{"id":"https://openalex.org/W2425161948","doi":null,"title":"THE EFFECTS OF PARTIAL BILATERAL LESIONING OF SUBSTANTIA NIGRA IN A GENETIC ABSENCE EPILEPSY RAT MODEL","display_name":"THE EFFECTS OF PARTIAL BILATERAL LESIONING OF SUBSTANTIA NIGRA IN A GENETIC ABSENCE EPILEPSY RAT MODEL","publication_year":2016,"publication_date":"2016-12-03","ids":{"openalex":"https://openalex.org/W2425161948","mag":"2425161948"},"language":"en","primary_location":{"id":"pmh:oai:dergipark.org.tr:article/272100","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/tr/pub/marumj/issue/25800/272100","pdf_url":"https://dergipark.org.tr/tr/pub/marumj/issue/25800/272100","source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dergipark.org.tr/tr/pub/marumj/issue/25800/272100","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060360353","display_name":"Zafer G\u00f6ren","orcid":"https://orcid.org/0000-0002-5537-7396","observed_orcids":["https://orcid.org/0000-0002-5537-7396"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zafer G\u00f6ren","raw_affiliation_strings":["Department of Pharmacology and Clinical Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010017243","display_name":"Rezzan Gulhan Aker","orcid":"https://orcid.org/0000-0002-1519-3170","observed_orcids":["https://orcid.org/0000-0002-1519-3170"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Rezzan Aker","raw_affiliation_strings":["Department of Pharmacology and Clinical Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-1519-3170","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051998462","display_name":"Filiz Onat","orcid":"https://orcid.org/0000-0003-0680-4782","observed_orcids":["https://orcid.org/0000-0003-0680-4782"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Filiz Onat","raw_affiliation_strings":["Department of Pharmacology and Clinical Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-0680-4782","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111529933","display_name":"Aydan Erg\u00fcn \u00d6zkaynak\u00e7i","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Aydan Erg\u00fcn","raw_affiliation_strings":["Department of Pharmacology and Clinical Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74897591"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06364231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substantia-nigra-pars-reticulata","display_name":"substantia nigra pars reticulata","score":0.9700000286102295},{"id":"https://openalex.org/keywords/genetic-absence-epilepsy-rats-from-strasbourg","display_name":"GAERS","score":0.8479999899864197},{"id":"https://openalex.org/keywords/absence-seizures","display_name":"absence seizures","score":0.7440000176429749},{"id":"https://openalex.org/keywords/ventrolateral-thalamic-nucleus","display_name":"ventrolateral thalamic nucleus","score":0.8899999856948853},{"id":"https://openalex.org/keywords/gaba-release","display_name":"GABA release","score":0.8579999804496765},{"id":"https://openalex.org/keywords/spike-and-wave-discharges","display_name":"spike-wave discharges","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tonic-inhibition","display_name":"tonic inhibition","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.9359520673751831},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7230662107467651},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5816017985343933},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.46713781356811523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3583011031150818},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30422553420066833},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.1407921314239502},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07960164546966553},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05566394329071045},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.054745107889175415}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dergipark.org.tr:article/272100","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/tr/pub/marumj/issue/25800/272100","pdf_url":"https://dergipark.org.tr/tr/pub/marumj/issue/25800/272100","source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2425161948","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/tr/pub/marumj/issue/25800/272100","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DergiPark (Istanbul University)","raw_type":null},{"id":"pmh:oai:dergipark.gov.tr:article/272100","doi":null,"is_oa":false,"landing_page_url":"http://dergipark.gov.tr/marumj/issue/25800/272100","pdf_url":null,"source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\\n