{"id":"https://openalex.org/W2428512706","doi":null,"title":"Frequent apoptosis in human kidneys after acute renal hypoperfusion.","display_name":"Frequent apoptosis in human kidneys after acute renal hypoperfusion.","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W2428512706","mag":"2428512706","pmid":"https://pubmed.ncbi.nlm.nih.gov/9386976"},"language":"en","primary_location":{"id":"pmid:9386976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9386976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental nephrology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089751113","display_name":"Ronen Jaffe","orcid":"https://orcid.org/0000-0002-6875-7427","observed_orcids":["https://orcid.org/0000-0002-6875-7427"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"R Jaffe","raw_affiliation_strings":["Department of Medicine, Hadassah University Hospital-Mt. Scopus, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Hadassah University Hospital-Mt. Scopus, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":null,"display_name":"I Ariel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Ariel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020092566","display_name":"R\u043enen Beeri","orcid":"https://orcid.org/0000-0002-8014-0702","observed_orcids":["https://orcid.org/0000-0002-8014-0702"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Beeri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023542498","display_name":"Ora Paltiel","orcid":"https://orcid.org/0000-0001-8324-3873","observed_orcids":["https://orcid.org/0000-0001-8324-3873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Paltiel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040600701","display_name":"Yehuda Hiss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Hiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065292902","display_name":"Seymour Rosen","orcid":"https://orcid.org/0000-0002-0832-5139","observed_orcids":["https://orcid.org/0000-0002-0832-5139"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Rosen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052051639","display_name":"Mayer Brezis","orcid":"https://orcid.org/0000-0002-3199-9641","observed_orcids":["https://orcid.org/0000-0002-3199-9641"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Brezis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6541,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.81802233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"5","issue":"5","first_page":"399","last_page":"403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/renal-tubular-epithelial-cells","display_name":"renal tubular epithelial cells","score":0.8230000138282776},{"id":"https://openalex.org/keywords/acute-tubular-necrosis","display_name":"acute tubular necrosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/renal-hypoxia","display_name":"renal hypoxia","score":0.8539999723434448},{"id":"https://openalex.org/keywords/acute-renal-dysfunction","display_name":"acute renal dysfunction","score":0.546999990940094},{"id":"https://openalex.org/keywords/sudden-death","display_name":"sudden death","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.8876461982727051},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7933940887451172},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.742188036441803},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.6419336795806885},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6231977343559265},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5848388075828552},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.5696226358413696},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.553420901298523},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5508367419242859},{"id":"https://openalex.org/C2777350860","wikidata":"https://www.wikidata.org/wiki/Q2425407","display_name":"Acute tubular necrosis","level":3,"score":0.4944148063659668},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.49201270937919617},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47469180822372437},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.4250355362892151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4034273028373718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29309043288230896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16649851202964783},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004396","descriptor_name":"Coloring Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007683","descriptor_name":"Kidney Tubular Necrosis, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9386976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9386976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental nephrology","raw_type":"Journal Article"},{"id":"mag:2428512706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9386976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2019845353","https://openalex.org/W2262348766","https://openalex.org/W63098812","https://openalex.org/W2380143342","https://openalex.org/W2076369548","https://openalex.org/W2416538636","https://openalex.org/W2163615971","https://openalex.org/W2056646930","https://openalex.org/W2378692875","https://openalex.org/W2235325702"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Apoptosis,":[1],"a":[2],"form":[3],"of":[4,23,44,87,94,110,146],"cell":[5],"death":[6],"characterized":[7],"by":[8,16,62,105],"DNA":[9,58,76,121,126],"fragmentation":[10,59,77,122,127],"and":[11,50,70,113,133],"minimal":[12],"inflammation,":[13],"is":[14],"induced":[15],"intrarenal":[17],"hypoxia":[18],"in":[19,32,63,84,92,108,142],"rats.":[20],"The":[21],"objective":[22],"this":[24],"study":[25,89],"was":[26,60,82,103],"to":[27,72,149],"test":[28],"whether":[29],"apoptosis":[30],"participates":[31],"human":[33],"acute":[34,117],"renal":[35,79,118,131,137],"injury.":[36],"METHODS:":[37],"We":[38],"examined":[39],"kidneys":[40],"obtained":[41],"from":[42,51],"autopsies":[43],"40":[45],"patients":[46,90,112],"following":[47,54],"hemodynamic":[48],"compromise":[49],"9":[52],"controls":[53,96],"sudden":[55],"death.":[56],"Nuclear":[57],"assayed":[61],"situ":[64],"3'":[65],"end":[66],"labeling":[67],"(TUNEL":[68],"stain)":[69],"compared":[71],"histological":[73],"findings.":[74],"RESULTS:":[75],"along":[78],"tubular":[80,101],"cells":[81],"observed":[83],"23":[85],"(57%)":[86],"the":[88,95,111,143,147],"but":[91],"none":[93],"(p":[97],"<":[98],"0.005).":[99],"Acute":[100],"necrosis":[102],"seen":[104],"formal":[106],"histology":[107],"27%":[109],"correlated":[114],"with":[115],"clinical":[116],"dysfunction,":[119],"while":[120],"did":[123],"not.":[124],"CONCLUSION:":[125],"often":[128],"occurs":[129],"after":[130],"hypoperfusion":[132],"does":[134],"not":[135],"imply":[136],"failure.":[138],"Apoptosis":[139],"may":[140],"participate":[141],"adaptive":[144],"response":[145],"kidney":[148],"hypoxia.":[150]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}