{"id":"https://openalex.org/W2425356816","doi":null,"title":"[Decoding errors--function of the ribosomal E site].","display_name":"[Decoding errors--function of the ribosomal E site].","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2425356816","mag":"2425356816","pmid":"https://pubmed.ncbi.nlm.nih.gov/19248581"},"language":"pl","primary_location":{"id":"pmid:19248581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19248581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postepy biochemii","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109425020","display_name":"Kamilla B\u0105kowska\u2010\u017bywicka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152414","display_name":"Institute of Bioorganic Chemistry, Polish Academy of Sciences","ror":"https://ror.org/04ejdtr48","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210152414","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Kamilla Bakowska-Zywicka","raw_affiliation_strings":["Instytut Chemii Bioorganicznej PAN, Pozna\u0144. bakowska@ibch.poznan.pl","Instytut Chemii Bioorganicznej PAN, Pozna\u0144"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instytut Chemii Bioorganicznej PAN, Pozna\u0144. bakowska@ibch.poznan.pl","institution_ids":["https://openalex.org/I4210152414"]},{"raw_affiliation_string":"Instytut Chemii Bioorganicznej PAN, Pozna\u0144","institution_ids":["https://openalex.org/I4210152414"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018704491","display_name":"Marta Sikora","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Sikora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080532405","display_name":"Tomasz Twardowski","orcid":"https://orcid.org/0000-0001-9153-6561","observed_orcids":["https://orcid.org/0000-0001-9153-6561"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomasz Twardowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27836957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"54","issue":"4","first_page":"354","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribosome","display_name":"ribosome","score":0.6200000047683716},{"id":"https://openalex.org/keywords/decoding","display_name":"decoding","score":0.36000001430511475},{"id":"https://openalex.org/keywords/trna-binding-sites","display_name":"tRNA binding sites","score":0.6710000038146973},{"id":"https://openalex.org/keywords/a-site","display_name":"A-site","score":0.6179999709129333},{"id":"https://openalex.org/keywords/p-site","display_name":"P site","score":0.996999979019165},{"id":"https://openalex.org/keywords/deacylated-trna","display_name":"deacylated tRNA","score":0.8190000057220459},{"id":"https://openalex.org/keywords/translocation","display_name":"translocation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/aminoacyl-trna","display_name":"aminoacyl-tRNA","score":0.6930000185966492},{"id":"https://openalex.org/keywords/codon-recognition","display_name":"codon recognition","score":0.5559999942779541},{"id":"https://openalex.org/keywords/translation-accuracy","display_name":"translation accuracy","score":0.6669999957084656},{"id":"https://openalex.org/keywords/reading-frame","display_name":"reading frame","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.8020911812782288},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.7921805381774902},{"id":"https://openalex.org/C106774688","wikidata":"https://www.wikidata.org/wiki/Q6588997","display_name":"P-site","level":5,"score":0.636123776435852},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.598572313785553},{"id":"https://openalex.org/C96267730","wikidata":"https://www.wikidata.org/wiki/Q4647010","display_name":"A-site","level":3,"score":0.5275701284408569},{"id":"https://openalex.org/C129194359","wikidata":"https://www.wikidata.org/wiki/Q2636953","display_name":"Eukaryotic Ribosome","level":5,"score":0.5047544240951538},{"id":"https://openalex.org/C10853874","wikidata":"https://www.wikidata.org/wiki/Q180618","display_name":"Genetic code","level":3,"score":0.4947156608104706},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.4527459740638733},{"id":"https://openalex.org/C55334214","wikidata":"https://www.wikidata.org/wiki/Q416807","display_name":"Shine-Dalgarno sequence","level":5,"score":0.44618529081344604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4413357973098755},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43470290303230286},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.41132745146751404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3674708604812622},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.33516639471054077},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32593634724617004},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.12803462147712708},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11560288071632385}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012269","descriptor_name":"Ribosomal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012343","descriptor_name":"RNA, Transfer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:19248581","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19248581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postepy biochemii","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2152001964","https://openalex.org/W106498347","https://openalex.org/W3188060135","https://openalex.org/W2027630432","https://openalex.org/W32286231","https://openalex.org/W7140246804","https://openalex.org/W2016684364","https://openalex.org/W2075685878","https://openalex.org/W7009338341","https://openalex.org/W1825092957"],"abstract_inverted_index":{"In":[0,130],"the":[1,4,15,18,22,31,40,47,69,76,87,103,110,119,133,143,147],"sixties":[2],"of":[3,98,123,127,142],"last":[5,111],"(20th)":[6],"century":[7],"James":[8],"Watson":[9],"presented":[10],"a":[11,138],"two-sites":[12],"model":[13],"for":[14,21,53,140],"ribosome":[16,70],"comprising":[17],"P":[19,79,88],"site":[20,136],"peptidyl":[23],"transfer":[24],"RNA":[25],"(tRNA)":[26],"before":[27,81],"peptide-bond":[28],"formation":[29],"and":[30,78,85,89,125],"A":[32,77],"site,":[33,49],"where":[34],"decoding":[35],"takes":[36],"place":[37],"according":[38],"to":[39],"codon":[41],"exposed":[42],"there.":[43],"Twenty":[44],"years":[45],"later":[46],"E":[48,90,135],"which":[50],"was":[51,56],"specific":[52],"deacylated":[54],"tRNA":[55,62],"detected.":[57],"However,":[58],"despite":[59],"having":[60,99],"three":[61],"binding":[63],"sites,":[64],"only":[65],"two":[66,100],"tRNAs":[67,101],"occupy":[68],"simultanously":[71],"during":[72,109],"protein":[73],"synthesis:":[74],"at":[75,86],"sites":[80,91],"translocation":[82,93],"(PRE":[83],"state)":[84],"after":[92],"(POST":[94],"state).":[95],"The":[96],"importance":[97],"in":[102,146],"POST":[104],"state":[105],"has":[106,115],"been":[107,116],"revealed":[108],"25":[112],"years.":[113],"It":[114],"shown,":[117],"that":[118],"E-tRNA":[120],"prevents":[121],"misincorporation":[122],"aminoacids":[124],"loss":[126],"reading":[128],"frame.":[129],"other":[131],"words,":[132],"ribosomal":[134],"is":[137],"guard":[139],"accuracy":[141],"polypeptide":[144],"synthesized":[145],"ribosomes.":[148]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}