{"id":"https://openalex.org/W2431070870","doi":null,"title":"[Potentiation of arsenic trioxide-induced apoptosis by retinoic acid in retinoic acid sensitive and resistant HL-60 myeloid leukemia cells].","display_name":"[Potentiation of arsenic trioxide-induced apoptosis by retinoic acid in retinoic acid sensitive and resistant HL-60 myeloid leukemia cells].","publication_year":2000,"publication_date":"2000-06-01","ids":{"openalex":"https://openalex.org/W2431070870","mag":"2431070870","pmid":"https://pubmed.ncbi.nlm.nih.gov/11775865"},"language":"zh","primary_location":{"id":"pmid:11775865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11775865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001999511","display_name":"Xiaojie Huang","orcid":"https://orcid.org/0000-0002-5045-9202","observed_orcids":["https://orcid.org/0000-0002-5045-9202","https://orcid.org/0000-0003-3441-7480"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"X Huang","raw_affiliation_strings":["Institute of Hematology, People's Hospital, Beijing Medical University, Beijing 100044, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology, People's Hospital, Beijing Medical University, Beijing 100044, China","institution_ids":["https://openalex.org/I4210124809"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001999511"],"corresponding_institution_ids":["https://openalex.org/I4210124809"],"apc_list":null,"apc_paid":null,"fwci":0.0995,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.40575964,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"113","issue":"6","first_page":"498","last_page":"501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":1.0},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9850000143051147},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/retinoic-acid-resistance","display_name":"retinoic acid resistance","score":0.8059999942779541},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.8450000286102295},{"id":"https://openalex.org/keywords/9-cis-retinoic-acid","display_name":"9-cis-retinoic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6970000267028809},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C2780386689","wikidata":"https://www.wikidata.org/wiki/Q7739","display_name":"Arsenic trioxide","level":3,"score":0.920505940914154},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.6866939067840576},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6668258905410767},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.544779896736145},{"id":"https://openalex.org/C2779963572","wikidata":"https://www.wikidata.org/wiki/Q29417","display_name":"Tretinoin","level":4,"score":0.5377101898193359},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5315278172492981},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.503879725933075},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.49959492683410645},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4938143193721771},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4919312000274658},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4851585030555725},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44563955068588257},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4378833770751953},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3739381432533264},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.359001100063324},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.283555805683136},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2499859631061554},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22115331888198853},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.2155986726284027},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077237","descriptor_name":"Arsenic Trioxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077556","descriptor_name":"Alitretinoin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001152","descriptor_name":"Arsenicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11775865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11775865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:2431070870","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11775865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2417384065","https://openalex.org/W2133935930","https://openalex.org/W2147200112","https://openalex.org/W2250583053","https://openalex.org/W2743201887","https://openalex.org/W2122465033","https://openalex.org/W7007271599","https://openalex.org/W2042425638","https://openalex.org/W2292904222","https://openalex.org/W1965948236"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2],"the":[3,17,154,177,191,207,213],"effect":[4,19],"of":[5,156,204],"arsenic":[6],"trioxide":[7],"(As2O3)":[8],"on":[9],"non-APL":[10,33,157,202],"acute":[11],"myeloid":[12],"leukemia":[13],"(AML)":[14],"cells":[15,35,134,159,174],"and":[16,24,29,45,54,75,87,95,109,123,125,132,206],"interreactive":[18],"between":[20],"retinoic":[21,106,111,192],"acid":[22,107,112,193],"(RA)":[23],"As2O3.":[25],"METHODS:":[26],"RA-sensitive":[27],"(S)":[28],"RA-resistant":[30,172],"(R)":[31],"HL-60":[32,173],"AML":[34,158,205],"were":[36,48],"used":[37,49],"as":[38,117],"an":[39],"in":[40,84,97,129,147,171,175,190,201],"vitro":[41],"model.":[42],"Cell":[43],"number":[44],"trypan":[46],"blue":[47],"to":[50,185],"observe":[51],"cell":[52,163],"growth":[53,155],"survival.":[55],"Apoptosis":[56],"was":[57,92],"determined":[58],"by":[59,119,160],"morphological":[60],"changes,":[61],"using":[62],"a":[63,76,98,186],"DNA":[64],"laddering":[65],"assay,":[66],"terminal":[67],"deoxynucleotidyl":[68],"transferase":[69],"(TdT)":[70],"fragment":[71,122],"end":[72],"labeling":[73,124],"assay":[74],"flow":[77,126],"cytometry":[78,127],"assay.":[79],"RESULTS:":[80],"As2O3":[81,100,142,145,151,196],"induced":[82],"apoptosis":[83,91,169],"both":[85,93,130,148],"HL-60S":[86,131],"HL-60R":[88,133],"cells,":[89],"As2O3-induced":[90,115,168],"time-":[94],"concentration-dependent":[96],"therapeutically-achievable":[99],"range":[101],"(0.25-4.0":[102],"mumol/L).":[103],"Both":[104],"all-trans":[105],"(ATRA)":[108],"9-cis":[110],"(9cRA)":[113],"potentiated":[114],"apoptosis,":[116],"measured":[118],"quantitative":[120],"TdT":[121],"assays":[128],"(P":[135],"<":[136],"0.05,":[137],"for":[138],"all":[139],"RA":[140,165],"+":[141],"combinations":[143],"vs":[144],"alone":[146],"sublines).":[149],"CONCLUSIONS:":[150],"may":[152],"inhibit":[153],"promoting":[161],"programmed":[162],"death.":[164],"can":[166,197],"potentiate":[167],"even":[170],"which":[176],"classical":[178],"ATRA":[179],"response":[180],"pathway":[181],"is":[182],"repressed":[183],"owing":[184],"homozygous":[187],"inactivating":[188],"mutation":[189],"receptor":[194],"alpha.":[195],"have":[198],"clinical":[199],"activity":[200,209],"cases":[203],"enhanced":[208],"might":[210],"result":[211],"from":[212],"combined":[214],"As2O3-RA":[215],"therapy.":[216]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}