{"id":"https://openalex.org/W2425892820","doi":null,"title":"A robust method for isotopic riboprobe in situ hybridisation to localise mRNAs in routine pathology specimens.","display_name":"A robust method for isotopic riboprobe in situ hybridisation to localise mRNAs in routine pathology specimens.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2425892820","mag":"2425892820","pmid":"https://pubmed.ncbi.nlm.nih.gov/9728289"},"language":"en","primary_location":{"id":"pmid:9728289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9728289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of histochemistry : EJH","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043932592","display_name":"Richard Poulsom","orcid":"https://orcid.org/0000-0001-8567-3543","observed_orcids":["https://orcid.org/0000-0001-8567-3543"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Poulsom","raw_affiliation_strings":["In Situ Hybridisation Service, Imperial Cancer Research Fund, London, UK. poulsom@icrf.icnet.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"In Situ Hybridisation Service, Imperial Cancer Research Fund, London, UK. poulsom@icrf.icnet.uk","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064470729","display_name":"Janet M. Longcroft","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Longcroft","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002329871","display_name":"Rosemary E. Jeffery","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R E Jeffery","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048218809","display_name":"L. A. Rogers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L A Rogers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019231390","display_name":"Jennifer H. Steel","orcid":"https://orcid.org/0000-0003-4439-0090","observed_orcids":["https://orcid.org/0000-0003-4439-0090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H Steel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.744,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.85032732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"42","issue":"2","first_page":"121","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-situ-hybridization","display_name":"in situ hybridization","score":0.8949999809265137},{"id":"https://openalex.org/keywords/mrna-localization","display_name":"mRNA localization","score":0.9860000014305115},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9580000042915344},{"id":"https://openalex.org/keywords/formalin-fixed-paraffin-embedded-tissue","display_name":"formalin-fixed paraffin-embedded tissue","score":0.9160000085830688},{"id":"https://openalex.org/keywords/quality-control","display_name":"quality control","score":0.7039999961853027},{"id":"https://openalex.org/keywords/drug-target-validation","display_name":"drug target validation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C2778837531","wikidata":"https://www.wikidata.org/wiki/Q7322394","display_name":"Riboprobe","level":5,"score":0.9355697631835938},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.694538414478302},{"id":"https://openalex.org/C3018290483","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridisation","level":3,"score":0.6137433052062988},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5638606548309326},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5461335182189941},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.49615153670310974},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48098599910736084},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4678286910057068},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4540071189403534},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3342099189758301},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2010950744152069},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1760057508945465},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1499273180961609},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007553","descriptor_name":"Isotope Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015347","descriptor_name":"RNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9728289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9728289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of histochemistry : EJH","raw_type":"Journal Article"},{"id":"mag:2425892820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9728289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2417092653","https://openalex.org/W139535977","https://openalex.org/W2052221787","https://openalex.org/W4388251208","https://openalex.org/W52248404","https://openalex.org/W2327528756","https://openalex.org/W4251577383","https://openalex.org/W1984510801","https://openalex.org/W2441946136","https://openalex.org/W1586108100"],"abstract_inverted_index":{"In":[0],"situ":[1,152],"Hybridisation":[2,153],"(ISH)":[3],"to":[4,10,28,44,77,114],"detect":[5],"mRNA":[6,54],"is":[7,32,35,69,144],"widely":[8],"applicable":[9],"studies":[11],"of":[12,50,52,138,160,172],"human":[13],"pathology":[14],"and":[15,89,140,143,178],"experimental":[16,141],"models":[17],"including":[18],"transgenic":[19],"mice,":[20],"where":[21,29],"it":[22,110],"can":[23,74,92],"provide":[24],"crucial":[25],"information":[26],"as":[27],"a":[30,86,108,122,130,136,166],"gene":[31],"expressed,":[33],"that":[34,46,72,90,133],"not":[36],"available":[37],"in":[38,60,107,121,151],"other":[39],"ways.":[40],"ISH":[41,73,91],"was":[42],"used":[43,76],"establish":[45],"relatively":[47],"high":[48,167],"levels":[49],"expression":[51],"E-cadherin":[53],"were":[55],"associated":[56],"with":[57,165],"long-term":[58],"survival":[59],"colorectal":[61],"cancer,":[62],"before":[63],"suitable":[64],"antisera":[65],"became":[66],"available.":[67],"There":[68],"increasing":[70],"awareness":[71],"be":[75,112],"help":[78,93],"select":[79],"between":[80],"candidate":[81],"disease":[82],"genes":[83,104],"found":[84],"at":[85],"linked":[87],"locus,":[88],"validate":[94],"therapeutic":[95],"targets.":[96],"For":[97],"instance,":[98],"when":[99],"several":[100],"closely":[101],"related":[102],"receptor":[103],"are":[105,118,176],"expressed":[106,119],"tissue,":[109],"may":[111],"possible":[113],"determine":[115],"which":[116],"combinations":[117],"together":[120],"single":[123],"cell":[124],"type.":[125],"These":[126],"diverse":[127],"applications":[128],"demand":[129],"robust":[131],"method":[132,175],"works":[134],"on":[135],"variety":[137],"clinical":[139],"materials,":[142],"easily":[145],"interpreted.":[146],"To":[147],"date,":[148],"the":[149],"ICRF":[150],"Service":[154],"has":[155],"hybridised":[156],"over":[157],"30,000":[158],"sections":[159],"principally":[161],"formalin-fixed,":[162],"paraffin-embedded":[163],"tissues,":[164],"success":[168],"rate.":[169],"The":[170],"practicalities":[171],"our":[173],"preferred":[174],"discussed":[177],"key":[179],"steps":[180],"for":[181],"quality":[182],"control":[183],"highlighted.":[184]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
