{"id":"https://openalex.org/W2424784666","doi":"https://doi.org/10.1182/blood.v114.22.3433.3433","title":"Correlation Between Serum Ofatumumab Concentrations, Baseline Patient Characteristics and Clinical Outcomes in Patients with Fludarabine-Refractory Chronic Lymphocytic Leukemia (CLL) Treated with Single-Agent Ofatumumab.","display_name":"Correlation Between Serum Ofatumumab Concentrations, Baseline Patient Characteristics and Clinical Outcomes in Patients with Fludarabine-Refractory Chronic Lymphocytic Leukemia (CLL) Treated with Single-Agent Ofatumumab.","publication_year":2009,"publication_date":"2009-11-20","ids":{"openalex":"https://openalex.org/W2424784666","doi":"https://doi.org/10.1182/blood.v114.22.3433.3433","mag":"2424784666"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v114.22.3433.3433","doi":"https://doi.org/10.1182/blood.v114.22.3433.3433","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v114.22.3433.3433","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049924304","display_name":"Anders \u00d6sterborg","orcid":"https://orcid.org/0000-0001-6489-4865","observed_orcids":["https://orcid.org/0000-0001-6489-4865"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anders O\u0308sterborg","raw_affiliation_strings":["Deptartment of Hematology, Karolinska Hospital, Stockholm, Sweden,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deptartment of Hematology, Karolinska Hospital, Stockholm, Sweden,","institution_ids":["https://openalex.org/I1335113835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040502835","display_name":"Birgitte Biilmann R\u00f8nn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163256","display_name":"Genmab (Denmark)","ror":"https://ror.org/057pe1087","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210163256"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Birgitte Biilmann Ronn","raw_affiliation_strings":["Genmab, Copenhagen, Denmark,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Copenhagen, Denmark,","institution_ids":["https://openalex.org/I4210163256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023508449","display_name":"Roxanne C. Jewell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Roxanne C Jewell","raw_affiliation_strings":["GlaxoSmithKline, Research Triangle Park, NC, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline, Research Triangle Park, NC, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036828560","display_name":"Thomas J. Kipps","orcid":"https://orcid.org/0000-0002-0064-4549","observed_orcids":["https://orcid.org/0000-0002-0064-4549"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J Kipps","raw_affiliation_strings":["UCSD Moores Cancer Center, La Jolla, CA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSD Moores Cancer Center, La Jolla, CA, USA,","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054654885","display_name":"Ji\u0159\u0131\u0301 Mayer","orcid":"https://orcid.org/0000-0003-0567-9887","observed_orcids":["https://orcid.org/0000-0003-0567-9887"]},"institutions":[{"id":"https://openalex.org/I4210102302","display_name":"University Hospital Brno","ror":"https://ror.org/00qq1fp34","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210102302"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jiri Mayer","raw_affiliation_strings":["Dept of Internal Medicine/Hemato-Oncology, Faculty Hospital Brno, Brno, Czech Republic,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Internal Medicine/Hemato-Oncology, Faculty Hospital Brno, Brno, Czech Republic,","institution_ids":["https://openalex.org/I4210102302"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019866348","display_name":"Stephan Stilgenbauer","orcid":"https://orcid.org/0000-0002-6830-9296","observed_orcids":["https://orcid.org/0000-0002-6830-9296"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]},{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stephan Stilgenbauer","raw_affiliation_strings":["Department of Internal Medicine III, Universita\u0308tsklinikum Ulm, Ulm, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, Universita\u0308tsklinikum Ulm, Ulm, Germany,","institution_ids":["https://openalex.org/I196349391","https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108223317","display_name":"C. D. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334287468","display_name":"Nottingham University Hospitals NHS Trust","ror":"https://ror.org/05y3qh794","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Cathy D Williams","raw_affiliation_strings":["Centre for Clinical Haematology, Nottingham University Hospitals, Nottingham, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Clinical Haematology, Nottingham University Hospitals, Nottingham, United Kingdom,","institution_ids":["https://openalex.org/I1334287468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059959042","display_name":"Andrzej Rafal Hellmann","orcid":"https://orcid.org/0000-0002-9258-3244","observed_orcids":["https://orcid.org/0000-0002-9258-3244"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Andrzej Hellmann","raw_affiliation_strings":["Department of Hematology, Medical University of Gdansk, Gdansk, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Medical University of Gdansk, Gdansk, Poland,","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087571749","display_name":"Tadeusz Robak","orcid":"https://orcid.org/0000-0002-3411-6357","observed_orcids":["https://orcid.org/0000-0002-3411-6357"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tadeusz Robak","raw_affiliation_strings":["Department of Haematology, Medical University of Lodz, Lodz, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Medical University of Lodz, Lodz, Poland,","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013974745","display_name":"Richard R. Furman","orcid":"https://orcid.org/0000-0003-1677-7626","observed_orcids":["https://orcid.org/0000-0003-1677-7626"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard R Furman","raw_affiliation_strings":["Division of Hematology/Oncology, Weill Cornell Medical College, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Weill Cornell Medical College, New York, NY, USA,","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047631289","display_name":"Peter Hillmen","orcid":"https://orcid.org/0000-0001-5617-4403","observed_orcids":["https://orcid.org/0000-0001-5617-4403"]},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Peter Hillmen","raw_affiliation_strings":["St James' Institute of Oncology, St James' University Hospital, Leeds, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St James' Institute of Oncology, St James' University Hospital, Leeds, United Kingdom,","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088476247","display_name":"Marek Trn\u011bn\u00fd","orcid":"https://orcid.org/0000-0002-6952-6073","observed_orcids":["https://orcid.org/0000-0002-6952-6073"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Marek