{"id":"https://openalex.org/W2428709686","doi":null,"title":"Restoration of the thymic cellular microenvironment following autologous bone marrow transplantation.","display_name":"Restoration of the thymic cellular microenvironment following autologous bone marrow transplantation.","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W2428709686","mag":"2428709686","pmid":"https://pubmed.ncbi.nlm.nih.gov/12073772"},"language":"en","primary_location":{"id":"pmid:12073772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12073772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052277840","display_name":"B B\u00f6dey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bela Bodey","raw_affiliation_strings":["Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Bodey18@aol.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Bodey18@aol.com","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028334828","display_name":"Stuart E. Siegel","orcid":"https://orcid.org/0000-0002-4305-1874","observed_orcids":["https://orcid.org/0000-0002-4305-1874"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stuart E Siegel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111393371","display_name":"Hans Elmar Kaiser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans E Kaiser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1094,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.50265909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"16","issue":"2","first_page":"127","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.18950000405311584,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymic-involution","display_name":"thymic involution","score":0.8619999885559082},{"id":"https://openalex.org/keywords/autologous-bone-marrow-transplantation","display_name":"autologous bone marrow transplantation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/thymus-regeneration","display_name":"thymus regeneration","score":0.7269999980926514},{"id":"https://openalex.org/keywords/hassall-s-bodies","display_name":"Hassall's bodies","score":0.8199999928474426},{"id":"https://openalex.org/keywords/thymic-hormones","display_name":"thymic hormones","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C2777314012","wikidata":"https://www.wikidata.org/wiki/Q7799617","display_name":"Thymic involution","level":4,"score":0.7624015808105469},{"id":"https://openalex.org/C2781409172","wikidata":"https://www.wikidata.org/wiki/Q17056802","display_name":"Involution (esoterism)","level":3,"score":0.737663984298706},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5085030794143677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4793163537979126},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.46950292587280273},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.464387983083725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45525750517845154},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45108562707901},{"id":"https://openalex.org/C2779615886","wikidata":"https://www.wikidata.org/wiki/Q3090790","display_name":"Thymectomy","level":3,"score":0.4232238233089447},{"id":"https://openalex.org/C2779159893","wikidata":"https://www.wikidata.org/wiki/Q1429863","display_name":"Thymoma","level":2,"score":0.41946983337402344},{"id":"https://openalex.org/C79904392","wikidata":"https://www.wikidata.org/wiki/Q5976738","display_name":"Lymphopoiesis","level":4,"score":0.4165574312210083},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.39022529125213623},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3508593738079071},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.35068756341934204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3190080523490906},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.318015456199646},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15822309255599976},{"id":"https://openalex.org/C186720457","wikidata":"https://www.wikidata.org/wiki/Q7087","display_name":"Consciousness","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C2778105408","wikidata":"https://www.wikidata.org/wiki/Q8285","display_name":"Myasthenia gravis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12073772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12073772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Journal Article"},{"id":"mag:2428709686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12073772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1885968133","https://openalex.org/W3119829124","https://openalex.org/W1683467081","https://openalex.org/W2018311782","https://openalex.org/W4297338478","https://openalex.org/W2396350103","https://openalex.org/W2285358510","https://openalex.org/W2051607166","https://openalex.org/W4211085940","https://openalex.org/W4385687401"],"abstract_inverted_index":{"Mammalian":[0],"thymic":[1,33,123,196,202,207],"histogenesis":[2],"can":[3,172,191],"be":[4,173,192],"morphologically":[5],"divided":[6],"into":[7],"three":[8],"consecutive":[9],"stages:":[10],"1)":[11],"epithelial;":[12],"2)":[13],"lymphopoietic":[14],"or":[15,199],"lympho-epithelial;":[16],"and":[17,42,48,58,83,90,102,131,139,187,210,230,259,268],"3)":[18],"differentiated":[19],"cellular":[20,34],"microenvironmental,":[21],"with":[22,167],"formation":[23],"of":[24,31,54,69,81,93,99,114,118,148,201,223,244,271,274],"Hassall's":[25],"bodies":[26],"(HBs).":[27],"The":[28,116,204,219],"marked":[29,136],"reduction":[30],"the":[32,52,55,60,66,88,122,154,157,168,216,242,272,275],"microenvironment":[35],"(TCM)":[36],"is":[37,43,156,212],"a":[38,178,234],"well-controlled":[39],"physiological":[40],"process":[41],"presumably":[44],"under":[45],"both":[46],"local":[47],"global":[49],"regulation":[50],"by":[51,59,195],"cells":[53],"RE":[56],"meshwork":[57],"neuroendocrine":[61],"axis,":[62],"respectively.":[63],"In":[64,95],"humans,":[65],"age-related":[67,165],"decline":[68,106,179],"facteur":[70],"thymique":[71],"s\u00e9rique":[72],"(FTS)":[73],"levels":[74,98],"in":[75,135,180,252,263,266],"blood":[76],"begins":[77],"after":[78,227],"20":[79],"years":[80,113],"age":[82],"FTS":[84],"completely":[85],"disappears":[86],"between":[87],"5th":[89],"6th":[91],"decade":[92],"life.":[94],"contrast,":[96],"serum":[97],"thymosin-alpha":[100],"1":[101],"thymopoietin":[103],"seem":[104],"to":[105,144],"earlier,":[107],"starting":[108],"as":[109,111,277,279],"early":[110],"10":[112],"age.":[115],"influences":[117],"other":[119],"hormones":[120],"on":[121],"involution":[124,166,186],"have":[125],"also":[126],"been":[127],"characterized:":[128],"testosterone,":[129],"estrogen":[130],"hydrocortisone":[132],"treatment":[133,261],"results":[134],"involution,":[137],"cortisone":[138],"progesterone":[140],"administration":[141,200],"causes":[142],"slight":[143],"moderate,":[145],"while":[146],"use":[147],"desoxycorticosterone":[149],"has":[150],"no":[151],"effect.":[152],"Since":[153],"thymus":[155],"primary":[158],"T-lymphopoietic":[159],"organ":[160,217],"during":[161],"mammalian":[162],"ontogenesis,":[163],"its":[164],"typical":[169],"immunomorphological":[170],"alterations":[171],"held":[174],"responsible":[175],"only":[176,220,251],"for":[177,206],"antigen-specific":[181],"T-lymphocyte":[182,189,247],"immune":[183],"functions.":[184],"Thymic":[185],"diminished":[188],"proliferation":[190,209],"partially":[193],"restored":[194],"tissue":[197],"transplantation":[198],"hormones.":[203],"stimulus":[205],"cell":[208,257],"differentiation":[211],"genetically":[213],"determined":[214],"within":[215],"implant.":[218],"partial":[221],"reconstitution":[222],"CD4+":[224,246],"T-helper-lymphocyte":[225],"subset":[226],"anti-neoplastic":[228],"chemotherapy":[229],"autologous":[231],"BTM":[232],"represents":[233],"significant,":[235],"therapy-complicating,":[236],"clinical":[237],"problem.":[238],"After":[239],"high-dose":[240],"chemotherapy,":[241],"restoration":[243],"thymus-dependent":[245],"genesis":[248],"was":[249],"reported":[250],"children.":[253],"Our":[254],"radiation,":[255],"stem":[256],"transplantation,":[258],"hormone":[260],"experiments":[262],"animals":[264],"resulted":[265],"age-":[267],"time-dependent":[269],"regeneration":[270],"cytoarchitecture":[273],"TCM,":[276],"well":[278],"intrathymic":[280],"lymphopoiesis.":[281]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}