Department of Medicine, University of Manitoba, Winnipeg, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Manitoba, Winnipeg, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017544636","display_name":"Rolando Rollandelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Rollandelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111315080","display_name":"Nasreen Hassan Niazi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Niazi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Robert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Robert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074817278","display_name":"T Hirsh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Hirsh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108561556","display_name":"J. Munakata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Munakata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110415157","display_name":"EA Mayer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E A Mayer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2731,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.55635413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"92","issue":"1","first_page":"103","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8931000232696533,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ileoanal-pouch","display_name":"ileoanal pouch","score":0.9760000109672546},{"id":"https://openalex.org/keywords/afferent-innervation","display_name":"afferent innervation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/visceral-perception","display_name":"visceral sensation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/anal-sphincter-function","display_name":"anal sphincter function","score":0.8690000176429749},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.6729999780654907},{"id":"https://openalex.org/keywords/colorectal-inflammation","display_name":"colorectal inflammation","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2780101441","wikidata":"https://www.wikidata.org/wiki/Q949930","display_name":"Pouch","level":2,"score":0.9514301419258118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.906883955001831},{"id":"https://openalex.org/C2777077811","wikidata":"https://www.wikidata.org/wiki/Q7247499","display_name":"Proctocolectomy","level":4,"score":0.577155590057373},{"id":"https://openalex.org/C130093455","wikidata":"https://www.wikidata.org/wiki/Q173253","display_name":"Sensation","level":2,"score":0.5765731334686279},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.5234146118164062},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.4821721911430359},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.4638960361480713},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38776302337646484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.278991162776947},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000344","descriptor_name":"Afferent Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001003","descriptor_name":"Anal Canal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003187","descriptor_name":"Compliance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007082","descriptor_name":"Ileum","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008365","descriptor_name":"Manometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012007","descriptor_name":"Rectum","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012677","descriptor_name":"Sensation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016737","descriptor_name":"Proctocolectomy, Restorative","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8995947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8995947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"},{"id":"mag:2431363408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8995947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5134261427","display_name":"CONTRACTION COUPLING IN COLONIC MUSCLE","funder_award_id":"R01DK040919","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2170598004","https://openalex.org/W2037117551","https://openalex.org/W1574775092","https://openalex.org/W2012546797","https://openalex.org/W1973283322","https://openalex.org/W643518032","https://openalex.org/W2091183841","https://openalex.org/W2072108156","https://openalex.org/W2031612136","https://openalex.org/W2009805742"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,178,295],"afferent":[2,24],"innervation":[3],"of":[4,17,36,53,56,84,98,109,181,215,273,278,287,290,299,313],"ileoanal":[5,28,72,280,315],"pouches":[6,29],"plays":[7],"an":[8,62],"important":[9],"role":[10,269],"in":[11,14,27,114,143,185,192,247,256,270],"perception":[12,52],"and":[13,30,71,95,138,148,265,282],"reflex":[15,73],"regulation":[16],"pouch":[18,58,69,85,147,157,204,251,281,324],"function.":[19],"We":[20],"aimed":[21],"to":[22,90,207,212,254],"characterize":[23],"nerve":[25],"function":[26,74,246],"thereby":[31],"explain":[32,284],"the":[33,57,81,106,110,117,126,186,189,208,241,263,271,279,314,319],"clinical":[34,288],"presentation":[35],"patients":[37,44,144,154,201,248,291],"with":[38,116,145,155,202,218,240,249,292,318],"such":[39,219],"pouches.":[40],"METHODS:":[41],"In":[42,67],"eight":[43,194],"who":[45],"underwent":[46],"surgery":[47,111],"for":[48,136,163,297],"active":[49],"ulcerative":[50],"colitis,":[51],"balloon":[54],"distention":[55,65,198,277],"was":[59,183,228,238,252],"measured":[60],"using":[61],"electronic":[63],"visceral":[64],"device.":[66],"addition,":[68],"compliance":[70,227],"were":[75,78,141],"determined.":[76],"Studies":[77],"performed":[79],"during":[80,151,231,275],"initial":[82,179],"stage":[83,108],"creation":[86,312],"(pouch":[87],"without":[88],"connection":[89],"proximal":[91,242,320],"ileum,":[92],"study":[93,119,232],"1)":[94],"a":[96,146,156,159,203,220,250,268,285,293],"mean":[97],"6.6":[99],"wk":[100],"(range":[101],"=":[102,176],"2-12":[103],"wk)":[104],"after":[105,236],"second":[107],"(proximal":[112],"ileum":[113,264,321],"continuity":[115,237],"pouch,":[118],"2).":[120],"Nine":[121],"normal":[122],"volunteers":[123],"made":[124],"up":[125],"control":[127],"group.":[128],"RESULTS:":[129],"When":[130],"expressed":[131],"as":[132,210],"intrapouch":[133],"pressure,":[134],"thresholds":[135,296],"stool":[137,164],"discomfort":[139,182],"sensations":[140,206,274],"similar":[142,253],"controls.":[149,257],"However,":[150],"ramp":[152],"distention,":[153],"had":[158],"lower":[160],"volume":[161],"threshold":[162],"sensation":[165,180],"(143":[166],"+/-":[167,172],"45":[168],"ml":[169],"vs":[170],"300":[171],"30":[173],"ml,":[174],"p":[175],"0.009).":[177],"experienced":[184],"perineum":[187],"at":[188],"S3":[190],"dermatome":[191],"all":[193,200],"patients.":[195],"At":[196],"higher":[197],"pressures,":[199],"referred":[205],"abdomen,":[209],"opposed":[211],"only":[213],"one":[214],"nine":[216],"controls":[217],"referral":[221],"pattern":[222],"(p":[223],"<":[224],"0.0001).":[225],"Pouch":[226],"markedly":[229],"reduced":[230],"1":[233],"but":[234],"normalized":[235],"established":[239],"ileum.":[243],"Anal":[244],"sphincter":[245],"that":[255],"CONCLUSIONS:":[258],"Afferent":[259],"pathways":[260,301],"from":[261],"both":[262],"rectum":[266],"play":[267],"mediation":[272],"mechanical":[276],"can":[283],"number":[286],"features":[289],"pouch.":[294,316],"activation":[298],"these":[300],"are":[302],"not":[303],"significantly":[304,322],"altered":[305],"by":[306,311],"long-standing":[307],"colorectal":[308],"inflammation":[309],"or":[310],"Continuity":[317],"influences":[323],"compliance.":[325]},"counts_by_year":[{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}