{"id":"https://openalex.org/W2425463572","doi":"https://doi.org/10.3760/cma.j.issn.0253-2727.2015.06.004","title":"[Involvement of oxidative stress in embelin-induced cell death in leukemia HL-60 cells].","display_name":"[Involvement of oxidative stress in embelin-induced cell death in leukemia HL-60 cells].","publication_year":2015,"publication_date":"2015-06-01","ids":{"openalex":"https://openalex.org/W2425463572","doi":"https://doi.org/10.3760/cma.j.issn.0253-2727.2015.06.004","mag":"2425463572","pmid":"https://pubmed.ncbi.nlm.nih.gov/26134009"},"language":"en","primary_location":{"id":"pmid:26134009","doi":"https://doi.org/10.3760/cma.j.issn.0253-2727.2015.06.004","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26134009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7343066","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117154148","display_name":"Ying Yang","orcid":"https://orcid.org/0000-0003-2679-1755","observed_orcids":["https://orcid.org/0000-0003-2679-1755"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Yang","raw_affiliation_strings":["Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100783995","display_name":"Rong Hu","orcid":"https://orcid.org/0000-0002-2992-5539","observed_orcids":["https://orcid.org/0000-0002-2992-5539"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Hu","raw_affiliation_strings":["Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101748361","display_name":"Ke Zhu","orcid":"https://orcid.org/0000-0003-1794-1328","observed_orcids":["https://orcid.org/0000-0003-1794-1328"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Zhu","raw_affiliation_strings":["Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404268","display_name":"Yingchun Li","orcid":"https://orcid.org/0009-0006-4492-0345","observed_orcids":["https://orcid.org/0009-0006-4492-0345"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingchun Li","raw_affiliation_strings":["Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100768805","display_name":"Jia Li","orcid":"https://orcid.org/0000-0002-3148-6897","observed_orcids":["https://orcid.org/0000-0002-3148-6897"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Li","raw_affiliation_strings":["Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100693077","display_name":"Miao Miao","orcid":"https://orcid.org/0009-0002-2829-7750","observed_orcids":["https://orcid.org/0009-0002-2829-7750"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miao Miao","raw_affiliation_strings":["Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101653653","display_name":"Hongtao Wang","orcid":"https://orcid.org/0000-0002-8677-3164","observed_orcids":["https://orcid.org/0000-0002-8677-3164"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongtao Wang","raw_affiliation_strings":["Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101454286","display_name":"Kun Yao","orcid":"https://orcid.org/0000-0003-0687-6997","observed_orcids":["https://orcid.org/0000-0003-0687-6997"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Yao","raw_affiliation_strings":["Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103046638","display_name":"Zhuogang Liu","orcid":"https://orcid.org/0000-0001-9741-2666","observed_orcids":["https://orcid.org/0000-0001-9741-2666"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuogang Liu","raw_affiliation_strings":["Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang\u3000110023, China","institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Hematological Department of Shengjing Hospital Affiliated to China Medical University, Shenyang 110023, China","institution_ids":["https://openalex.org/I91656880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5444,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.83227928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"36","issue":"6","first_page":"465","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.6615999937057495,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.6615999937057495,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0843999981880188,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.07999999821186066,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/embelin","display_name":"embelin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9769999980926514},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8230000138282776},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.8830000162124634},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7549999952316284},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.8880000114440918},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9129999876022339},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8154870271682739},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7267357707023621},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6770274639129639},{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.6692533493041992},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6423310041427612},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6231715083122253},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5775591135025024},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5675268173217773},