{"id":"https://openalex.org/W2425686069","doi":"https://doi.org/10.2174/1871523015666160922164224","title":"Reduction of eNOS in Vascular Smooth Muscle by Salt Independently of Hypertension","display_name":"Reduction of eNOS in Vascular Smooth Muscle by Salt Independently of Hypertension","publication_year":2016,"publication_date":"2016-09-28","ids":{"openalex":"https://openalex.org/W2425686069","doi":"https://doi.org/10.2174/1871523015666160922164224","mag":"2425686069","pmid":"https://pubmed.ncbi.nlm.nih.gov/27666396"},"language":"en","primary_location":{"id":"doi:10.2174/1871523015666160922164224","doi":"https://doi.org/10.2174/1871523015666160922164224","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1871523015666160922164224","pdf_url":"http://www.eurekaselect.com/article/78509","source":{"id":"https://openalex.org/S2764656217","display_name":"Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry","issn_l":"1568-0142","issn":["1568-0142","1871-5230","1875-6131","1875-614X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Inflammatory &amp; Anti-Allergy Agents in Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.eurekaselect.com/article/78509","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078944179","display_name":"Natalia L. Rukavina Mikusic","orcid":"https://orcid.org/0000-0002-5199-1129","observed_orcids":["https://orcid.org/0000-0002-5199-1129"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Natalia L. Rukavina Mikusic","raw_affiliation_strings":["Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina","Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina.,Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina.,Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082864682","display_name":"Mar\u00eda In\u00e9s Ros\u00f3n","orcid":"https://orcid.org/0000-0002-4985-2752","observed_orcids":["https://orcid.org/0000-0002-4985-2752"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Maria I. Roson","raw_affiliation_strings":["Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina","Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina; Departments of 2 Pathophysiology and 3 Pharmacology, School of Pharmacy and Biochemistry,","University of Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina; Departments of 2 Pathophysiology and 3 Pharmacology, School of Pharmacy and Biochemistry,","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"University of Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018148871","display_name":"Silvana Lorena Della Penna","orcid":"https://orcid.org/0000-0003-1739-4969","observed_orcids":["https://orcid.org/0000-0003-1739-4969"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Silvana L. Della Penna","raw_affiliation_strings":["Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina","Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina; Departments of 2 Pathophysiology and 3 Pharmacology, School of Pharmacy and Biochemistry,","University of Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina; Departments of 2 Pathophysiology and 3 Pharmacology, School of Pharmacy and Biochemistry,","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"University of Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017705835","display_name":"Marcelo R. Choi","orcid":"https://orcid.org/0000-0003-2909-8534","observed_orcids":["https://orcid.org/0000-0003-2909-8534"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Marcelo R. Choi","raw_affiliation_strings":["Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina","Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina","Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina; Departments of 2 Pathophysiology and 3 Pharmacology, School of Pharmacy and Biochemistry,","University of Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina; Departments of 2 Pathophysiology and 3 Pharmacology, School of Pharmacy and Biochemistry,","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"University of Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033142256","display_name":"Susana Beatriz Gorzalczany","orcid":"https://orcid.org/0000-0002-4744-5969","observed_orcids":["https://orcid.org/0000-0002-4744-5969"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Susana Gorzalczany","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina","cal Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"cal Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina;","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050006956","display_name":"Elsa Zotta","orcid":"https://orcid.org/0000-0002-8763-5046","observed_orcids":["https://orcid.org/0000-0002-8763-5046","https://orcid.org/0000-0001-6314-5264"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Elsa Zotta","raw_affiliation_strings":["Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina","cal Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]},{"raw_affiliation_string":"cal Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina;","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016174385","display_name":"Jorge Eduardo Toblli","orcid":"https://orcid.org/0000-0003-4401-6824","observed_orcids":["https://orcid.org/0000-0003-4401-6824"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Jorge E. Toblli","raw_affiliation_strings":["Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina","Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina; Departments of 2 Pathophysiology and 3 Pharmacology, School