{"id":"https://openalex.org/W2425622228","doi":"https://doi.org/10.1016/s0026-895x(25)14401-5","title":"Functional Alterations in Components of Pigeon Erythrocyte Adenylate Cyclase following Desensitization to Isoproterenol","display_name":"Functional Alterations in Components of Pigeon Erythrocyte Adenylate Cyclase following Desensitization to Isoproterenol","publication_year":1981,"publication_date":"1981-11-01","ids":{"openalex":"https://openalex.org/W2425622228","doi":"https://doi.org/10.1016/s0026-895x(25)14401-5","mag":"2425622228","pmid":"https://pubmed.ncbi.nlm.nih.gov/7329410"},"language":"en","primary_location":{"id":"doi:10.1016/s0026-895x(25)14401-5","doi":"https://doi.org/10.1016/s0026-895x(25)14401-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0026-895x(25)14401-5","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110253929","display_name":"Thomas H. Hudson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"THOMAS H. HUDSON","raw_affiliation_strings":["Section of Physiological Chemistry, Division of Biology and Medicine, Brown University, Providence Rhode Island 02912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Physiological Chemistry, Division of Biology and Medicine, Brown University, Providence Rhode Island 02912","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047612906","display_name":"Gary L. Johnson","orcid":"https://orcid.org/0000-0003-2867-0551","observed_orcids":["https://orcid.org/0000-0003-2867-0551"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"GARY L. JOHNSON","raw_affiliation_strings":["Section of Physiological Chemistry, Division of Biology and Medicine, Brown University, Providence Rhode Island 02912"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Physiological Chemistry, Division of Biology and Medicine, Brown University, Providence Rhode Island 02912","institution_ids":["https://openalex.org/I27804330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27804330"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":1.7775,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.84972667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"3","first_page":"694","last_page":"703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.8199999928474426},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.8410000205039978},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.996999979019165},{"id":"https://openalex.org/keywords/pigeon-erythrocytes","display_name":"pigeon erythrocytes","score":0.8339999914169312},{"id":"https://openalex.org/keywords/g-proteins","display_name":"G proteins","score":0.7269999980926514},{"id":"https://openalex.org/keywords/guanine-nucleotide-regulatory-protein","display_name":"guanine nucleotide regulatory protein","score":0.7490000128746033},{"id":"https://openalex.org/keywords/dihydroalprenolol-binding","display_name":"dihydroalprenolol binding","score":0.8220000267028809},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.8477246761322021},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.7902072072029114},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.6584438681602478},{"id":"https://openalex.org/C2777995097","wikidata":"https://www.wikidata.org/wiki/Q422462","display_name":"Guanosine","level":2,"score":0.6308779120445251},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.6229101419448853},{"id":"https://openalex.org/C2778301229","wikidata":"https://www.wikidata.org/wiki/Q169313","display_name":"Guanine","level":4,"score":0.6169587969779968},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.599087119102478},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5891910791397095},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5489414930343628},{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.5155705809593201},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4589501619338989},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3637309670448303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29074129462242126},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21832981705665588},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.17541250586509705},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004082","descriptor_name":"Dihydroalprenolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004910","descriptor_name":"Erythrocyte Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010856","descriptor_name":"Columbidae","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0026-895x(25)14401-5","doi":"https://doi.org/10.1016/s0026-895x(25)14401-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0026-895x(25)14401-5","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmid:7329410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7329410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.975.4216","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.975.4216","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://molpharm.aspetjournals.org/content/20/3/694.full.pdf","raw_type":"text"},{"id":"mag:2425622228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7329410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W3220325","https://openalex.org/W182982796","https://openalex.org/W1486528004","https://openalex.org/W1487878207","https://openalex.org/W1488907873","https://openalex.org/W1547578399","https://openalex.org/W1555589103","https://openalex.org/W1589012184","https://openalex.org/W1592735689","https://openalex.org/W1606423922","https://openalex.org/W1775749144","https://openalex.org/W1965833276","https://openalex.org/W2024296404","https://openalex.org/W2100837269","https://openalex.org/W2128565639","https://openalex.org/W2397456260"],"related_works":["https://openalex.org/W2094959748","https://openalex.org/W317487152","https://openalex.org/W1487646074","https://openalex.org/W2006109063","https://openalex.org/W2473208793","https://openalex.org/W2407397979","https://openalex.org/W1543409245","https://openalex.org/W1990471921","https://openalex.org/W2421055941","https://openalex.org/W1988015916"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}