{"id":"https://openalex.org/W2425405284","doi":null,"title":"[Human acid secretion during daily administration of H2-blockers].","display_name":"[Human acid secretion during daily administration of H2-blockers].","publication_year":1984,"publication_date":"1984-05-12","ids":{"openalex":"https://openalex.org/W2425405284","mag":"2425405284","pmid":"https://pubmed.ncbi.nlm.nih.gov/6330886"},"language":"de","primary_location":{"id":"pmid:6330886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6330886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schweizerische medizinische Wochenschrift","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018897319","display_name":"Peter K M\u00fcller","orcid":"https://orcid.org/0000-0003-4113-5043","observed_orcids":["https://orcid.org/0000-0003-4113-5043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P M\u00fcller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006595345","display_name":"Bernard M. Simon","orcid":"https://orcid.org/0000-0001-7922-4418","observed_orcids":["https://orcid.org/0000-0001-7922-4418"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Simon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065580771","display_name":"Dammann Hg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H G Dammann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000617319","display_name":"G. E. Feurle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Feurle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073760669","display_name":"KLAUS LICHTWALD","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Lichtwald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009674344","display_name":"H Schmidt-Gayk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Schmidt-Gayk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5517,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.95433333,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"114","issue":"19","first_page":"667","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-acid-secretion","display_name":"gastric acid secretion","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ranitidine","display_name":"ranitidine","score":0.8730000257492065},{"id":"https://openalex.org/keywords/famotidine","display_name":"famotidine","score":1.0},{"id":"https://openalex.org/keywords/h2-receptor-antagonists","display_name":"H2 receptor antagonists","score":0.8970000147819519},{"id":"https://openalex.org/keywords/basal-acid-secretion","display_name":"basal acid secretion","score":0.6740000247955322},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.6840000152587891},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.7770000100135803},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C2781263782","wikidata":"https://www.wikidata.org/wiki/Q411159","display_name":"Famotidine","level":2,"score":0.9373940229415894},{"id":"https://openalex.org/C2777445857","wikidata":"https://www.wikidata.org/wiki/Q423037","display_name":"Ranitidine","level":2,"score":0.7580610513687134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7313545346260071},{"id":"https://openalex.org/C2777504413","wikidata":"https://www.wikidata.org/wiki/Q846270","display_name":"Gastric acid","level":3,"score":0.7033413648605347},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6950183510780334},{"id":"https://openalex.org/C2779377912","wikidata":"https://www.wikidata.org/wiki/Q423586","display_name":"Pentagastrin","level":4,"score":0.630613386631012},{"id":"https://openalex.org/C2778537899","wikidata":"https://www.wikidata.org/wiki/Q254034","display_name":"Bedtime","level":2,"score":0.613743782043457},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5989208221435547},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.513782799243927},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.48094314336776733},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.469157338142395},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.44410279393196106},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2825554609298706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14538100361824036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09105789661407471},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08133262395858765},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.05906188488006592}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005744","descriptor_name":"Gastric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010418","descriptor_name":"Pentagastrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011899","descriptor_name":"Ranitidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015738","descriptor_name":"Famotidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6330886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6330886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Schweizerische medizinische Wochenschrift","raw_type":"Clinical Trial"},{"id":"mag:2425405284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6330886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2105921599","https://openalex.org/W2005136924","https://openalex.org/W2068223022","https://openalex.org/W2090283923","https://openalex.org/W2463024493","https://openalex.org/W1971854684","https://openalex.org/W1978109860","https://openalex.org/W2404012395","https://openalex.org/W1990033072","https://openalex.org/W1990887724"],"abstract_inverted_index":{"The":[0],"potency":[1],"and":[2,10,34,42,55,63,76,125,159,168,195],"duration":[3],"of":[4,8,21,26,184,210],"a":[5,22,44,202],"single":[6,23,203],"dose":[7,25,205],"ranitidine":[9,62],"famotidine":[11,27,66,123,156,192,196],"were":[12,188],"compared":[13],"in":[14,206],"placebo-controlled":[15],"studies.":[16],"In":[17],"addition,":[18],"the":[19,144,154,207],"effect":[20,93],"night-time":[24,204],"(40":[28],"mg)":[29],"on":[30,94],"gastric":[31,102,174],"acid":[32,48,69,96,161,175],"secretion":[33,49,84,97,162],"basal":[35,83,158],"hormone":[36],"levels":[37,183],"was":[38,50,71,85,105,163],"assessed":[39],"before,":[40],"during":[41,143],"after":[43,59,80,153],"28-day":[45,191],"treatment.":[46,193],"Basal":[47,182],"depressed":[51],"by":[52,73,88,119,133,165,190],"about":[53,74,89],"73%":[54],"76%":[56],"12":[57,151],"hours":[58,79,152],"300":[60,134],"mg":[61,65,121,135],"40":[64,120],"respectively.":[67,170],"Pentagastrin-stimulated":[68],"output":[70,176],"reduced":[72,140,164],"26%":[75,169],"29%.":[77],"20":[78],"both":[81],"drugs,":[82],"still":[86],"inhibited":[87,106],"60%,":[90],"whereas":[91],"no":[92],"stimulated":[95,160],"could":[98],"be":[99,199],"detected.":[100],"Nocturnal":[101],"acidity":[103],"(23.00-07.00)":[104],"from":[107],"35.8":[108],"+/-":[109,114,128],"4.6":[110],"mmol/l":[111,116,130],"to":[112,126,179],"1.8":[113],"0.5":[115,129],"(94%":[117],"inhibition)":[118,132],"bedtime":[122],",":[124],"1.7":[127],"(95%":[131],"ranitidine.":[136],"Both":[137],"drugs":[138],"significantly":[139],"H+":[141],"concentrations":[142],"following":[145],"day.":[146],"On":[147,171],"day":[148,172],"29,":[149],"i.e.":[150],"last":[155],"dose,":[157],"some":[166],"50%":[167],"35,":[173],"had":[177],"returned":[178],"pretreatment":[180],"values.":[181],"prolactin,":[185],"testosterone":[186],"etc.":[187],"unchanged":[189],"Rantidine":[194],"may":[197],"therefore":[198],"used":[200],"as":[201],"acute":[208],"treatment":[209],"peptic":[211],"ulcer":[212],"disease.":[213]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
