{"id":"https://openalex.org/W2425171550","doi":null,"title":"Over-utilization of the J delta 3 gene-segment in Crohn's disease.","display_name":"Over-utilization of the J delta 3 gene-segment in Crohn's disease.","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2425171550","mag":"2425171550","pmid":"https://pubmed.ncbi.nlm.nih.gov/10332632"},"language":"en","primary_location":{"id":"pmid:10332632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10332632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical & laboratory immunology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001962127","display_name":"Landau Sb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S B Landau","raw_affiliation_strings":["Division of Gastroenterology, University of Vermont, Burlington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology, University of Vermont, Burlington, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115590474","display_name":"Probert Cs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C S Probert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064231298","display_name":"C A Stevens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C A Stevens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113550740","display_name":"Steve Balk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S P Balk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018704825","display_name":"RS Blumberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R S Blumberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.28238426,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"48","issue":"1","first_page":"33","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/t-cell-receptor-gene-rearrangement","display_name":"T-cell receptor gene rearrangement","score":0.7450000047683716},{"id":"https://openalex.org/keywords/clonality","display_name":"clonality","score":0.671999990940094},{"id":"https://openalex.org/keywords/intestinal-intraepithelial-lymphocytes","display_name":"intestinal intraepithelial lymphocytes","score":0.9169999957084656},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/lymphocytic-colitis","display_name":"lymphocytic colitis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/diverticulitis","display_name":"diverticulitis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/t-cell-expansion","display_name":"T cell expansion","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.7870038747787476},{"id":"https://openalex.org/C5072461","wikidata":"https://www.wikidata.org/wiki/Q49506","display_name":"Delta","level":2,"score":0.7564940452575684},{"id":"https://openalex.org/C152605822","wikidata":"https://www.wikidata.org/wiki/Q17100626","display_name":"Intraepithelial lymphocyte","level":3,"score":0.705303966999054},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6150135397911072},{"id":"https://openalex.org/C2778993397","wikidata":"https://www.wikidata.org/wiki/Q3077796","display_name":"Gamma delta T cell","level":5,"score":0.6042290329933167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5220189690589905},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4974863827228546},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48926541209220886},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46243107318878174},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.4380030930042267},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.39652085304260254},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21222835779190063},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.20766285061836243},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.11879235506057739},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004238","descriptor_name":"Diverticulitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004238","descriptor_name":"Diverticulitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016692","descriptor_name":"Receptors, Antigen, T-Cell, gamma-delta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016692","descriptor_name":"Receptors, Antigen, T-Cell, gamma-delta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10332632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10332632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical & laboratory immunology","raw_type":"Journal Article"},{"id":"mag:2425171550","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10332632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7330644106","display_name":"FUNCTION OF HUMAN INTESTINAL INTRAEPITHELIAL LYMPHOCYTES","funder_award_id":"5r01ai033911-08","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2071641240","https://openalex.org/W1941705385","https://openalex.org/W353646662","https://openalex.org/W1988397886","https://openalex.org/W2114626144","https://openalex.org/W2030451621","https://openalex.org/W1990528332","https://openalex.org/W1967606175","https://openalex.org/W2338309055","https://openalex.org/W1524980886"],"abstract_inverted_index":{"A":[0],"majority":[1],"of":[2,23,61,72,86,107,164,177,208,230],"normal":[3,24,122],"human":[4],"intestinal":[5,65],"intraepithelial":[6],"lymphocytes":[7,53],"(iIEL)":[8],"are":[9,19,27,47],"CD8+,":[10],"express":[11,30],"the":[12,31,108,148,162,178,195,228],"alpha":[13],"beta-T":[14],"cell":[15,80],"receptor":[16],"(TCR)":[17],"and":[18,34,42,82,90,116,142,152],"oligoclonal.":[20],"The":[21,57,70],"remainder":[22],"iIELs,":[25],"which":[26,46],"also":[28],"oligoclonal,":[29],"gamma":[32,62,78,165,210],"delta-TCR":[33],"preferentially":[35],"utilize":[36],"variable":[37],"regions":[38],"(V":[39,54],"delta":[40,44,55,88,92,150,154,185,197,201,215],"1":[41,89,151,198],"V":[43,87,91,149,153,196,200],"3)":[45],"different":[48],"from":[49],"adult":[50],"peripheral":[51],"blood":[52],"2).":[56],"junctional":[58,83],"region":[59,84],"usage":[60,85],"delta-TCRs":[63],"in":[64,95,99,121,205],"diseases":[66,106],"is":[67],"largely":[68],"unknown.":[69],"aim":[71],"this":[73],"study":[74],"was":[75,192],"to":[76,101],"examine":[77],"delta-T":[79,166,211],"clonality":[81],"3":[93,155,202,216],"transcripts":[94,156,182],"Crohn's":[96],"Disease":[97],"(CD)":[98],"comparison":[100],"several":[102],"other":[103],"chronic":[104],"inflammatory":[105,125,180],"colon":[109],"by":[110],"polymerase":[111],"chain":[112],"reaction":[113],"amplification,":[114],"cloning":[115],"sequencing.":[117],"As":[118],"previously":[119],"observed":[120,193],"subjects,":[123],"all":[124],"cases":[126],"examined,":[127],"including":[128],"CD":[129,173],"(n":[130,135,139,145],"=":[131,136,140,146],"3),":[132],"ulcerative":[133],"colitis":[134,144],"1),":[137,147],"diverticulitis":[138],"1)":[141],"lymphocytic":[143],"contained":[157],"reiterated":[158],"sequences":[159],"consistent":[160],"with":[161],"expansion":[163,229],"cells":[167,212,232],"expressing":[168,213,233],"these":[169,234],"receptors.":[170,235],"In":[171],"2/3":[172],"cases,":[174,181],"but":[175],"none":[176],"non-CD":[179],"containing":[183],"J":[184,190,214],"3,":[186],"a":[187,206,221],"rarely":[188],"used":[189],"delta,":[191],"among":[194],"and/or":[199],"transcripts.":[203],"Thus,":[204],"subset":[207],"CD,":[209],"may":[217],"be":[218],"expanded":[219],"implicating":[220],"role":[222],"for":[223],"unique":[224],"ligands":[225],"that":[226],"drive":[227],"T":[231]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}