{"id":"https://openalex.org/W2430700042","doi":null,"title":"[Effect of conjugated PRP vaccines on the incidence of invasive diseases caused by Haemophilus influenzae Type B in childhood].","display_name":"[Effect of conjugated PRP vaccines on the incidence of invasive diseases caused by Haemophilus influenzae Type B in childhood].","publication_year":1994,"publication_date":"1994-04-09","ids":{"openalex":"https://openalex.org/W2430700042","mag":"2430700042","pmid":"https://pubmed.ncbi.nlm.nih.gov/8184297"},"language":"de","primary_location":{"id":"pmid:8184297","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8184297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schweizerische medizinische Wochenschrift","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002012971","display_name":"Daniel Desgrandchamps","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119500","display_name":"Luzerner Kantonsspital","ror":"https://ror.org/02zk3am42","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210119500"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"D Desgrandchamps","raw_affiliation_strings":["P\u00e4diatrische Klinik, Kinderspital Luzern"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P\u00e4diatrische Klinik, Kinderspital Luzern","institution_ids":["https://openalex.org/I4210119500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034314982","display_name":"Roberto Kretschmer Schmid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Schmid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012621507","display_name":"Zimmermann Hp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H P Zimmermann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066014406","display_name":"P Imahorn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Imahorn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070959937","display_name":"K. Kabus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Kabus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"G Schubiger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Schubiger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4653,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.77108711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"124","issue":"14","first_page":"575","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haemophilus-influenzae-type-b","display_name":"Haemophilus influenzae type b","score":0.9800000190734863},{"id":"https://openalex.org/keywords/conjugate-vaccines","display_name":"conjugate vaccines","score":0.9240000247955322},{"id":"https://openalex.org/keywords/invasive-hib-disease","display_name":"invasive Hib disease","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hib-meningitis","display_name":"Hib meningitis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/epiglottitis","display_name":"epiglottitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/incidence-reduction","display_name":"incidence reduction","score":0.49399998784065247},{"id":"https://openalex.org/keywords/childhood-immunization","display_name":"childhood immunization","score":0.593999981880188},{"id":"https://openalex.org/keywords/vaccination-coverage","display_name":"vaccination coverage","score":0.6169999837875366},{"id":"https://openalex.org/keywords/case-fatality-rate","display_name":"case fatality rate","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9511358737945557},{"id":"https://openalex.org/C2777217862","wikidata":"https://www.wikidata.org/wiki/Q1347065","display_name":"Epiglottitis","level":2,"score":0.9278172254562378},{"id":"https://openalex.org/C2781026528","wikidata":"https://www.wikidata.org/wiki/Q48143","display_name":"Meningitis","level":2,"score":0.8029450178146362},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.7797414064407349},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.7647833824157715},{"id":"https://openalex.org/C187316915","wikidata":"https://www.wikidata.org/wiki/Q92307203","display_name":"Case fatality rate","level":3,"score":0.6177335381507874},{"id":"https://openalex.org/C2779583294","wikidata":"https://www.wikidata.org/wiki/Q5161160","display_name":"Conjugate vaccine","level":4,"score":0.5716496109962463},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5598365068435669},{"id":"https://openalex.org/C2776925733","wikidata":"https://www.wikidata.org/wiki/Q1141979","display_name":"Haemophilus influenzae","level":3,"score":0.4682510793209076},{"id":"https://openalex.org/C2779592421","wikidata":"https://www.wikidata.org/wiki/Q368134","display_name":"Hib