{"id":"https://openalex.org/W2426532154","doi":"https://doi.org/10.1093/ajcp/140.suppl1.065","title":"Molecular Profiling by Next-Generation Sequencing in Nonsmall Cell Lung Cancer","display_name":"Molecular Profiling by Next-Generation Sequencing in Nonsmall Cell Lung Cancer","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W2426532154","doi":"https://doi.org/10.1093/ajcp/140.suppl1.065","mag":"2426532154"},"language":"en","primary_location":{"id":"doi:10.1093/ajcp/140.suppl1.065","doi":"https://doi.org/10.1093/ajcp/140.suppl1.065","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajcp/140.suppl1.065","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079177940","display_name":"Weiqiang Zhao","orcid":"https://orcid.org/0000-0001-6560-2780","observed_orcids":["https://orcid.org/0000-0001-6560-2780"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiqiang Zhao","raw_affiliation_strings":["Ohio State University Medical Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State University Medical Center, Columbus, OH","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080967462","display_name":"Susan Long","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Long","raw_affiliation_strings":["Wexner Medical Center at OSU, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wexner Medical Center at OSU, Columbus, OH","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Greg Burton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg Burton","raw_affiliation_strings":["Wexner Medical Center at OSU, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wexner Medical Center at OSU, Columbus, OH","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057985193","display_name":"Kara Patterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kara Patterson","raw_affiliation_strings":["Wexner Medical Center at OSU, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wexner Medical Center at OSU, Columbus, OH","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049984514","display_name":"Nehad Mohamed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nehad Mohamed","raw_affiliation_strings":["Wexner Medical Center at OSU, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wexner Medical Center at OSU, Columbus, OH","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032878146","display_name":"Miguel A. Villalona","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miguel Villalona","raw_affiliation_strings":["Wexner Medical Center at OSU, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wexner Medical Center at OSU, Columbus, OH","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004712121","display_name":"Gregory A. Otterson","orcid":"https://orcid.org/0000-0001-9877-8512","observed_orcids":["https://orcid.org/0000-0001-9877-8512"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Otterson","raw_affiliation_strings":["Wexner Medical Center at OSU, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wexner Medical Center at OSU, Columbus, OH","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088856020","display_name":"Sameek Roychowdhury","orcid":"https://orcid.org/0000-0002-8297-3038","observed_orcids":["https://orcid.org/0000-0002-8297-3038"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sameek Roychowdhury","raw_affiliation_strings":["Wexner Medical Center at OSU, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wexner Medical Center at OSU, Columbus, OH","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051548428","display_name":"Konstantin Shilo","orcid":"https://orcid.org/0000-0002-6702-3130","observed_orcids":["https://orcid.org/0000-0002-6702-3130"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Konstantin Shilo","raw_affiliation_strings":["Ohio State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State University","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089790828","display_name":"Amy S. Gewirtz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy Gewirtz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4660,"currency":"USD","value_usd":4660},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"140","issue":"suppl 1","first_page":"A065","last_page":"A065"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.08169999718666077,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9779999852180481},{"id":"https://openalex.org/keywords/next-generation-sequencing","display_name":"next-generation sequencing","score":0.8420000076293945},{"id":"https://openalex.org/keywords/molecular-profiling","display_name":"molecular profiling","score":0.7990000247955322},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.7059999704360962},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":1.0},{"id":"https://openalex.org/keywords/formalin-fixed-paraffin-embedded-tissue","display_name":"formalin-fixed paraffin-embedded tissue","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.46399998664855957},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.921999990940094},{"id":"https://openalex.org/keywords/mutation-detection-sensitivity","display_name":"mutation detection sensitivity","score":0.6050000190734863},{"id":"https://openalex.org/keywords/ion-torrent-pgm","display_name":"Ion