of Pharmacy and Biochemistry,","University of Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina; Departments of 2 Pathophysiology and 3 Pharmacology, School of Pharmacy and Biochemistry,","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"University of Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043185589","display_name":"Belisario Enrique Fern\u00e1ndez","orcid":"https://orcid.org/0000-0002-5672-1996","observed_orcids":["https://orcid.org/0000-0002-5672-1996"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Belisario E. Fernandez","raw_affiliation_strings":["Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina","Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina; Departments of 2 Pathophysiology and 3 Pharmacology, School of Pharmacy and Biochemistry,","University of Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"Cardiological Research Institute, National Council of Scientific and Technical Research, Buenos Aires, Argentina; Departments of 2 Pathophysiology and 3 Pharmacology, School of Pharmacy and Biochemistry,","institution_ids":["https://openalex.org/I151201029"]},{"raw_affiliation_string":"University of Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082864682"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313"],"apc_list":null,"apc_paid":null,"fwci":0.2397,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58411614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"15","issue":"2","first_page":"135","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"vascular smooth muscle","score":0.8629999756813049},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tempol","display_name":"tempol","score":0.6549999713897705},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.996999979019165},{"id":"https://openalex.org/keywords/aquaporin-1","display_name":"aquaporin-1","score":0.9409999847412109},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9480000138282776},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.6669999957084656},{"id":"https://openalex.org/keywords/small-arteries","display_name":"small arteries","score":0.8399999737739563},{"id":"https://openalex.org/keywords/sodium-overload","display_name":"sodium overload","score":0.652999997138977},{"id":"https://openalex.org/keywords/intimal-layer","display_name":"intimal layer","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.9623504877090454},{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.759823203086853},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.625340461730957},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5991294384002686},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5609698295593262},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.5128874778747559},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5073644518852234},{"id":"https://openalex.org/C2992676626","wikidata":"https://www.wikidata.org/wiki/Q408853","display_name":"Endothelial nitric oxide synthase","level":5,"score":0.49992895126342773},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.4891050457954407},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.48153191804885864},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4403202533721924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43691155314445496},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4354618787765503},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.39747148752212524},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.2586630582809448},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.18690907955169678}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2174/1871523015666160922164224","doi":"https://doi.org/10.2174/1871523015666160922164224","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1871523015666160922164224","pdf_url":"http://www.eurekaselect.com/article/78509","source":{"id":"https://openalex.org/S2764656217","display_name":"Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry","issn_l":"1568-0142","issn":["1568-0142","1871-5230","1875-6131","1875-614X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Inflammatory &amp; Anti-Allergy Agents in Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:27666396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27666396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-inflammatory & anti-allergy agents in medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/41845","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/41845","pdf_url":null,"source":{"id":"https://openalex.org/S4306402455","display_name":"CONICET Digital (CONICET)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210148385","host_organization_name":"Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society","host_organization_lineage":["https://openalex.org/I4210148385"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2174/1871523015666160922164224","doi":"https://doi.org/10.2174/1871523015666160922164224","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1871523015666160922164224","pdf_url":"http://www.eurekaselect.com/article/78509","source":{"id":"https://openalex.org/S2764656217","display_name":"Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry","issn_l":"1568-0142","issn":["1568-0142","1871-5230","1875-6131","1875-614X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Inflammatory &amp; Anti-Allergy Agents in Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2439265903","display_name":null,"funder_award_id":"CONICET","funder_id":"https://openalex.org/F4320323257","funder_display_name":"Universidad de Buenos Aires"},{"id":"https://openalex.org/G2842638335","display_name":null,"funder_award_id":"20020100100688","funder_id":"https://openalex.org/F4320323257","funder_display_name":"Universidad de Buenos Aires"},{"id":"https://openalex.org/G3998373107","display_name":null,"funder_award_id":"PIP 1337","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"},{"id":"https://openalex.org/G4615730536","display_name":null,"funder_award_id":"20020110200048","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"},{"id":"https://openalex.org/G637338350","display_name":null,"funder_award_id":"UBACYT B113","funder_id":"https://openalex.org/F4320323257","funder_display_name":"Universidad de Buenos Aires"},{"id":"https://openalex.org/G8592701990","display_name":null,"funder_award_id":"20020110200048","funder_id":"https://openalex.org/F4320323257","funder_display_name":"Universidad de Buenos Aires"}],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320323257","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513"},{"id":"https://openalex.org/F4320335478","display_name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2425686069.pdf","grobid_xml":"https://content.openalex.org/works/W2425686069.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1965491619","https://openalex.org/W1978804120","https://openalex.org/W1984169833","https://openalex.org/W1985730052","https://openalex.org/W1987895314","https://openalex.org/W2003937418","https://openalex.org/W2006703181","https://openalex.org/W2016204376","https://openalex.org/W2020532593","https://openalex.org/W2022106942","https://openalex.org/W2022533265","https://openalex.org/W2023266267","https://openalex.org/W2029394858","https://openalex.org/W2035367937","https://openalex.org/W2037618202","https://openalex.org/W2042111014","https://openalex.org/W2042642188","https://openalex.org/W2050183202","https://openalex.org/W2050797367","https://openalex.org/W2052932344","https://openalex.org/W2055852663","https://openalex.org/W2058902834","https://openalex.org/W2074618102","https://openalex.org/W2077281334","https://openalex.org/W2085993508","https://openalex.org/W2099952789","https://openalex.org/W2116809022","https://openalex.org/W2120612885","https://openalex.org/W2131175622","https://openalex.org/W2134441749","https://openalex.org/W2148410073","https://openalex.org/W2151208929","https://openalex.org/W2153615786","https://openalex.org/W2155725055","https://openalex.org/W2157836756","https://openalex.org/W2166352678","https://openalex.org/W4253744295"],"related_works":["https://openalex.org/W2034786593","https://openalex.org/W2160414655","https://openalex.org/W2115648058","https://openalex.org/W2144885797","https://openalex.org/W2415290605","https://openalex.org/W2092368189","https://openalex.org/W1042412218","https://openalex.org/W4417357319","https://openalex.org/W2369377083","https://openalex.org/W2323128464"],"abstract_inverted_index":{"BACKGROUND:":[0],"Endothelial":[1],"nitric":[2],"oxide":[3],"synthase":[4],"(eNOS)":[5],"is":[6,225],"known":[7],"to":[8,25,120,159,203],"be":[9],"expressed":[10],"in":[11,31,144,153,169,192,214,241],"endothelium":[12],"and":[13,33,46,51,88,107,111,126,141,149,163,167,174,199,221],"smooth":[14,216],"muscle":[15,217],"cells":[16],"of":[17,21,29,36,116,124,172,176,186,196,219,235,249],"arteries.":[18],"The":[19],"aim":[20],"this":[22],"study":[23],"was":[24,96],"investigate":[26],"the":[27,99,108,122,145,154,170,177,184,193,197],"expression":[28,123,171,185,213],"eNOS":[30,125,140,151,173,187,212,240],"intimal":[32,147,178],"medial":[34,156,194],"layer":[35,195],"aorta":[37,110,146,155,198,220],"from":[38],"rats":[39,242],"fed":[40,56,243],"with":[41],"a":[42,244],"high":[43,67,208,245],"salt":[44,62,68,209,246],"diet":[45,63,69,210,247],"its":[47],"modulation":[48],"by":[49,98,129,189,227],"losartan":[50,85,91],"tempol.":[52,228],"METHODS:":[53],"Rats":[54,103],"were":[55,104,118],"during":[57],"three":[58],"weeks":[59],"with:":[60],"normal":[61],"(NS,":[64],"0.4%":[65],"NaCl);":[66,72],"(HS,":[70],"8%":[71],"NS":[73,83,160],"plus":[74,80,84,90],"tempol":[75,81,164,182],"1":[76],"mM":[77],"(NS-T);":[78],"HS":[79,89,132,204],"(HS-T);":[82],"40mg.kg-1":[86],"(NS-L)":[87],"(HS-L).":[92],"Systolic":[93],"blood":[94,137],"pressure":[95],"recorded":[97],"tail":[100],"cuff":[101],"method.":[102],"then":[105],"anaesthetized":[106],"thoracic":[109],"small":[112,200,222],"arteries":[113,201],"(bronchial":[114],"branches":[115],"aorta)":[117],"processed":[119],"evaluate":[121],"aquaporin-1":[127],"(AQP-1)":[128],"immunohistochemistry.":[130],"RESULTS:":[131],"group":[133],"showed":[134],"increased":[135,139,183],"systolic":[136],"pressure,":[138],"AQP-1":[142,175],"immunoexpression":[143,152],"layer,":[148,157],"decreased":[150],"respect":[158,202],"group.":[161,205],"Losartan":[162],"prevented":[165],"hypertension":[166],"changes":[168],"layer.":[179],"However,":[180],"only":[181],"elicited":[188],"sodium":[190],"overload":[191],"CONCLUSIONS:":[206],"A":[207],"decreases":[211],"vascular":[215,239],"layers":[218],"arteries,":[223],"which":[224],"reversed":[226],"These":[229],"results":[230],"suggest":[231],"an":[232],"adverse":[233],"effect":[234],"oxidative":[236],"stress":[237],"on":[238],"independently":[248],"hypertension.":[250]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
