{"id":"https://openalex.org/W2425356080","doi":null,"title":"[A novel anticancer drug delivery system -DAC-70/CDDP].","display_name":"[A novel anticancer drug delivery system -DAC-70/CDDP].","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W2425356080","mag":"2425356080","pmid":"https://pubmed.ncbi.nlm.nih.gov/18219931"},"language":"ja","primary_location":{"id":"pmid:18219931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18219931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030117102","display_name":"Akio Sugitachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180680657","display_name":"Iwate Medical University","ror":"https://ror.org/04cybtr86","country_code":"JP","type":"education","lineage":["https://openalex.org/I180680657"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akio Sugitachi","raw_affiliation_strings":["Dept. of Surgery, Iwate Medical University","Department of Surgery, Iwate Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgery, Iwate Medical University","institution_ids":["https://openalex.org/I180680657"]},{"raw_affiliation_string":"Department of Surgery, Iwate Medical University","institution_ids":["https://openalex.org/I180680657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084820122","display_name":"Koki Otsuka","orcid":"https://orcid.org/0000-0002-5866-0461","observed_orcids":["https://orcid.org/0000-0002-5866-0461"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koki Otsuka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058261300","display_name":"Kentaro Fujisawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kentaro Fujisawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109594903","display_name":"Tetsuya Itabashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tetsuya Itabashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024937729","display_name":"Yuji Akiyama","orcid":"https://orcid.org/0000-0001-5658-7419","observed_orcids":["https://orcid.org/0000-0001-5658-7419"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuji Akiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112146206","display_name":"Akira Sasaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akira Sasaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055321515","display_name":"Kenichiro Ikeda","orcid":"https://orcid.org/0000-0002-3174-8738","observed_orcids":["https://orcid.org/0000-0002-3174-8738"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenichiro Ikeda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Yasuo Yoshida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuo Yoshida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021927640","display_name":"Yoshimori Takamori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshimori Takamori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111770205","display_name":"Seiji Kurozumi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seiji Kurozumi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018355890","display_name":"Takatoshi Mori","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takatoshi Mori","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071187535","display_name":"Go Wakabayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Go Wakabayashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36196178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"12","first_page":"2159","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deacetylated-chitin","display_name":"deacetylated chitin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9240000247955322},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":1.0},{"id":"https://openalex.org/keywords/colonic-mucosa","display_name":"colonic mucosa","score":0.6499999761581421},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.9409999847412109},{"id":"https://openalex.org/keywords/chitin-degradation","display_name":"chitin degradation","score":0.6079999804496765},{"id":"https://openalex.org/keywords/local-chemotherapy","display_name":"local chemotherapy","score":0.5360000133514404},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C2781088250","wikidata":"https://www.wikidata.org/wiki/Q161219","display_name":"Chitin","level":3,"score":0.824996829032898},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7730487585067749},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.7082375884056091},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.7000718116760254},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.6998294591903687},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6232028603553772},{"id":"https://openalex.org/C68928338","wikidata":"https://www.wikidata.org/wiki/Q131790","display_name":"Adhesive","level":3,"score":0.5963295698165894},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5685632228851318},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.49895215034484863},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.48981019854545593},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4628647267818451},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.43032315373420715},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.39859023690223694},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3912033438682556},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17116358876228333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15986445546150208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13147783279418945},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.11705929040908813},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06454095244407654},{"id":"https://openalex.org/C2779227376","wikidata":"https://www.wikidata.org/wiki/Q6505497","display_name":"Layer (electronics)","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002686","descriptor_name":"Chitin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:18219931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18219931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2408962614","https://openalex.org/W56516138","https://openalex.org/W2411607031","https://openalex.org/W2009149797","https://openalex.org/W2740567088","https://openalex.org/W3096849847","https://openalex.org/W4311577550","https://openalex.org/W2057910163","https://openalex.org/W2006530937","https://openalex.org/W4377140395"],"abstract_inverted_index":{"We":[0,82],"devised":[1],"a":[2,34,47,65],"muco-adhesive":[3,49],"anticancer":[4],"drug":[5,39,70],"delivery":[6],"system":[7,24,45,63,74,111],"using":[8],"70%":[9],"deacetylated":[10],"chitin":[11,100,105],"(DAC-70)":[12],"and":[13,16,25,33,90,101,106],"cisplatin":[14],"(CDDP)":[15],"5-fluorouracil":[17],"(5-FU).":[18],"The":[19,61,109],"adhesive":[20],"force":[21,50],"between":[22,103],"the":[23,69,72,80,85,99,104],"human":[26],"colonic":[27],"mucosa":[28],"was":[29,40],"measured":[30],"ex":[31],"vivo,":[32],"release":[35,67,86],"profile":[36,87],"of":[37,57,68,79,88,98],"each":[38,107],"examined":[41],"in":[42,116],"vitro.":[43],"Each":[44],"demonstrated":[46],"stronger":[48],"at":[51],"37":[52],"degrees":[53,59],"C":[54],"than":[55],"that":[56,84],"25":[58],"C.":[60],"CDDP-loaded":[62],"showed":[64],"sustained":[66],"while":[71],"5-FU-loaded":[73],"exhibited":[75],"an":[76],"initial":[77],"bursting":[78],"agent.":[81],"presume":[83],"CDDP":[89],"5-FU":[91],"is":[92],"closely":[93],"related":[94],"to":[95],"both":[96],"degradability":[97],"interactions":[102],"drug.":[108],"DAC-70/CDDP":[110],"would":[112],"be":[113],"clinically":[114],"promising":[115],"loco-regional":[117],"cancer":[118],"chemotherapy.":[119]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}