{"id":"https://openalex.org/W2430748732","doi":"https://doi.org/10.1074/jbc.m115.705442","title":"The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the \u03b2-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2","display_name":"The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the \u03b2-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2","publication_year":2016,"publication_date":"2016-04-12","ids":{"openalex":"https://openalex.org/W2430748732","doi":"https://doi.org/10.1074/jbc.m115.705442","mag":"2430748732","pmid":"https://pubmed.ncbi.nlm.nih.gov/27068743","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4933447"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m115.705442","doi":"https://doi.org/10.1074/jbc.m115.705442","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.705442","pdf_url":"http://www.jbc.org/article/S0021925820409159/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820409159/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000966955","display_name":"Heather E. Croy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather E. Croy","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019791064","display_name":"Caitlyn N. Fuller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlyn N. Fuller","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076712313","display_name":"Jemma Giannotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jemma Giannotti","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031729136","display_name":"Paige Robinson","orcid":"https://orcid.org/0009-0009-4092-0489","observed_orcids":["https://orcid.org/0009-0009-4092-0489"]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paige Robinson","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057727078","display_name":"Andrew V.A. Foley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew V.A. Foley","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029497955","display_name":"Robert J. Yamulla","orcid":"https://orcid.org/0000-0002-0276-3592","observed_orcids":["https://orcid.org/0000-0002-0276-3592"]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Yamulla","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025422642","display_name":"Sean Cosgriff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Cosgriff","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078427997","display_name":"Bradford D. Greaves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradford D. Greaves","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011542569","display_name":"Ryan A. von Kleeck","orcid":"https://orcid.org/0000-0001-8085-5815","observed_orcids":["https://orcid.org/0000-0001-8085-5815"]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan A. von Kleeck","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015844165","display_name":"Hyun Hyung An","orcid":"https://orcid.org/0000-0002-7070-8552","observed_orcids":["https://orcid.org/0000-0002-7070-8552"]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyun Hyung An","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Catherine M. Powers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine M. Powers","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010713937","display_name":"Julie Tran","orcid":"https://orcid.org/0000-0001-6520-2832","observed_orcids":["https://orcid.org/0000-0001-6520-2832"]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie K. Tran","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080753932","display_name":"Aaron M. Tocker","orcid":"https://orcid.org/0000-0002-9672-0357","observed_orcids":["https://orcid.org/0000-0002-9672-0357"]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron M. Tocker","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008822197","display_name":"Kimberly D. Jacob","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly D. Jacob","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102970143","display_name":"Beckley K. Davis","orcid":"https://orcid.org/0000-0003-0673-8017","observed_orcids":["https://orcid.org/0000-0003-0673-8017"]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beckley K. Davis","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085029842","display_name":"David M. Roberts","orcid":"https://orcid.org/0000-0002-8019-9966","observed_orcids":["https://orcid.org/0000-0002-8019-9966"]},"institutions":[{"id":"https://openalex.org/I173146385","display_name":"Franklin & Marshall College","ror":"https://ror.org/04fp4ps48","country_code":"US","type":"education","lineage":["https://openalex.org/I173146385"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David M. Roberts","raw_affiliation_strings":["From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604. Electronic address: