{"id":"https://openalex.org/W2428526210","doi":null,"title":"Mitochondrial DNA influences radiation sensitivity and induction of apoptosis in human fibroblasts.","display_name":"Mitochondrial DNA influences radiation sensitivity and induction of apoptosis in human fibroblasts.","publication_year":1999,"publication_date":"1999-11-01","ids":{"openalex":"https://openalex.org/W2428526210","mag":"2428526210","pmid":"https://pubmed.ncbi.nlm.nih.gov/10697496"},"language":"en","primary_location":{"id":"pmid:10697496","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10697496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108599851","display_name":"Tang Jt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J T Tang","raw_affiliation_strings":["Department of Radiation Oncology, Osaka University Medical School, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Osaka University Medical School, Japan","institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005303054","display_name":"Hideya Yamazaki","orcid":"https://orcid.org/0000-0001-7508-7217","observed_orcids":["https://orcid.org/0000-0001-7508-7217"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Yamazaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087333755","display_name":"Takafumi Inoue","orcid":"https://orcid.org/0000-0002-2728-0060","observed_orcids":["https://orcid.org/0000-0002-2728-0060","https://orcid.org/0009-0000-8527-5844"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Inoue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102844033","display_name":"Masahiko Koizumi","orcid":"https://orcid.org/0000-0003-3438-9811","observed_orcids":["https://orcid.org/0000-0003-3438-9811"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Koizumi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083076498","display_name":"Kenji Yoshida","orcid":"https://orcid.org/0000-0003-4755-5807","observed_orcids":["https://orcid.org/0000-0003-4755-5807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Yoshida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112389360","display_name":"Shuji Ozeki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Ozeki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"T Inoue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Inoue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1876,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.79314142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"19","issue":"6B","first_page":"4959","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.6035000085830688,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.3418000042438507,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.04019999876618385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":1.0},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/human-fibroblasts","display_name":"human fibroblasts","score":0.9810000061988831},{"id":"https://openalex.org/keywords/rho0-cells","display_name":"rho0 cells","score":0.7160000205039978},{"id":"https://openalex.org/keywords/cell-survival","display_name":"cell survival","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cell-cycle-distribution","display_name":"cell cycle distribution","score":0.7009999752044678},{"id":"https://openalex.org/keywords/colony-formation","display_name":"colony formation","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7995645999908447},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.6848104000091553},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6831053495407104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6351603269577026},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6344964504241943},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6248060464859009},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.6232255101203918},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5993882417678833},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.586506187915802},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5567050576210022},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5536429286003113},{"id":"https://openalex.org/C26114605","wikidata":"https://www.wikidata.org/wiki/Q7280368","display_name":"Radiation sensitivity","level":3,"score":0.42298823595046997},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41955065727233887},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16386249661445618},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.15119782090187073},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04904162883758545},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10697496","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10697496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2428526210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10697496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2361676139","https://openalex.org/W2127416322","https://openalex.org/W42200090","https://openalex.org/W7145030272","https://openalex.org/W2485678552","https://openalex.org/W1964351700","https://openalex.org/W2355343429","https://openalex.org/W2999748631","https://openalex.org/W2108553329","https://openalex.org/W2349760173"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1,17],"aimed":[2],"to":[3,74],"assess":[4],"the":[5,77,85,90,94,104,123,140],"role":[6,151],"of":[7,157],"mitochondrial":[8],"DNA":[9],"(mtDNA)":[10],"in":[11,139,152],"ionizing":[12],"irradiation.":[13,112],"MATERIAL":[14],"AND":[15],"METHODS:":[16],"examined":[18],"three":[19],"human":[20],"fibroblast":[21],"cell":[22,68,80,101,105,126,141],"lines":[23,81,106,127],"either":[24],"lacking":[25],"mtDNA":[26,32,37,147],"(rho":[27,38],"0":[28,67,96,115],"cell),":[29],"carrying":[30],"mutant":[31],"(syn":[33],"cell)":[34],"or":[35],"normal":[36],"+":[39],"cell).":[40],"Cell":[41,53],"survival":[42],"curves":[43],"were":[44,59],"generated":[45],"with":[46],"colony":[47,86],"formation":[48,87],"and":[49,56,109,131,135,155],"dye":[50,91],"exclusion":[51,92],"tests.":[52],"cycle":[54,142],"analysis":[55],"apoptosis":[57,118],"assay":[58],"performed":[60],"by":[61,84],"flow":[62],"cytometry.":[63],"RESULTS:":[64],"The":[65,113],"rho":[66,95,114],"line":[69],"showed":[70,136],"a":[71,99],"stronger":[72],"resistance":[73],"irradiation":[75],"than":[76,122],"other":[78,124],"two":[79,125],"when":[82],"assessed":[83],"assay.":[88],"In":[89],"test,":[93],"cells":[97,116],"revealed":[98],"superior":[100],"viability":[102],"among":[103,144],"after":[107,128],"5":[108,130],"8":[110,132],"Gy":[111,133],"underwent":[117],"at":[119],"lower":[120],"rates":[121],"2,":[129],"irradiation,":[134],"no":[137],"alterations":[138],"distribution":[143],"them.":[145],"CONCLUSION:":[146],"plays":[148],"an":[149],"important":[150],"radiation":[153],"sensitivity":[154],"induction":[156],"apoptosis.":[158]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
