{"id":"https://openalex.org/W2425194846","doi":null,"title":"Urinary TNF-binding protein (TNF soluble receptor) protects mice against the lethal effect of TNF and endotoxic shock.","display_name":"Urinary TNF-binding protein (TNF soluble receptor) protects mice against the lethal effect of TNF and endotoxic shock.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2425194846","mag":"2425194846","pmid":"https://pubmed.ncbi.nlm.nih.gov/8387827"},"language":"en","primary_location":{"id":"pmid:8387827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8387827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European cytokine network","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107947729","display_name":"Riccardo Bertini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19630809","display_name":"Mario Negri Institute for Pharmacological Research","ror":"https://ror.org/05aspc753","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I19630809","https://openalex.org/I4210110338","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Bertini","raw_affiliation_strings":["Mario Negri Institute for Pharmacological Research, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mario Negri Institute for Pharmacological Research, Milan, Italy","institution_ids":["https://openalex.org/I19630809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073979340","display_name":"Ren\u00e9 Delgado","orcid":"https://orcid.org/0000-0001-7051-7871","observed_orcids":["https://orcid.org/0000-0001-7051-7871"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Delgado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056241510","display_name":"Raffaella Faggioni","orcid":"https://orcid.org/0009-0007-1732-9311","observed_orcids":["https://orcid.org/0009-0007-1732-9311"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Faggioni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007627882","display_name":"Marie-Paule Gascon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M P Gascon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109043780","display_name":"A. Ythier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Ythier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049977155","display_name":"Pietro Ghezzi","orcid":"https://orcid.org/0000-0003-0911-8358","observed_orcids":["https://orcid.org/0000-0003-0911-8358"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Ghezzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0858,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.93650204,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"4","issue":"1","first_page":"39","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.6934000253677368,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.6934000253677368,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.20589999854564667,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.05999999865889549,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soluble-tnf-receptors","display_name":"soluble TNF receptors","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/endotoxic-shock","display_name":"endotoxic shock","score":0.9319999814033508},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.9100000262260437},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9319999814033508},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/protective-effect","display_name":"protective effect","score":0.5139999985694885},{"id":"https://openalex.org/keywords/dose-dependent-protection","display_name":"dose-dependent protection","score":0.546999990940094},{"id":"https://openalex.org/keywords/timing-of-drug-administration","display_name":"timing of drug administration","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.8806884288787842},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.6964988708496094},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.6200735569000244},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5091254115104675},{"id":"https://openalex.org/C199677211","wikidata":"https://www.wikidata.org/wiki/Q24780964","display_name":"Cold-shock domain","level":4,"score":0.5033499598503113},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.49026015400886536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4873557984828949},{"id":"https://openalex.org/C2910236225","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Endotoxic shock","level":3,"score":0.4868287444114685},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4864480197429657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46670839190483093},{"id":"https://openalex.org/C2777928079","wikidata":"https://www.wikidata.org/wiki/Q2677027","display_name":"Rat\u00f3n","level":2,"score":0.4469986855983734},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.39334020018577576},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39204174280166626},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.374978244304657},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2973971962928772},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1022685170173645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000315","descriptor_name":"Adrenalectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8387827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8387827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European cytokine network","raw_type":"Journal Article"},{"id":"pmh:oai:ora.uniurb.it:11576/2713681","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11576/2713681","pdf_url":null,"source":{"id":"https://openalex.org/S4377196377","display_name":"CINECA IRIS Institutional Research information system (University of Urbino)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I190397597","host_organization_name":"University of Urbino","host_organization_lineage":["https://openalex.org/I190397597"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2425194846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8387827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2089369357","https://openalex.org/W1593673702","https://openalex.org/W1893558770","https://openalex.org/W2022522156","https://openalex.org/W2416945871","https://openalex.org/W2091806028","https://openalex.org/W1481812944","https://openalex.org/W2351420185","https://openalex.org/W2406792781","https://openalex.org/W2015469433"],"abstract_inverted_index":{"We":[0],"tested":[1],"the":[2,10,93,111],"effect":[3,12,52,64],"of":[4,13,53,95,101,113],"urinary":[5],"TNF-binding":[6],"protein":[7],"(uTBP)":[8],"on":[9],"toxic":[11],"TNF":[14],"(0.5":[15],"micrograms/mouse,":[16,43],"i.v.)":[17,44],"in":[18,110],"adrenalectomized":[19],"mice":[20,96],"sensitized":[21],"with":[22,48],"IL-1":[23],"to":[24,27,38,72],"increase":[25],"susceptibility":[26],"TNF.":[28,49,76,89],"In":[29],"this":[30],"experimental":[31],"model,":[32],"mortality":[33],"was":[34,45,55,67,79,84],"67%,":[35],"but":[36],"decreased":[37],"13%":[39],"when":[40,65,82],"uTBP":[41,54,66,83],"(250":[42],"administered":[46,68],"simultaneously":[47],"The":[50],"protective":[51,63],"dose-dependent,":[56],"and":[57],"time":[58],"course":[59],"experiments":[60],"indicated":[61],"a":[62,98],"before":[69],"or":[70,116],"up":[71],"one":[73],"hour":[74],"after":[75,88,97],"Some":[77],"protection":[78],"also":[80],"obtained":[81],"given":[85],"three":[86],"hours":[87],"Urinary":[90],"TBP":[91],"improved":[92],"survival":[94],"lethal":[99],"dose":[100],"LPS":[102],"(1.2":[103],"mg/mouse,":[104],"i.p.),":[105],"suggesting":[106],"its":[107],"possible":[108],"efficacy":[109],"therapy":[112],"septic":[114],"shock":[115],"other":[117],"TNF-mediated":[118],"pathologies.":[119]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