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4767944812774658},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.46847406029701233},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.430791974067688},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3415584862232208},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19617649912834167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15846368670463562}],"mesh":[{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000111","descriptor_name":"Acetylcysteine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005452","descriptor_name":"Fluoresceins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005452","descriptor_name":"Fluoresceins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005452","descriptor_name":"Fluoresceins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005452","descriptor_name":"Fluoresceins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016227","descriptor_name":"Benzoquinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016227","descriptor_name":"Benzoquinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016227","descriptor_name":"Benzoquinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016227","descriptor_name":"Benzoquinones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:26134009","doi":"https://doi.org/10.3760/cma.j.issn.0253-2727.2015.06.004","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26134009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7343066","doi":"https://doi.org/10.3760/cma.j.issn.0253-2727.2015.06.004","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7343066","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua Xue Ye Xue Za Zhi","raw_type":"Text"},{"id":"mag:2425463572","doi":"https://doi.org/10.3760/cma.j.issn.0253-2727.2015.06.004","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26134009","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7343066","doi":"https://doi.org/10.3760/cma.j.issn.0253-2727.2015.06.004","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7343066","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua Xue Ye Xue Za Zhi","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6399999856948853,"display_name":"Life below water","id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1967680329","https://openalex.org/W1973206036","https://openalex.org/W1980667131","https://openalex.org/W1995396857","https://openalex.org/W1996313523","https://openalex.org/W2011006339","https://openalex.org/W2039179414","https://openalex.org/W2066578195","https://openalex.org/W2070478465","https://openalex.org/W2129916963","https://openalex.org/W2145466597","https://openalex.org/W2154065774","https://openalex.org/W2167417479","https://openalex.org/W2169961966","https://openalex.org/W2219978888","https://openalex.org/W2421670004"],"related_works":["https://openalex.org/W4289205112","https://openalex.org/W2379624126","https://openalex.org/W2387549746","https://openalex.org/W2005283836","https://openalex.org/W1485899361","https://openalex.org/W2390971425","https://openalex.org/W2554658078","https://openalex.org/W2377878450","https://openalex.org/W2375640902","https://openalex.org/W1992494324"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,11,67,83,92,146,169,176,182,187],"effects":[4,43],"of":[5,13,69,75,85,114,119,171,178,189],"Embelin":[6,27,72,108,142,167],"on":[7,16],"HL-60":[8,22,76,124,172],"cells":[9,23,77,125,173],"by":[10,46,56,174],"impact":[12],"oxidative":[14,183],"stress":[15],"DNA":[17,120,190],"double-strain":[18],"breaks":[19],"(DSBs).":[20],"METHODS:":[21],"were":[24,54,126],"treated":[25,138],"with":[26,128,139],"in":[28,78],"different":[29],"concentration":[30,84],"(3,":[31],"10,":[32,86],"30,":[33,87],"100,":[34,88],"and":[35,41,89,103,117,136,151,181],"300":[36,90,140],"\u03bcg/ml)":[37],"for":[38,133,143],"24":[39,144],"h,":[40,145],"inhibitory":[42],"was":[44,63,95],"examined":[45],"CCK-8":[47],"assay.":[48],"Reactive":[49],"oxygen":[50],"species":[51],"(ROS)":[52],"levels":[53],"evaluated":[55],"flow":[57],"cytometry":[58],"using":[59],"DCFH-DA.":[60],"Comet":[61],"assay":[62],"used":[64],"to":[65,111,161],"detect":[66],"extent":[68],"DSBs.":[70],"RESULTS:":[71],"inhibited":[73],"proliferation":[74],"a":[79],"dose-dependent":[80],"manner.":[81],"At":[82],"\u03bcg/ml,":[91],"inhibition":[93],"rate":[94],"(12.74":[96],"\u00b1":[97,100,105,163],"2.27)%,":[98],"(23.49":[99],"1.96)%,":[101],"(30.30\u00b11.89)%,":[102],"(57.55":[104],"3.59)%":[106],"(P<0.05).":[107,122,154,165],"also":[109],"lead":[110],"high":[112],"level":[113,149],"intracellular":[115,147,179],"ROS":[116,129,148],"deterioration":[118],"damage":[121,188],"When":[123],"pretreated":[127],"scavenger":[130],"N-acetyl-l-cysteine":[131],"(NAC)":[132],"2":[134],"h":[135],"then":[137],"\u03bcg/ml":[141],"declined":[150,160],"DSBs":[152],"relieved":[153],"Meanwhile,":[155],"embelin-induced":[156],"cell":[157],"viability":[158],"significantly":[159],"(32.75":[162],"2.70)%":[164],"CONCLUSION:":[166],"induced":[168],"death":[170],"increasing":[175],"generation":[177],"oxidation":[180],"stress,":[184],"which":[185],"drived":[186],"double-strand.":[191]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