david.roberts@fandm.edu","From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604. Electronic address: david.roberts@fandm.edu","institution_ids":["https://openalex.org/I173146385"]},{"raw_affiliation_string":"From the Department of Biology, Franklin & Marshall College, Lancaster, Pennsylvania 17604","institution_ids":["https://openalex.org/I173146385"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085029842"],"corresponding_institution_ids":["https://openalex.org/I173146385"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.771,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.90457378,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"291","issue":"24","first_page":"12747","last_page":"12760"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tankyrase","display_name":"tankyrase","score":0.9599999785423279},{"id":"https://openalex.org/keywords/poly-adp-ribose-polymerase","display_name":"poly(ADP-ribose) polymerase","score":0.9649999737739563},{"id":"https://openalex.org/keywords/beta-catenin-destruction-complex","display_name":"\u03b2-catenin destruction complex","score":0.9760000109672546},{"id":"https://openalex.org/keywords/adp-ribosylation","display_name":"ADP-ribosylation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/axin","display_name":"Axin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/apc2","display_name":"APC2","score":0.9649999737739563},{"id":"https://openalex.org/keywords/adenomatous-polyposis-coli","display_name":"adenomatous polyposis coli","score":0.9259999990463257},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8999999761581421},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/ubiquitin-mediated-degradation","display_name":"ubiquitin-mediated proteolysis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6869999766349792},{"id":"https://openalex.org/keywords/tankyrase-inhibition","display_name":"tankyrase inhibition","score":0.5889999866485596},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.7705630660057068},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.6403585076332092},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5467884540557861},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46589672565460205},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46246498823165894},{"id":"https://openalex.org/C2776376580","wikidata":"https://www.wikidata.org/wiki/Q407355","display_name":"Transferase","level":3,"score":0.4286292493343353},{"id":"https://openalex.org/C45510557","wikidata":"https://www.wikidata.org/wiki/Q61420","display_name":"ADP-ribosylation","level":4,"score":0.41822487115859985},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37868615984916687},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30283790826797485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26616334915161133},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000246","descriptor_name":"Adenosine Diphosphate Ribose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038501","descriptor_name":"Tankyrases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D038501","descriptor_name":"Tankyrases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060466","descriptor_name":"Axin Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060466","descriptor_name":"Axin Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m115.705442","doi":"https://doi.org/10.1074/jbc.m115.705442","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.705442","pdf_url":"http://www.jbc.org/article/S0021925820409159/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4314642","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4933447","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4933447","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4933447","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:27068743","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27068743","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m115.705442","doi":"https://doi.org/10.1074/jbc.m115.705442","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.705442","pdf_url":"http://www.jbc.org/article/S0021925820409159/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1732240846","display_name":"A model system to study the tumor suppressor APC and its role in Wnt regulation.","funder_award_id":"R15GM107796","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6914090398","display_name":null,"funder_award_id":"52007538","funder_id":"https://openalex.org/F4320306082","funder_display_name":"Howard Hughes Medical Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320313688","display_name":"Franklin and Marshall College","ror":"https://ror.org/04fp4ps48"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2430748732.pdf","grobid_xml":"https://content.openalex.org/works/W2430748732.