{"id":"https://openalex.org/W2425895953","doi":null,"title":"Immunocytochemical detection of the 70-kd heat shock protein in alcoholic liver disease.","display_name":"Immunocytochemical detection of the 70-kd heat shock protein in alcoholic liver disease.","publication_year":1990,"publication_date":"1990-06-01","ids":{"openalex":"https://openalex.org/W2425895953","mag":"2425895953","pmid":"https://pubmed.ncbi.nlm.nih.gov/1693268"},"language":"en","primary_location":{"id":"pmid:1693268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1693268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of pathology & laboratory medicine","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"R Omar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Omar","raw_affiliation_strings":["Department of Pathology, West Virginia University School of Medicine, Morgantown 26506","WEST VIRGINIA UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, West Virginia University School of Medicine, Morgantown 26506","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"WEST VIRGINIA UNIVERSITY","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075232055","display_name":"Miguel A. Pappolla","orcid":"https://orcid.org/0000-0001-6637-3131","observed_orcids":["https://orcid.org/0000-0001-6637-3131"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Pappolla","raw_affiliation_strings":["WEST VIRGINIA UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WEST VIRGINIA UNIVERSITY","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088990199","display_name":"Bommakanti Saran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Saran","raw_affiliation_strings":["WEST VIRGINIA UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WEST VIRGINIA UNIVERSITY","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12097938"],"apc_list":null,"apc_paid":null,"fwci":1.1255,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.77875539,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"114","issue":"6","first_page":"589","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.8579999804496765},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.8870000243186951},{"id":"https://openalex.org/keywords/alcoholic-liver-disease","display_name":"alcoholic liver disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.753000020980835},{"id":"https://openalex.org/keywords/mallory-bodies","display_name":"Mallory bodies","score":0.9909999966621399},{"id":"https://openalex.org/keywords/intermediate-filaments","display_name":"intermediate filaments","score":0.7680000066757202},{"id":"https://openalex.org/keywords/ubiquitin","display_name":"ubiquitin","score":0.7570000290870667},{"id":"https://openalex.org/keywords/hepatocyte-injury","display_name":"hepatocyte injury","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cytoskeletal-damage","display_name":"cytoskeletal damage","score":0.5299999713897705},{"id":"https://openalex.org/keywords/immunocytochemistry","display_name":"immunocytochemistry","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.7430045008659363},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.5881251692771912},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.5081002712249756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4463368058204651},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.44424760341644287},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.4429774582386017},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44151920080184937},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.43612197041511536},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3704019784927368},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35873210430145264},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34501025080680847},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.145173579454422},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14431717991828918},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11111518740653992},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07171916961669922},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.054337531328201294}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008108","descriptor_name":"Liver Diseases, Alcoholic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1693268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1693268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of pathology & laboratory medicine","raw_type":"Journal Article"},{"id":"mag:2425895953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1693268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7799999713897705}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2332127184","https://openalex.org/W2002088863","https://openalex.org/W2199698661","https://openalex.org/W2084597643","https://openalex.org/W1995694098","https://openalex.org/W2084053616","https://openalex.org/W2068598925","https://openalex.org/W1991509345","https://openalex.org/W2119025780","https://openalex.org/W58742404"],"abstract_inverted_index":{"Exposure":[0],"of":[1,16,19,37,118,166,172,182,192],"cells":[2,149],"to":[3,54,76,162],"physical":[4],"(eg,":[5,9],"heat)":[6],"or":[7,68,90,153],"chemical":[8],"alcohol)":[10],"stress":[11],"results":[12],"in":[13,106,116,145,169],"increased":[14],"synthesis":[15],"a":[17,77,98,132,163,188],"set":[18],"highly":[20,43],"conserved":[21],"polypeptides":[22],"termed":[23],"heat":[24,67],"shock":[25],"proteins":[26,92],"(HSPs),":[27],"among":[28],"which":[29,109],"the":[30,38,170],"70-kd":[31],"protein":[32],"(HSP":[33],"70)":[34],"is":[35,52],"one":[36],"most":[39],"consistently":[40],"inducible":[41],"and":[42,51,85],"conserved.":[44],"This":[45],"HSP":[46,137,159,168,183],"has":[47,102],"adenosine":[48,79],"triphosphate-binding":[49],"properties":[50],"known":[53],"associate":[55],"strongly":[56],"with":[57,96,127],"cytoskeletal":[58],"structures":[59],"that":[60,83,179],"are":[61],"usually":[62],"disrupted":[63],"on":[64],"injury":[65],"by":[66],"alcohol.":[69],"Some":[70],"HSPs":[71],"apparently":[72],"function":[73],"as":[74,187],"accessories":[75],"nonlysosomal,":[78],"triphosphate-dependent":[80],"proteolytic":[81],"system":[82],"binds":[84],"digests":[86],"away":[87],"stress-generated":[88],"abnormal":[89],"denatured":[91],"after":[93],"their":[94],"conjugation":[95],"ubiquitin,":[97],"small":[99],"HSP.":[100],"Ubiquitin":[101],"been":[103],"demonstrated":[104],"immunocytochemically":[105],"Mallory":[107,151],"bodies,":[108],"represent":[110],"mainly":[111],"degenerated":[112],"intermediate":[113],"filaments":[114],"accumulated":[115],"hepatocytes":[117],"alcoholic-diseased":[119],"liver.":[120],"We":[121],"immunostained":[122],"histologic":[123],"sections":[124],"from":[125],"patients":[126],"alcoholic":[128,173],"liver":[129,174],"disease":[130],"using":[131],"polyclonal":[133],"antibody":[134],"raised":[135],"against":[136],"70.":[138],"Strong":[139],"diffuse":[140],"cytoplasmic":[141],"immunoreactivity":[142,157],"was":[143],"observed":[144],"many":[146],"hepatocytes,":[147],"including":[148],"without":[150],"bodies":[152],"fatty":[154],"degeneration.":[155],"Positive":[156],"for":[158],"70":[160,184],"points":[161],"possible":[164],"involvement":[165],"this":[167],"pathogenesis":[171],"disease.":[175],"It":[176],"also":[177],"suggests":[178],"immunocytochemical":[180],"detection":[181],"may":[185],"serve":[186],"more":[189],"sensitive":[190],"indicator":[191],"hepatocellular":[193],"injury.":[194]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
