{"id":"https://openalex.org/W242516078","doi":null,"title":"Gastroprotection and control of food intake by leptin. Comparison with cholecystokinin and prostaglandins.","display_name":"Gastroprotection and control of food intake by leptin. Comparison with cholecystokinin and prostaglandins.","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W242516078","mag":"242516078","pmid":"https://pubmed.ncbi.nlm.nih.gov/10210153"},"language":"en","primary_location":{"id":"pmid:10210153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10210153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111791462","display_name":"P C Konturek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P C Konturek","raw_affiliation_strings":["Department of Medicine I, University of Erlangen-Nuremberg, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine I, University of Erlangen-Nuremberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109936280","display_name":"Stanislaw Jan Konturek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S J Konturek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026040870","display_name":"Tomasz Brzozowski","orcid":"https://orcid.org/0000-0002-5805-0065","observed_orcids":["https://orcid.org/0000-0002-5805-0065"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Brzozowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108523079","display_name":"E.G. Hahn","orcid":"https://orcid.org/0009-0007-1301-1648","observed_orcids":["https://orcid.org/0009-0007-1301-1648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E G Hahn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8888,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.68718851,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"50","issue":"1","first_page":"39","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.996999979019165},{"id":"https://openalex.org/keywords/cholecystokinin","display_name":"cholecystokinin","score":0.9589999914169312},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.984000027179718},{"id":"https://openalex.org/keywords/gastroprotective-effect","display_name":"gastroprotection","score":0.9110000133514404},{"id":"https://openalex.org/keywords/food-intake-regulation","display_name":"food intake regulation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/ethanol-induced-gastric-lesions","display_name":"ethanol-induced gastric injury","score":0.824999988079071},{"id":"https://openalex.org/keywords/gastric-blood-flow","display_name":"gastric blood flow","score":0.8939999938011169},{"id":"https://openalex.org/keywords/gastric-mucosa","display_name":"gastric mucosa","score":0.7820000052452087},{"id":"https://openalex.org/keywords/gastric-epithelium","display_name":"gastric epithelium","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cck-8","display_name":"CCK-8","score":0.7490000128746033},{"id":"https://openalex.org/keywords/plasma-leptin","display_name":"plasma leptin","score":0.6309999823570251},{"id":"https://openalex.org/keywords/ob-gene","display_name":"ob gene","score":0.5519999861717224},{"id":"https://openalex.org/keywords/gastric-mucosal-injury","display_name":"gastric mucosal injury","score":0.414000004529953},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.9447041749954224},{"id":"https://openalex.org/C2777593968","wikidata":"https://www.wikidata.org/wiki/Q60315441","display_name":"Cholecystokinin","level":3,"score":0.6916977167129517},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6714627742767334},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6614205241203308},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5963596701622009},{"id":"https://openalex.org/C2781443798","wikidata":"https://www.wikidata.org/wiki/Q383249","display_name":"Gastric mucosa","level":3,"score":0.5156949162483215},{"id":"https://openalex.org/C14372207","wikidata":"https://www.wikidata.org/wiki/Q7072306","display_name":"Leptin receptor","level":4,"score":0.45557042956352234},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44568386673927307},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.428996205329895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26655393838882446},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.08218458294868469}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002766","descriptor_name":"Cholecystokinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004064","descriptor_name":"Digestive System","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D004064","descriptor_name":"Digestive System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005767","descriptor_name":"Gastrointestinal Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10210153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10210153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Comparative