Torrent PGM","score":0.45100000500679016}],"concepts":[{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.7104639410972595},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5616106986999512},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.5603445172309875},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.5581903457641602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4419528841972351},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.42900437116622925},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41242730617523193},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3668515384197235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36443135142326355},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2955034375190735},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23762741684913635},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.21101832389831543},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14604178071022034},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11931183934211731},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ajcp/140.suppl1.065","doi":"https://doi.org/10.1093/ajcp/140.suppl1.065","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajcp/140.suppl1.065","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2890430067","https://openalex.org/W2765127052","https://openalex.org/W2993793127","https://openalex.org/W2809437512","https://openalex.org/W2990919719","https://openalex.org/W4379345291","https://openalex.org/W2070396662","https://openalex.org/W2562492902","https://openalex.org/W2615391251","https://openalex.org/W4411869996"],"abstract_inverted_index":{"Recent":[0],"technology":[1],"advances":[2],"in":[3,158,177,249,255,290],"multiplex":[4],"genotyping":[5],"and":[6,21,61,87,104,113,123,147,156,224,230,238,262,278],"high-throughput":[7],"genomic":[8,99],"profiling":[9,289],"by":[10,91,135,241],"next-generation":[11],"sequencing":[12,115,223],"(NGS)":[13],"technologies":[14],"now":[15],"offer":[16],"the":[17,24,39,114,136,167,183],"possibility":[18],"of":[19,27,185],"rapidly":[20],"comprehensively":[22],"interrogating":[23],"cancer":[25],"genome":[26],"individual":[28],"patients":[29,54],"from":[30,51,82,195,215,236],"small":[31],"tumor":[32,49],"biopsies":[33],"but":[34,174,252,283],"sufficient":[35],"data":[36],"to":[37,106,163,197],"support":[38],"clinical":[40,280],"utilization":[41],"are":[42],"limited.":[43],"Surgically":[44],"resected":[45],"formalin-fixed":[46],"paraffin-embedded":[47],"(FFPE)":[48],"tissues":[50],"26":[52],"consecutive":[53],"with":[55,57],"NSCLC":[56,291],"known":[58],"EGFR,":[59],"KRAS,":[60],"BRAF":[62],"mutations":[63,152,233,246,254],"were":[64,72,89,111,117,133,153,234,247,264],"identified":[65],"retrospectively.":[66],"Six":[67],"available":[68],"cancer/leukemia":[69],"cell":[70,202],"lines":[71,203],"characterized":[73],"for":[74,142,188,227,287],"potential":[75],"use":[76],"as":[77],"controls.":[78],"DNA":[79,100,214],"was":[80,101,193],"extracted":[81],"FFPE":[83,216,239],"or":[84,210],"cultured":[85],"cells":[86],"qualities/quantities":[88],"assessed":[90],"Qubit":[92],"dsDNA":[93],"HS":[94],"Assay":[95],"Kit.":[96],"10":[97],"ng":[98],"fragmented,":[102],"amplified,":[103],"ligated":[105],"adaptor/barcode":[107],"adapters.":[108],"The":[109,150,244],"libraries":[110],"purified":[112],"templates":[116],"prepared":[118],"on":[119,125],"Ion":[120,126],"316TM":[121],"chip":[122],"sequenced":[124],"Personal":[127],"Genome":[128],"Machine\u00ae":[129],"(PGM)":[130],"System.":[131],"Data":[132],"analyzed":[134],"integrated":[137],"Torrent":[138],"Variant":[139],"Caller":[140],"(TVC)":[141],"single":[143],"nucleotide":[144],"polymorphism":[145],"(SNP)":[146],"insertion/deletion":[148],"(Indel).":[149],"new":[151],"further":[154,191],"checked":[155],"confirmed":[157],"COSMIC":[159],"database.":[160],"In":[161,267],"comparisons":[162],"conventional":[164,221],"direct":[165,222],"sequencing,":[166],"NGS":[168,225,242,269],"assay":[169],"approach":[170,286],"provided":[171],"similar":[172],"accuracy":[173,184],"higher":[175],"sensitivity":[176],"all":[178],"six":[179],"celllines.":[180],"To":[181],"assess":[182],"barcoded":[186],"specimens":[187],"underrepresented":[189],"targets,":[190],"cross-dilution":[192],"performed":[194],"1:2":[196],"1:100-fold":[198],"dilutions":[199],"between":[200,220],"two":[201],"harboring":[204],"an":[205,284],"EGFR":[206],"exon":[207],"19":[208],"deletion":[209],"KRAS":[211],"G12":[212],"mutation.":[213],"showed":[217],"100%":[218],"concordance":[219],"assays":[226],"mutation":[228],"status":[229],"additional":[231],"somatic":[232],"detected":[235],"celllines":[237],"samples":[240],"method.":[243],"majority":[245],"clustered":[248],"TP53":[250],"(~70%),":[251],"other":[253],"KIT,":[256],"STK11,":[257],"AKT1,":[258],"ATM,":[259],"NRAS,":[260],"IDH1,":[261],"CDKN2A":[263],"also":[265],"identified.":[266],"summary,":[268],"method":[270,282],"not":[271],"only":[272],"can":[273],"be":[274],"a":[275],"robust,":[276],"sensitive,":[277],"reliable":[279],"laboratory":[281],"efficient":[285],"molecular":[288],"samples.":[292]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
