{"id":"https://openalex.org/W2425494191","doi":null,"title":"Comparison of the influence of dihydroergotoxine on cerebral oxygenation in the normoxic and hypercapnic hypoxic dog.","display_name":"Comparison of the influence of dihydroergotoxine on cerebral oxygenation in the normoxic and hypercapnic hypoxic dog.","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W2425494191","mag":"2425494191","pmid":"https://pubmed.ncbi.nlm.nih.gov/4094451"},"language":"en","primary_location":{"id":"pmid:4094451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4094451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal de pharmacologie","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000879312","display_name":"Van den Driessche J","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Van den Driessche","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111604645","display_name":"H. Allain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Allain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079765857","display_name":"Dani\u00e8le Bentu\u00e9\u2010Ferrer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Bentu\u00e9-Ferrer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004134997","display_name":"Alain Feuillu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Feuillu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082928646","display_name":"Danielle Pape","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Pape","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001073977","display_name":"Dominique Milon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Milon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109953202","display_name":"Jean\u2010Michel Reymann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Reymann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16 Suppl 3","issue":null,"first_page":"85","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.3686999976634979,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.3686999976634979,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.17980000376701355,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.17880000174045563,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dihydroergotoxine","display_name":"dihydroergotoxine","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cerebral-oxygenation","display_name":"cerebral oxygenation","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cerebral-metabolic-rate-for-oxygen","display_name":"cerebral oxygen consumption","score":0.6620000004768372},{"id":"https://openalex.org/keywords/hypercapnic-hypoxia","display_name":"hypercapnic hypoxia","score":0.9679999947547913},{"id":"https://openalex.org/keywords/normoxia","display_name":"normoxia","score":0.7860000133514404},{"id":"https://openalex.org/keywords/oxygen-extraction-fraction","display_name":"oxygen extraction fraction","score":0.824999988079071},{"id":"https://openalex.org/keywords/arteriovenous-oxygen-difference","display_name":"arteriovenous oxygen difference","score":0.8460000157356262},{"id":"https://openalex.org/keywords/vertebral-artery","display_name":"vertebral artery","score":0.4580000042915344},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.46799999475479126},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.9580000042915344},{"id":"https://openalex.org/keywords/blood-ph","display_name":"blood pH","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6528224349021912},{"id":"https://openalex.org/C2777140959","wikidata":"https://www.wikidata.org/wiki/Q10343041","display_name":"pCO2","level":2,"score":0.6335021257400513},{"id":"https://openalex.org/C2776725644","wikidata":"https://www.wikidata.org/wiki/Q594365","display_name":"Chloralose","level":3,"score":0.5857011079788208},{"id":"https://openalex.org/C70289976","wikidata":"https://www.wikidata.org/wiki/Q17143603","display_name":"Oxygenation","level":2,"score":0.5559520721435547},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5079911351203918},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.503081738948822},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.4957798421382904},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4322251081466675},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.4252774715423584},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4138067662715912},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3270011842250824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32047373056411743},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31573495268821716},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.30351927876472473},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.27690988779067993},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004088","descriptor_name":"Dihydroergotoxine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008173","descriptor_name":"Lung Diseases, Obstructive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4094451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4094451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal de pharmacologie","raw_type":"Comparative Study"},{"id":"mag:2425494191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4094451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1979118796","https://openalex.org/W2100222163","https://openalex.org/W2009135374","https://openalex.org/W2132677588","https://openalex.org/W3030058724","https://openalex.org/W2409875423","https://openalex.org/W2090979122","https://openalex.org/W2032065818","https://openalex.org/W2152134517","https://openalex.org/W2411062765"],"abstract_inverted_index":{"50":[0],"bastard":[1],"dogs":[2],"are":[3,48,76,127,149],"anesthetized":[4],"by":[5,16,151,191],"chloralose":[6],"(100":[7],"mg/kg)":[8,12],"and":[9,13,39,45,72,115,134,146,160,206],"mebubarbital":[10],"(5":[11],"then":[14],"perfused":[15],"three-different":[17],"dosages":[18],"of":[19,28,99,107,118,132,164,178,181],"dihydroergotoxine":[20],"(DHET)":[21],"(1.25;":[22],"2.5;":[23],"5":[24,123],"micrograms/kg/min).":[25],"The":[26,42],"effect":[27,198,209],"DHET":[29,152,171],"on":[30,158,203],"cerebral":[31,85],"oxygenation":[32],"is":[33,120,136,190,210],"analyzed":[34],"under":[35],"two":[36],"conditions:":[37],"normoxia":[38],"hypercapnic":[40],"hypoxia.":[41],"following":[43],"biochemical":[44],"physiological":[46],"parameters":[47,75],"studied:":[49],"mean":[50],"vertebral":[51,88],"flow":[52],"(MVF),":[53],"aortic":[54],"arterial":[55],"pressure":[56],"(AP),":[57],"heart":[58],"rate":[59],"(HR);":[60],"pO2,":[61],"pCO2,":[62],"total":[63],"CO2,":[64],"pH,":[65],"haemoglobin":[66],"saturation":[67],"ratio,":[68],"both":[69],"in":[70,213],"arteries":[71],"veins.":[73],"Other":[74],"calculated:":[77],"O2":[78,82,86],"arterio-venous":[79,142],"difference,":[80],"CMRO2,":[81,174],"extraction":[83,184],"coefficient,":[84],"supply,":[87],"resistance.":[89],"Under":[90,139],"normoxia,":[91],"DHET,":[92],"whatever":[93],"the":[94,100,130,141,147,165,173,182],"dosage,":[95],"induces":[96],"a":[97,113,176],"decrease":[98,106,131],"MVF":[101,161],"associated":[102],"with":[103],"an":[104,179],"inconstant":[105],"oxygen":[108,143,183],"supply.":[109],"At":[110,122],"2.5":[111,187],"micrograms/kg/min,":[112,124],"permanent":[114],"significant":[116],"increase":[117,180],"CMRO2":[119,148],"obtained.":[121],"similar":[125],"results":[126],"obtained":[128,212],"although":[129],"HR":[133],"AP":[135,159,205],"more":[137],"pronounced.":[138],"hypoxia,":[140],"content":[144],"difference":[145],"increased":[150],"(2.5":[153],"micrograms/kg/min)":[154],"without":[155,199,215],"any":[156,200,216],"repercussions":[157],"(hypothetical":[162],"role":[163],"blood":[166],"pH":[167],"decrease).":[168],"In":[169],"conclusion,":[170],"doubles":[172],"as":[175],"consequence":[177],"ratio.":[185],"A":[186],"micrograms/kg/min":[188],"dosage":[189],"itself":[192],"able":[193],"to":[194],"give":[195],"this":[196],"maximum":[197],"major":[201],"consequences":[202],"HR,":[204],"MVF.":[207],"This":[208],"still":[211],"hypoxia":[214],"peripheral":[217],"vascular":[218],"effect.":[219]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