Volume: 15, Issue: 2\\n 79-85\\n \\n","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:dergipark.org.tr:article/272100","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/tr/pub/marumj/issue/25800/272100","pdf_url":"https://dergipark.org.tr/tr/pub/marumj/issue/25800/272100","source":{"id":"https://openalex.org/S4306401840","display_name":"DergiPark (Istanbul University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67581229","host_organization_name":"Istanbul University","host_organization_lineage":["https://openalex.org/I67581229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5799999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2804777659","display_name":"Genetik absans epileptik s\u0131\u00e7an modelinde substansiya nigra' n\u0131n rol\u00fc","funder_award_id":"SBAG-AYD-179","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2425161948.pdf","grobid_xml":"https://content.openalex.org/works/W2425161948.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1571175443","https://openalex.org/W1989100070","https://openalex.org/W2015743538","https://openalex.org/W2022907828","https://openalex.org/W2031170958","https://openalex.org/W2036859913","https://openalex.org/W2064272490","https://openalex.org/W2067994713","https://openalex.org/W2119709014","https://openalex.org/W2163815564","https://openalex.org/W2444240377"],"related_works":["https://openalex.org/W6990803521","https://openalex.org/W7057148519","https://openalex.org/W3095758484","https://openalex.org/W2138921841","https://openalex.org/W2081325370","https://openalex.org/W2035401777","https://openalex.org/W2084922577","https://openalex.org/W2566971922","https://openalex.org/W4415824014","https://openalex.org/W1571175443"],"abstract_inverted_index":{"Objective:":[0],"\"Genetic":[1],"Absence":[2,184],"Epilepsy":[3],"Rats":[4,176],"fromStrasbourg\"":[5],"(GAERS),":[6],"an":[7,12,39,164],"inbred":[8],"Wistar":[9],"strain,serve":[10],"as":[11,38,159],"experimental":[13],"venue.":[14],"These":[15,141],"ratsgenerate":[16],"spontaneous":[17],"spike-and-wavedischarges":[18],"(SWD)":[19],"and":[20,71,102,115,131,153],"have":[21],"increased":[22],"yaminobutyricacid":[23],"(GABA)":[24],"levels":[25,92],"in":[26,42,74,93,100,113,118,138,151,170],"theventrolateral":[27],"thalamus":[28],"(VLT).":[29],"Recently,substantia":[30],"nigra":[31],"pars":[32],"reticulata":[33],"(SNpr)":[34],"wasreported":[35],"to":[36,109],"act":[37],"endogeneous":[40],"inhibitorymechanism":[41],"the":[43],"generation,":[44],"onset":[45],"andmaintenance":[46],"of":[47,50,53,76,82,133,188],"various":[48],"types":[49],"seizures.":[51],"Thepresence":[52],"tonic":[54,149],"control":[55,150,187],"exerted":[56],"by":[57,85],"SNpr":[58,83,157],"inabsence":[59],"seizures":[60],"should":[61],"also":[62,136],"be":[63,110],"tested":[64],"inGAERS.Methods:":[65],"In":[66],"this":[67],"current":[68],"study,":[69],"GABA":[70,91,179],"Lglutamicacid":[72],"release":[73],"VLT":[75,94],"GAERS":[77,152,173],"withpartial":[78],"bilateral":[79],"electrolytic":[80],"lesions":[81],"wasevaluated":[84],"using":[86],"microdialysis":[87],"technique":[88],"withfluorescent":[89],"detection.Results:":[90],"were":[95,135],"0.12\u00b10.04":[96],"pMand":[97],"0.24\u00b10.08":[98],"pM":[99,112,117],"sham-lesioned":[101],"SNprlesionedGAERS,":[103],"respectively.":[104],"L-glutamic":[105],"acidlevel":[106],"was":[107],"found":[108],"0.415\u00b10.150":[111],"shamlesionedgroup":[114],"0.324\u00b10.094":[116],"SNprlesionedGAERS.":[119],"Statistical":[120],"analysis":[121],"revealed":[122],"nosignificant":[123],"difference":[124],"between":[125],"sham-lesionedand":[126],"SNpr-lesioned":[127],"rats.":[128],"The":[129],"number":[130],"theduration":[132],"SWD":[134],"similar":[137],"two":[139],"groups.Conclusion:":[140],"findings":[142],"show":[143],"that":[144,155,162],"SNprdoes":[145],"not":[146],"exert":[147],"a":[148,160],"weassume":[154],"intact":[156],"acts":[158],"site":[161],"mayexert":[163],"inhibition":[165],"on":[166],"target":[167],"structures":[168],"whenactivated":[169],"GAERS.Key":[171],"Words:":[172],"(Genetic":[174],"AbsenceEpilepsy":[175],"from":[177],"Strasbourg),":[178],"(yaminobutyricacid),":[180],"Substantia":[181],"nigra,Ventrolateral":[182],"thalamus,":[183],"epilepsy,Microdialysis,":[185],"Nigral":[186],"epilepsy.":[189]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