vaccine","level":5,"score":0.4474329352378845},{"id":"https://openalex.org/C2776402342","wikidata":"https://www.wikidata.org/wiki/Q311275","display_name":"Haemophilus","level":3,"score":0.4316670298576355},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.21973785758018494},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21791866421699524},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.21221131086349487},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16614747047424316},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.09962880611419678},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.05910065770149231},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004168","descriptor_name":"Diphtheria Toxoid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004826","descriptor_name":"Epiglottitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D004826","descriptor_name":"Epiglottitis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006192","descriptor_name":"Haemophilus Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006192","descriptor_name":"Haemophilus Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008583","descriptor_name":"Meningitis, Haemophilus","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008583","descriptor_name":"Meningitis, Haemophilus","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013557","descriptor_name":"Switzerland","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018073","descriptor_name":"Haemophilus Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018074","descriptor_name":"Vaccines, Conjugate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8184297","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8184297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schweizerische medizinische Wochenschrift","raw_type":"Case Reports"},{"id":"mag:2430700042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8184297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1972308393","https://openalex.org/W1975935876","https://openalex.org/W1486694971","https://openalex.org/W2414184771","https://openalex.org/W2333584948","https://openalex.org/W1997577937","https://openalex.org/W4300946252","https://openalex.org/W2016457957","https://openalex.org/W2148663897","https://openalex.org/W2417332526"],"abstract_inverted_index":{"Prior":[0],"to":[1,31,47,103,112,144,248],"the":[2,13,41,62,66,76,136,238,243,251,261],"introduction":[3,126],"of":[4,16,44,51,75,93,116,127,138,149,160,165,180,183,188,194,206,211,231],"conjugate":[5],"vaccines,":[6],"Haemophilus":[7],"influenzae":[8],"type":[9],"b":[10],"(Hib)":[11],"was":[12,72,99,216,267],"leading":[14],"cause":[15],"severe":[17],"invasive":[18,139],"infections":[19],"in":[20,23,26,131,135,199,218,254],"young":[21],"children,":[22],"Switzerland":[24],"as":[25],"other":[27],"countries.":[28],"From":[29,101,142],"1976":[30],"1990,":[32,104],"150":[33],"children":[34,56,81,98,106,121,170,202,234],"were":[35,107,153,167],"treated":[36],"for":[37,70,109,250],"Hib":[38,140],"meningitis":[39,71,77,150,161,184,196],"at":[40],"Children's":[42],"Hospital":[43],"Lucerne,":[45],"corresponding":[46,111],"an":[48,90,113],"annual":[49,91,114,178],"incidence":[50,92,115],"9.2":[52],"cases":[53,78,95,118,147,164,176,182,187,197],"per":[54,96,119,190],"100,000":[55,97,120,191],"aged":[57,82,122],"under":[58,83,123,171,203,235],"15":[59,172],"years.":[60,85],"In":[61,155],"same":[63],"time":[64],"period,":[65],"case":[67,159,215],"fatality":[68],"rate":[69],"4%.":[73],"87.3%":[74],"occurred":[79,198],"among":[80,233],"5":[84,236],"For":[86,169],"this":[87,255,265],"age":[88,207,258],"group":[89,259],"26.4":[94],"calculated.":[100],"1979":[102],"141":[105],"hospitalized":[108],"epiglottitis,":[110],"10.9":[117],"15.":[124],"The":[125],"conjugated":[128],"vaccines":[129],"resulted":[130],"a":[132,219,228],"significant":[133],"reduction":[134],"frequency":[137],"disease.":[141],"1991":[143,240],"1992,":[145,242],"9":[146],"each":[148],"and":[151,162,185,213,241],"epiglottitis":[152,166,189],"observed.":[154],"1993,":[156],"only":[157,224,264],"one":[158,225],"2":[163,193,204],"seen.":[168],"years":[173,205,239],"these":[174],"21":[175],"represent":[177],"incidences":[179],"3.2":[181],"3.6":[186],"children.":[192],"10":[195],"twice":[200],"vaccinated":[201,222],"with":[208,223],"no":[209],"signs":[210],"immunodeficiency,":[212],"another":[214],"seen":[217],"5-month-old":[220],"infant":[221],"dose.":[226],"Assuming":[227],"vaccination":[229],"coverage":[230],"70%":[232],"during":[237,260],"calculated":[244],"efficacy":[245],"is":[246],"80":[247],"85%":[249],"vaccine":[252,266],"PRP-D":[253],"predominantly":[256],"affected":[257],"period":[262],"when":[263],"available.(ABSTRACT":[268],"TRUNCATED":[269],"AT":[270],"250":[271],"WORDS)":[272]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}