{"id":"https://openalex.org/W2425248381","doi":"https://doi.org/10.1016/s0022-5347(17)44476-4","title":"A Dose Response Analysis of Purpurin Derivatives Used as Photosensitizers for the Photodynamic Treatment of Transplantable Fanft Induced Urothelial Tumors","display_name":"A Dose Response Analysis of Purpurin Derivatives Used as Photosensitizers for the Photodynamic Treatment of Transplantable Fanft Induced Urothelial Tumors","publication_year":1987,"publication_date":"1987-06-01","ids":{"openalex":"https://openalex.org/W2425248381","doi":"https://doi.org/10.1016/s0022-5347(17)44476-4","mag":"2425248381","pmid":"https://pubmed.ncbi.nlm.nih.gov/3586170"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(17)44476-4","doi":"https://doi.org/10.1016/s0022-5347(17)44476-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)44476-4","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081142231","display_name":"Steven H. Selman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven H. Selman","raw_affiliation_strings":["From the Departments of Surgery (Urology) and Biochemistry, Medical College of Ohio, the Department of Chemistry, University of Toledo, and St. Vincent Medical Center, Toledo, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (Urology) and Biochemistry, Medical College of Ohio, the Department of Chemistry, University of Toledo, and St. Vincent Medical Center, Toledo, Ohio","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015789340","display_name":"Greta M. Garbo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greta M. Garbo","raw_affiliation_strings":["From the Departments of Surgery (Urology) and Biochemistry, Medical College of Ohio, the Department of Chemistry, University of Toledo, and St. Vincent Medical Center, Toledo, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (Urology) and Biochemistry, Medical College of Ohio, the Department of Chemistry, University of Toledo, and St. Vincent Medical Center, Toledo, Ohio","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111452586","display_name":"Rick W. Keck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rick W. Keck","raw_affiliation_strings":["From the Departments of Surgery (Urology) and Biochemistry, Medical College of Ohio, the Department of Chemistry, University of Toledo, and St. Vincent Medical Center, Toledo, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (Urology) and Biochemistry, Medical College of Ohio, the Department of Chemistry, University of Toledo, and St. Vincent Medical Center, Toledo, Ohio","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011048863","display_name":"Martha Kreimer\u2010Birnbaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martha Kreimer-Birnbaum","raw_affiliation_strings":["From the Departments of Surgery (Urology) and Biochemistry, Medical College of Ohio, the Department of Chemistry, University of Toledo, and St. Vincent Medical Center, Toledo, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (Urology) and Biochemistry, Medical College of Ohio, the Department of Chemistry, University of Toledo, and St. Vincent Medical Center, Toledo, Ohio","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"last","author":{"id":null,"display_name":"Alan R. Morgan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan R. Morgan","raw_affiliation_strings":["From the Departments of Surgery (Urology) and Biochemistry, Medical College of Ohio, the Department of Chemistry, University of Toledo, and St. Vincent Medical Center, Toledo, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Surgery (Urology) and Biochemistry, Medical College of Ohio, the Department of Chemistry, University of Toledo, and St. Vincent Medical Center, Toledo, Ohio","institution_ids":["https://openalex.org/I90871651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I90871651"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":5.2071,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.95323308,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"137","issue":"6","first_page":"1255","last_page":"1257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photosensitizers","display_name":"photosensitizers","score":0.9919999837875366},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/urothelial-tumors","display_name":"urothelial tumors","score":0.8960000276565552},{"id":"https://openalex.org/keywords/transplantable-tumors","display_name":"transplantable tumors","score":0.7990000247955322},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.6449999809265137},{"id":"https://openalex.org/keywords/red-light","display_name":"red light","score":0.7239999771118164},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.8999999761581421},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.8590373992919922},{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.5370750427246094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48516494035720825},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37350597977638245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29479479789733887},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.19802144169807434},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07788226008415222}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005200","descriptor_name":"FANFT","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5347(17)44476-4","doi":"https://doi.org/10.1016/s0022-5347(17)44476-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)44476-4","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:3586170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3586170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2025361833","display_name":null,"funder_award_id":"R01 CA 43006-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2147949871","display_name":null,"funder_award_id":"R23CA 38754-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3506358336","display_name":"NEW PHOTOSENSITIZERS FOR PHOTODYNAMIC CANCER THERAPY","funder_award_id":"5r01ca043006-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G590118667","display_name":"THE EFFECT OF PHOTORADIATION THERAPY ON BLOOD FLOW","funder_award_id":"5r23ca038754-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W51227804","https://openalex.org/W1570836843","https://openalex.org/W1968996774","https://openalex.org/W2165389111","https://openalex.org/W2221514827","https://openalex.org/W2283111676","https://openalex.org/W2413917854","https://openalex.org/W2424964546","https://openalex.org/W2425036212"],"related_works":["https://openalex.org/W2165389111","https://openalex.org/W2010693335","https://openalex.org/W1553599008","https://openalex.org/W2409471203","https://openalex.org/W2027055150","https://openalex.org/W2013077770","https://openalex.org/W2007263846","https://openalex.org/W2024721268","https://openalex.org/W335773040","https://openalex.org/W2045118588"],"abstract_inverted_index":{"Rats":[0],"engrafted":[1],"with":[2,12,56,103],"transplantable":[3],"N-[4-(5-nitro-2-furyl)-2-thiazolyl]":[4],"formamide":[5],"(FANFT)":[6],"induced":[7,82],"urothelial":[8],"tumors":[9,27],"were":[10,28],"treated":[11],"purpurin":[13],"derivatives":[14],"and":[15,25,34,43,52,79,99],"red":[16],"light":[17,70,80],"(greater":[18],"than":[19,63,88],"590":[20],"nm.,":[21],"360":[22],"joules/cm.2).":[23],"Treated":[24],"control":[26],"harvested":[29],"12":[30],"days":[31],"after":[32],"treatment":[33],"dry":[35],"weights":[36],"compared.":[37],"At":[38,73],"doses":[39],"of":[40,107],"5.0":[41],"micrograms./gm.":[42,45,75],"2.5":[44],"body":[46,76],"weight,":[47,77],"the":[48],"purpurins":[49],"designated":[50],"NT1":[51,78],"NT2,":[53],"when":[54,67],"combined":[55],"light,":[57],"caused":[58],"statistically":[59],"significant":[60,83],"(p":[61,86],"less":[62,87],"0.02)":[64],"tumor":[65,84],"regression":[66,85],"compared":[68],"to":[69,110],"shielded":[71],"controls.":[72],"1.0":[74],"also":[81],"0.02).":[89],"Purpurins,":[90],"which":[91],"have":[92,111],"strong":[93],"absorption":[94],"bands":[95],"above":[96],"650":[97],"nm.":[98],"can":[100],"be":[101],"synthesized":[102],"a":[104],"high":[105],"degree":[106],"purity,":[108],"appear":[109],"potential":[112],"as":[113],"photosensitizers":[114],"for":[115],"photodynamic":[116],"therapy.":[117]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}