Study"},{"id":"mag:242516078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10210153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2060124672","https://openalex.org/W2091556962","https://openalex.org/W2143135468","https://openalex.org/W2086180221","https://openalex.org/W772237255","https://openalex.org/W1551216731","https://openalex.org/W31768796","https://openalex.org/W1984451937","https://openalex.org/W2959273806","https://openalex.org/W2065981973"],"abstract_inverted_index":{"Circulating":[0],"peptide":[1],"leptin":[2,31,35,44,61,86,143,251,350,357,366],"which":[3],"is":[4,11],"the":[5,8,18,55,79,83,90,93,137,164,185,205,213,235,247,287,318,321,332,348,373,399,406,423],"product":[6],"of":[7,20,58,85,95,119,124,139,142,160,166,169,182,187,190,207,215,230,249,263,307,317,320,409,419],"ob":[9],"gene":[10],"known":[12],"to":[13,23,47,69,81,99,134,233,387],"provide":[14],"feedback":[15],"information":[16],"on":[17,89,149,174,197,212],"size":[19],"fat":[21],"stores":[22],"central":[24],"OB-receptors":[25],"that":[26,388,422],"control":[27,94],"food":[28,96,333,402],"intake.":[29],"Recently,":[30],"messenger":[32],"RNA":[33],"and":[34,43,87,92,98,130,157,179,201,203,210,241,268,277,301,310,327,341,358,381,404,412],"protein":[36],"have":[37],"been":[38,67],"detected":[39],"in":[40,108,218,260,347,363,398,401,433],"gastric":[41,60,71,112,151,153,176,199,281,370,436],"epithelium":[42],"was":[45,258,337],"found":[46],"be":[48],"released":[49],"by":[50,116,253,284,292,314,324,376,416,426,435],"CCK":[51,65,88,209,276,328,342,382,411],"into":[52],"circulation":[53],"but":[54,392],"physiological":[56],"role":[57],"this":[59],"remains":[62],"unknown.":[63],"As":[64],"has":[66],"reported":[68],"protect":[70,368],"mucosa":[72,371],"against":[73,372],"various":[74,140,167,188],"noxious":[75],"agents,":[76],"we":[77],"designed":[78],"study":[80],"determine":[82],"influence":[84,206],"gastroprotection":[91],"intake":[97,214,257,334,403],"compare":[100],"them":[101],"with":[102,110,223,271,390],"classic":[103],"gastroprotective":[104,385],"substance,":[105],"prostaglandin":[106],"E2,":[107],"rats":[109,126,264],"acute":[111],"mucosal":[113],"lesions":[114,200,282,291],"induced":[115,283],"topical":[117],"application":[118],"75%":[120,231,285,377],"ethanol.":[121,325],"Four":[122],"series":[123],"Wistar":[125],"(A,":[127],"B,":[128],"C":[129],"D)":[131,204],"were":[132,221,244,312,395,414],"used":[133],"determine;":[135],"A)":[136],"effects":[138,165,186,306,408],"doses":[141,168,189],"(0.1-10":[144,171],"microg/kg)":[145,193],"given":[146,194],"intraperitoneally":[147],"(i.p.)":[148],"ethanol-induced":[150,175,198],"lesions,":[152,177],"blood":[154,242],"flow":[155],"(GBF)":[156],"plasma":[158,180,250,349,364],"levels":[159,181,252],"immunoreactive":[161,365],"leptin;":[162,183],"B)":[163],"CCK-8":[170,309],"microg/kg":[172,300],"i.p.)":[173],"GBF":[178,202,236,322,420],"C)":[184],"PGE2":[191,211,278,311,336,391,394,413],"(12.5--100":[192],"intragastrically":[195],"(i.g.)":[196],"leptin,":[208,308,410],"liquid":[216,272],"meal":[217],"rats.":[219],"Rats":[220],"anesthetized":[222],"ether":[224],"1":[225,297],"h":[226,267],"after":[227],"i.g.":[228],"administration":[229],"ethanol":[232],"measure":[234],"using":[237],"H2-gas":[238],"clearance":[239],"technique":[240],"samples":[243],"withdrawn":[245],"for":[246],"measurement":[248],"radioimmunoassay":[254],"(RIA).":[255],"Food":[256],"assessed":[259],"separate":[261],"group":[262],"fasted":[265],"18":[266],"then":[269],"fed":[270],"caloric":[273],"meal.":[274],"Leptin,":[275],"reduced":[279,329],"dose-dependently":[280,331,369],"ethanol,":[286],"dose":[288],"reducing":[289],"these":[290,427],"50%":[293],"(ED50)":[294],"being,":[295],"respectively,":[296],"microg/kg,":[298],"5":[299],"20":[302],"microg/kg.":[303],"The":[304],"protective":[305,407],"accompanied":[313,415],"significant":[315,417],"attenuation":[316],"fall":[319],"caused":[323],"Leptin":[326,340,380],"also":[330],"while":[335],"not":[338],"effective.":[339],"resulted":[343],"a":[344],"dose-dependent":[345],"increment":[346],"levels.":[351],"We":[352],"conclude":[353],"that:":[354],"1)":[355],"exogenous":[356],"CCK,":[359],"causing":[360],"similar":[361,384],"increments":[362],"levels,":[367],"damage":[374],"provoked":[375],"ethanol;":[378],"2)":[379],"afford":[383],"activity":[386],"attained":[389],"unlike":[393],"highly":[396],"effective":[397],"reduction":[400],"3)":[405],"increase":[418],"suggesting":[421],"protection":[424],"afforded":[425],"substances":[428],"are":[429],"mediated,":[430],"at":[431],"least":[432],"part,":[434],"hyperemia.":[437]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}