{"id":"https://openalex.org/W2425791736","doi":null,"title":"Synthesis and Selective Estrogen Receptor Binding Affinity of 7-Hydroxylisoflavones","display_name":"Synthesis and Selective Estrogen Receptor Binding Affinity of 7-Hydroxylisoflavones","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2425791736","mag":"2425791736"},"language":"en","primary_location":{"id":"pmh:oai:210.75.237.14:351003/23534","doi":null,"is_oa":false,"landing_page_url":"http://210.75.237.14/handle/351003/23534","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u671f\u520a\u8bba\u6587"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107519896","display_name":"Xing Wang","orcid":"https://orcid.org/0009-0000-3249-2095","observed_orcids":["https://orcid.org/0009-0000-3249-2095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xing Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Guangying Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guangying Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100617938","display_name":"Lijuan Yang","orcid":"https://orcid.org/0000-0002-7212-7110","observed_orcids":["https://orcid.org/0000-0002-7212-7110"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lijuan Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7212-7110","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104668693","display_name":"Wang Fei","orcid":"https://orcid.org/0000-0002-2675-2791","observed_orcids":["https://orcid.org/0000-0002-2675-2791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang Fei","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2675-2791","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101402122","display_name":"Chun Wang","orcid":"https://orcid.org/0000-0002-7069-6395","observed_orcids":["https://orcid.org/0000-0002-7069-6395"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang Chun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7069-6395","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1387,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.43344543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"31","issue":"8","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.7095000147819519,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.7095000147819519,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.2581000030040741,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isoflavones","display_name":"isoflavones","score":0.7549999952316284},{"id":"https://openalex.org/keywords/estrogen-receptor-binding-affinity","display_name":"estrogen receptor binding affinity","score":0.7170000076293945},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.7670000195503235},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.7620000243186951},{"id":"https://openalex.org/keywords/one-pot-synthesis","display_name":"one-pot synthesis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.6759999990463257},{"id":"https://openalex.org/keywords/phenylacetic-acid","display_name":"phenylacetic acid","score":0.8880000114440918},{"id":"https://openalex.org/keywords/demethylation","display_name":"demethylation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/substituent-effects","display_name":"substituent effects","score":0.6589999794960022},{"id":"https://openalex.org/keywords/relative-binding-affinity","display_name":"relative binding affinity","score":0.699999988079071},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C2778298627","wikidata":"https://www.wikidata.org/wiki/Q415957","display_name":"Genistein","level":2,"score":0.787101686000824},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7284471392631531},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.6358555555343628},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6195191740989685},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5517947673797607},{"id":"https://openalex.org/C96307122","wikidata":"https://www.wikidata.org/wiki/Q15329133","display_name":"Estrogen receptor beta","level":5,"score":0.5347321033477783},{"id":"https://openalex.org/C3018795828","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Binding affinities","level":3,"score":0.5238261818885803},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5031344294548035},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.5011470317840576},{"id":"https://openalex.org/C2779705811","wikidata":"https://www.wikidata.org/wiki/Q412519","display_name":"Isoflavones","level":2,"score":0.4870498478412628},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.46598735451698303},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.46513646841049194},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4296707808971405},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.36163246631622314},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2541671395301819},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17375731468200684},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15422853827476501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11549314856529236},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.05141109228134155},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:210.75.237.14:351003/23534","doi":null,"is_oa":false,"landing_page_url":"http://210.75.237.14/handle/351003/23534","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"\u671f\u520a\u8bba\u6587"},{"id":"mag:2425791736","doi":null,"is_oa":false,"landing_page_url":"http://www.irgrid.ac.cn/handle/1471x/517873","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2172622090","https://openalex.org/W2047209335","https://openalex.org/W2043348871","https://openalex.org/W2175051427","https://openalex.org/W2067150707","https://openalex.org/W2019602901","https://openalex.org/W2043489355","https://openalex.org/W7005918048","https://openalex.org/W1977793350","https://openalex.org/W2022287732"],"abstract_inverted_index":{"Twenty":[0],"six":[1],"7-hydroxylisoflavones,":[2],"including":[3],"four":[4],"new":[5],"compounds":[6,31,55],"3r,":[7],"3s,":[8],"3u":[9],"and":[10,32,38,46,94,104],"3v,":[11],"were":[12,23,40],"successfully":[13],"synthesized.":[14],"Among":[15],"which":[16],"twenty":[17],"four,":[18],"3a":[19],"similar":[20],"to":[21,100],"3x,":[22],"directly":[24],"given":[25],"by":[26,48],"\"One-Pot\"":[27],"strategy":[28],"from":[29,43],"polyphenolic":[30],"substituted":[33],"phenylacetic":[34],"acids.":[35],"2'-Hydroxylisoflavones":[36],"4a":[37],"4b":[39],"further":[41],"developed":[42],"2'-methoxylisoflvones":[44],"3d":[45],"3g":[47],"demethylation.":[49],"Nine":[50],"out":[51],"of":[52,77,84],"twenty-six":[53],"synthesized":[54],"exhibited":[56],"higher":[57],"selectivity":[58],"for":[59,71],"estrogen":[60],"receptor":[61],"ER":[62,72,85,102,105],"beta":[63],"than":[64,74],"genistein;":[65],"7,8-dihydroxylisoflavones":[66],"showed":[67],"better":[68],"binding":[69,81,98],"affinities":[70,82],"P":[73],"7-hydroxylisoflavones;":[75],"4'-substituents":[76],"isoflavones":[78],"influenced":[79],"relative":[80],"(RBA)":[83],"beta/ER":[86],"alpha":[87,103],"in":[88],"the":[89,97],"order:":[90],"H>Cl>F>OH;":[91],"2',":[92],"3'":[93],"5'-substituents":[95],"reduced":[96],"affinity":[99],"both":[101],"beta.":[106]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}