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1544046482","https://openalex.org/W1980788640","https://openalex.org/W1982313226","https://openalex.org/W1996984755","https://openalex.org/W1999460643","https://openalex.org/W1999982684","https://openalex.org/W2006155306","https://openalex.org/W2006419043","https://openalex.org/W2013708418","https://openalex.org/W2017511639","https://openalex.org/W2020634703","https://openalex.org/W2030556604","https://openalex.org/W2032578973","https://openalex.org/W2040942754","https://openalex.org/W2054366239","https://openalex.org/W2057257265","https://openalex.org/W2062452214","https://openalex.org/W2065585161","https://openalex.org/W2067446542","https://openalex.org/W2073992110","https://openalex.org/W2078564947","https://openalex.org/W2080214451","https://openalex.org/W2082120029","https://openalex.org/W2084705674","https://openalex.org/W2091118082","https://openalex.org/W2094398585","https://openalex.org/W2096171021","https://openalex.org/W2097132248","https://openalex.org/W2101889783","https://openalex.org/W2105240743","https://openalex.org/W2111927373","https://openalex.org/W2113105675","https://openalex.org/W2115001053","https://openalex.org/W2124008135","https://openalex.org/W2136137878","https://openalex.org/W2138528069","https://openalex.org/W2141505580","https://openalex.org/W2142506572","https://openalex.org/W2142518009","https://openalex.org/W2144311146","https://openalex.org/W2146167376","https://openalex.org/W2147573709","https://openalex.org/W2149598894","https://openalex.org/W2163716927","https://openalex.org/W2185657910","https://openalex.org/W2206475047","https://openalex.org/W4301326813"],"related_works":["https://openalex.org/W2144311146","https://openalex.org/W4416332405","https://openalex.org/W2478254560","https://openalex.org/W4414459965","https://openalex.org/W2082644873","https://openalex.org/W2605295245","https://openalex.org/W2289501098","https://openalex.org/W2741400969","https://openalex.org/W2142506572","https://openalex.org/W2147573709"],"abstract_inverted_index":{"Most":[0],"colon":[1,193],"cancer":[2,79,194,239],"cases":[3],"are":[4],"initiated":[5],"by":[6,61],"truncating":[7],"mutations":[8],"in":[9,30,106,119,128,192],"the":[10,24,37,50,65,145,150,154,220],"tumor":[11],"suppressor,":[12],"adenomatous":[13],"polyposis":[14],"coli":[15],"(APC).":[16],"APC":[17],"is":[18,76,126],"a":[19,31,77,83,92,115,235],"critical":[20],"negative":[21],"regulator":[22],"of":[23,64,96,222],"Wnt":[25,237],"signaling":[26],"pathway":[27,238],"that":[28,49,73,100,112,123,139,165,175,213],"participates":[29],"multi-protein":[32],"\"destruction":[33],"complex\"":[34],"to":[35,158],"target":[36],"key":[38],"effector":[39],"protein":[40,67,182],"\u03b2-catenin":[41,146,160,197],"for":[42,187],"ubiquitin-mediated":[43],"proteolysis.":[44,161],"Prior":[45],"work":[46,71],"has":[47],"established":[48],"poly(ADP-ribose)":[51],"polymerase":[52],"(PARP)":[53],"enzyme":[54],"Tankyrase":[55],"(TNKS)":[56],"antagonizes":[57],"destruction":[58,107,147,216],"complex":[59,108,217],"activity":[60,218],"promoting":[62],"degradation":[63],"scaffold":[66],"Axin,":[68],"and":[69,88,122,172,225],"recent":[70],"suggests":[72],"TNKS":[74,90,101,113,143,166,190,214,232],"inhibition":[75,191,233],"promising":[78],"therapy.":[80,240],"We":[81,110,162],"performed":[82],"yeast":[84],"two-hybrid":[85],"(Y2H)":[86],"screen":[87],"uncovered":[89],"as":[91,184,234],"putative":[93],"binding":[94],"partner":[95],"Drosophila":[97,120,170],"APC2,":[98,121,130,173,226],"suggesting":[99],"may":[102],"play":[103],"multiple":[104],"roles":[105],"regulation.":[109],"find":[111,138,201],"binds":[114],"C-terminal":[116],"RPQPSG":[117],"motif":[118,125],"this":[124],"conserved":[127],"human":[129,133],"but":[131,174],"not":[132,178],"APC1.":[134],"In":[135],"addition,":[136],"we":[137,200],"APC2":[140,181],"can":[141],"recruit":[142],"into":[144,231],"complex,":[148],"placing":[149],"APC2/TNKS":[151],"interaction":[152],"at":[153,219],"correct":[155],"intracellular":[156],"location":[157],"regulate":[159,180],"further":[163,228],"show":[164],"directly":[167],"PARylates":[168],"both":[169,223],"Axin":[171,207,224],"PARylation":[176],"does":[177,186],"globally":[179],"levels":[183],"it":[185],"Axin.":[188],"Moreover,":[189],"cells":[195],"decreases":[196],"signaling,":[198],"which":[199],"cannot":[202],"be":[203],"explained":[204],"solely":[205],"through":[206],"stabilization.":[208],"Instead,":[209],"our":[210],"findings":[211],"suggest":[212],"regulates":[215],"level":[221],"providing":[227],"mechanistic":[229],"insight":[230],"potential":[236]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}