{"id":"https://openalex.org/W2426328331","doi":null,"title":"[Modifications of the enzymatic content and morphology of the exocrine pancreas of rats with experimental hepatic cirrhosis induced by thioacetamide].","display_name":"[Modifications of the enzymatic content and morphology of the exocrine pancreas of rats with experimental hepatic cirrhosis induced by thioacetamide].","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W2426328331","mag":"2426328331","pmid":"https://pubmed.ncbi.nlm.nih.gov/1723629"},"language":"es","primary_location":{"id":"pmid:1723629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1723629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anales de medicina interna (Madrid, Spain : 1984)","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M E Santamar\u00eda Gil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M E Santamar\u00eda Gil","raw_affiliation_strings":["Departamento de Medicina, Facultad de Medicina, Vallodolid"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Medicina, Facultad de Medicina, Vallodolid","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063039233","display_name":"M S de Andr\u00e9s Loste","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M S de Andr\u00e9s Loste","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M C Fern\u00e1ndez Alonso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C Fern\u00e1ndez Alonso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111414639","display_name":"E. Gonz\u00e1lez Fern\u00e1ndez","orcid":"https://orcid.org/0009-0001-9590-1674","observed_orcids":["https://orcid.org/0009-0001-9590-1674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Gonz\u00e1lez Fern\u00e1ndez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041202016","display_name":"F J Blanco Varela","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F J Blanco Varela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090438820","display_name":"M C Coca Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C Coca Garc\u00eda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112377465","display_name":"A. Caro-Pat\u00f3n G\u00f3mez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Caro-Pat\u00f3n G\u00f3mez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"12","first_page":"601","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.7900000214576721,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.7900000214576721,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.11959999799728394,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.045899998396635056,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/thioacetamide","display_name":"thioacetamide","score":0.8500000238418579},{"id":"https://openalex.org/keywords/exocrine-pancreas","display_name":"exocrine pancreas","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pancreatic-enzymes","display_name":"pancreatic enzymes","score":0.8339999914169312},{"id":"https://openalex.org/keywords/amylase","display_name":"amylase","score":0.9670000076293945},{"id":"https://openalex.org/keywords/lipase","display_name":"lipase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/trypsinogen","display_name":"trypsinogen","score":1.0},{"id":"https://openalex.org/keywords/duodenal-juice","display_name":"duodenal juice","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pancreatic-morphology","display_name":"pancreatic morphology","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C2781057625","wikidata":"https://www.wikidata.org/wiki/Q416253","display_name":"Thioacetamide","level":2,"score":0.8632033467292786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7805382013320923},{"id":"https://openalex.org/C170835558","wikidata":"https://www.wikidata.org/wiki/Q17153","display_name":"Amylase","level":3,"score":0.7790501117706299},{"id":"https://openalex.org/C2781286802","wikidata":"https://www.wikidata.org/wiki/Q421373","display_name":"Trypsinogen","level":4,"score":0.7732871174812317},{"id":"https://openalex.org/C2779697368","wikidata":"https://www.wikidata.org/wiki/Q380967","display_name":"Lipase","level":3,"score":0.773200273513794},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.6404151916503906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.63995361328125},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5466686487197876},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.5458467602729797},{"id":"https://openalex.org/C57380142","wikidata":"https://www.wikidata.org/wiki/Q863089","display_name":"Pancreatic juice","level":3,"score":0.5145063400268555},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.5107667446136475},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.4379195272922516},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.43022987246513367},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41118523478507996},{"id":"https://openalex.org/C2778677841","wikidata":"https://www.wikidata.org/wiki/Q422301","display_name":"Secretin","level":3,"score":0.4111674427986145},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.34072935581207275},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26674360036849976},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23104920983314514}],"mesh":[{"descriptor_ui":"D000681","descriptor_name":"Amylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008049","descriptor_name":"Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008106","descriptor_name":"Liver Cirrhosis, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008106","descriptor_name":"Liver Cirrhosis, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008106","descriptor_name":"Liver Cirrhosis, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013853","descriptor_name":"Thioacetamide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014362","descriptor_name":"Trypsinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1723629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1723629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anales de medicina interna (Madrid, Spain : 1984)","raw_type":"English Abstract"},{"id":"mag:2426328331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1723629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2419378960","https://openalex.org/W80728807","https://openalex.org/W2080972992","https://openalex.org/W1981773582","https://openalex.org/W7099882723","https://openalex.org/W2410664623","https://openalex.org/W2089239318","https://openalex.org/W2287642539","https://openalex.org/W2094787704","https://openalex.org/W2414247692"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,28],"assess":[3],"the":[4,84,99,107,125,129,136],"experimental":[5,119],"level":[6],"of":[7,13,21,37,41,71,81,115,124,135,139],"enzymatic":[8,126],"content":[9],"in":[10,48,57,77,83,95,106,118,128,133],"exocrine":[11],"pancreas":[12],"cirrhotic":[14,100],"rats,":[15],"cirrhosis":[16,120],"was":[17,75],"induced":[18],"with":[19,32,65,87],"administration":[20],"thioacetamide":[22],"(50":[23],"mg/kg)":[24],"during":[25],"ten":[26],"weeks":[27],"male":[29],"Wistar":[30],"rats":[31],"an":[33],"initial":[34],"average":[35],"weight":[36],"350":[38],"g.":[39],"Contents":[40],"amylase,":[42,52],"lipase":[43,53,82],"and":[44,51,54,63,73,80],"trypsinogen":[45,72],"were":[46,104],"determined":[47],"pancreatic":[49,78,130],"tissues":[50],"biliary":[55,96,116],"salts":[56,97,117],"duodenal":[58,85],"juice":[59],"obtained":[60],"by":[61],"cannulation":[62],"perfusion":[64],"physiologic":[66],"serum.":[67],"A":[68],"higher":[69],"presence":[70],"amylase":[74],"detected":[76],"tissues,":[79],"juice,":[86],"a":[88,93,113],"trend,":[89],"although":[90],"insignificant,":[91],"towards":[92],"decrease":[94],"among":[98],"group.":[101],"No":[102],"changes":[103],"observed":[105],"morphologic":[108],"study.":[109],"The":[110],"hypothesis":[111],"that":[112],"deficit":[114],"could":[121],"be":[122],"responsible":[123],"increase":[127],"tissue":[131],"and,":[132],"particular,":[134],"selective":[137],"excretion":[138],"lipase,":[140],"is":[141],"discussed.":[142]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}