{"id":"https://openalex.org/W2429629127","doi":null,"title":"Evidence for two mechanisms of flocculation in Saccharomyces cerevisiae.","display_name":"Evidence for two mechanisms of flocculation in Saccharomyces cerevisiae.","publication_year":1989,"publication_date":"1989-04-01","ids":{"openalex":"https://openalex.org/W2429629127","mag":"2429629127","pmid":"https://pubmed.ncbi.nlm.nih.gov/2665372"},"language":"en","primary_location":{"id":"pmid:2665372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2665372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yeast (Chichester, England)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019204180","display_name":"Malcolm Stratford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018370718","display_name":"Quadram Institute","ror":"https://ror.org/04td3ys19","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799693246","https://openalex.org/I3018370718","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"M Stratford","raw_affiliation_strings":["AFRC, Institute of Food Research, Norwich Laboratory, England"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AFRC, Institute of Food Research, Norwich Laboratory, England","institution_ids":["https://openalex.org/I3018370718"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019204180"],"corresponding_institution_ids":["https://openalex.org/I3018370718"],"apc_list":null,"apc_paid":null,"fwci":0.7546,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.66604036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5 Spec No","issue":null,"first_page":"S441","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flocculation","display_name":"flocculation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sugar-inhibition","display_name":"sugar inhibition","score":0.6029999852180481},{"id":"https://openalex.org/keywords/mannose","display_name":"mannose","score":0.8100000023841858},{"id":"https://openalex.org/keywords/tup1","display_name":"Tup1","score":0.7730000019073486},{"id":"https://openalex.org/keywords/mannose-specific-lectin","display_name":"mannose-specific lectin","score":0.7789999842643738},{"id":"https://openalex.org/keywords/chaotropic-effect","display_name":"chaotropic effect","score":0.6489999890327454},{"id":"https://openalex.org/keywords/ammonium-repression","display_name":"ammonium repression","score":0.921999990940094},{"id":"https://openalex.org/keywords/flocculation-mechanism","display_name":"flocculation mechanism","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2778197599","wikidata":"https://www.wikidata.org/wiki/Q170002","display_name":"Maltose","level":3,"score":0.7992570400238037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7657718062400818},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.7559763193130493},{"id":"https://openalex.org/C148815931","wikidata":"https://www.wikidata.org/wiki/Q900689","display_name":"Flocculation","level":2,"score":0.7228302955627441},{"id":"https://openalex.org/C2775887612","wikidata":"https://www.wikidata.org/wiki/Q10809118","display_name":"Mannose","level":2,"score":0.7033984661102295},{"id":"https://openalex.org/C2777108408","wikidata":"https://www.wikidata.org/wiki/Q11002","display_name":"Sugar","level":2,"score":0.5615019798278809},{"id":"https://openalex.org/C2779870022","wikidata":"https://www.wikidata.org/wiki/Q190901","display_name":"Ammonium","level":2,"score":0.5549238920211792},{"id":"https://openalex.org/C2778597767","wikidata":"https://www.wikidata.org/wiki/Q4027534","display_name":"Sucrose","level":2,"score":0.5148996114730835},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.507476270198822},{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.506683886051178},{"id":"https://openalex.org/C2778173381","wikidata":"https://www.wikidata.org/wiki/Q66589593","display_name":"Galactose","level":2,"score":0.43581992387771606},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.42547979950904846},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.34752845764160156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14757603406906128},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05682772397994995}],"mesh":[{"descriptor_ui":"D002122","descriptor_name":"Calcium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005427","descriptor_name":"Flocculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012965","descriptor_name":"Sodium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2665372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2665372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yeast (Chichester, England)","raw_type":"Journal Article"},{"id":"mag:2429629127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2665372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1985158887","https://openalex.org/W2048978195","https://openalex.org/W2054749072","https://openalex.org/W7131638123","https://openalex.org/W1995407969","https://openalex.org/W2158343599","https://openalex.org/W1919432888","https://openalex.org/W2601434309","https://openalex.org/W2013576975","https://openalex.org/W2196413373"],"abstract_inverted_index":{"Inhibition":[0],"of":[1,10,108,122],"flocculation":[2,96],"by":[3,39,49,62,72,105],"sugars":[4],"was":[5],"studied":[6],"in":[7,86,129,139],"41":[8],"strains":[9,23,66,92,101],"Saccharomyces":[11],"cerevisiae.":[12],"Two":[13],"distinct":[14,120],"groupings":[15],"were":[16,36,46,57,60,67],"found.":[17],"The":[18,42],"first":[19],"type,":[20],"including":[21],"all":[22],"containing":[24],"FLO":[25,27,29,31,77,89,131],"1,":[26,35],"4,":[28],"5,":[30],"8":[32],"and":[33,53,59,134],"TUP":[34],"partially":[37],"inhibited":[38,48],"mannose":[40],"only.":[41],"second":[43],"type":[44,79,91,133],"(NewFLO)":[45],"completely":[47,103],"mannose,":[50],"maltose,":[51],"glucose":[52],"sucrose.":[54],"Sugar":[55],"inhibitions":[56],"reversible":[58],"exacerbated":[61],"increased":[63],"agitation.":[64],"NewFLO":[65,100,141],"more":[68],"sensitive":[69],"to":[70],"inhibition":[71,82],"inorganic":[73],"salts":[74],"than":[75],"the":[76,106,130,140],"1":[78,90,132],"strains.":[80],"This":[81],"is":[83,113],"probably":[84,124],"chaotropic":[85],"nature.":[87],"Most":[88],"are":[93,102],"constitutive,":[94],"expressing":[95],"throughout":[97],"growth,":[98],"whereas,":[99],"repressed":[104],"presence":[107],"excess":[109],"ammonium":[110],"ions.":[111],"It":[112],"proposed":[114],"that":[115],"this":[116],"indicates":[117],"two":[118],"entirely":[119],"mechanisms":[121],"flocculation,":[123],"involving":[125],"a":[126,135],"mannose-specific":[127],"lectin":[128,138],"broad":[136],"specificity":[137],"type.":[142]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}