Trneny","raw_affiliation_strings":["First Faculty of Medicine, Charles University General Hospital, Prague, Czech Republic,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Faculty of Medicine, Charles University General Hospital, Prague, Czech Republic,","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081516283","display_name":"Martin J.S. Dyer","orcid":"https://orcid.org/0000-0002-5033-2236","observed_orcids":["https://orcid.org/0000-0002-5033-2236"]},"institutions":[{"id":"https://openalex.org/I2800281165","display_name":"Leicester Royal Infirmary","ror":"https://ror.org/03jkz2y73","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800281165","https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Martin JS Dyer","raw_affiliation_strings":["Department of Haematology, Leicester Royal Infirmary, Leicester, United Kingdom,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Leicester Royal Infirmary, Leicester, United Kingdom,","institution_ids":["https://openalex.org/I2800281165"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Swami Padmanabhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Swami Padmanabhan","raw_affiliation_strings":["Roswell Park Cancer Institute, Buffalo, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Cancer Institute, Buffalo, NY, USA,","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027293079","display_name":"Magdalena Piotrowska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Magdalena Piotrowska","raw_affiliation_strings":["Klinika Hematologii CMUJ, Krakow, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinika Hematologii CMUJ, Krakow, Poland,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102919781","display_name":"Tom\u00e1\u0161 Koz\u00e1k","orcid":"https://orcid.org/0009-0005-2446-7988","observed_orcids":["https://orcid.org/0009-0005-2446-7988"]},"institutions":[{"id":"https://openalex.org/I4210156160","display_name":"University Hospital Kralovske Vinohrady","ror":"https://ror.org/04sg4ka71","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210156160"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Tomas Kozak","raw_affiliation_strings":["Department Of Clinical Hematology, University Hospital Kralovske Vinohrady, Prague, Czech Republic,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Clinical Hematology, University Hospital Kralovske Vinohrady, Prague, Czech Republic,","institution_ids":["https://openalex.org/I4210156160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103114173","display_name":"Geoffrey W Chan","orcid":"https://orcid.org/0000-0001-6468-0103","observed_orcids":["https://orcid.org/0000-0001-6468-0103"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Geoffrey Chan","raw_affiliation_strings":["GlaxoSmithKline, Collegeville, PA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline, Collegeville, PA, USA,","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109000255","display_name":"M. Arning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Arning","raw_affiliation_strings":["GlaxoSmithKline, Collegeville, PA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline, Collegeville, PA, USA,","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068017392","display_name":"Nedjad Losic","orcid":"https://orcid.org/0009-0003-9329-5425","observed_orcids":["https://orcid.org/0009-0003-9329-5425"]},"institutions":[{"id":"https://openalex.org/I4210163256","display_name":"Genmab (Denmark)","ror":"https://ror.org/057pe1087","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210163256"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Nedjad Losic","raw_affiliation_strings":["Genmab, Copenhagen, Denmark,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Copenhagen, Denmark,","institution_ids":["https://openalex.org/I4210163256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012302432","display_name":"Randy L. Davis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Randy Davis","raw_affiliation_strings":["GlaxoSmithKline, Research Triangle Park, NC, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline, Research Triangle Park, NC, USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047591504","display_name":"Joris Wilms","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163256","display_name":"Genmab (Denmark)","ror":"https://ror.org/057pe1087","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210163256"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Joris Wilms","raw_affiliation_strings":["Genmab, Copenhagen, Denmark,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Copenhagen, Denmark,","institution_ids":["https://openalex.org/I4210163256"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Charlotte A Russell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163256","display_name":"Genmab (Denmark)","ror":"https://ror.org/057pe1087","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210163256"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Charlotte A Russell","raw_affiliation_strings":["Genmab, Copenhagen, Denmark,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Copenhagen, Denmark,","institution_ids":["https://openalex.org/I4210163256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089428686","display_name":"William G. Wierda","orcid":"https://orcid.org/0000-0002-7357-270X","observed_orcids":["https://orcid.org/0000-0002-7357-270X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William G Wierda","raw_affiliation_strings":["M.D. Anderson Cancer Center, The University of Texas, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, The University of Texas, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5012302432","https://openalex.org/A5019866348","https://openalex.org/A5023508449","https://openalex.org/A5027293079","https://openalex.org/A5040502835","https://openalex.org/A5047591504","https://openalex.org/A5047631289","https://openalex.org/A5059959042","https://openalex.org/A5068017392","https://openalex.org/A5081516283","https://openalex.org/A5102919781","https://openalex.org/A5103114173","https://openalex.org/A5108223317","https://openalex.org/A5109000255"],"corresponding_institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I1334287468","https://openalex.org/I196349391","https://openalex.org/I2800281165","https://openalex.org/I2801331674","https://openalex.org/I4210114143","https://openalex.org/I4210155144","https://openalex.org/I4210156160","https://openalex.org/I4210163256","https://openalex.org/I75124487"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.057,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.78802459,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"114","issue":"22","first_page":"3433","last_page":"3433"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ofatumumab","display_name":"ofatumumab","score":0.9710000157356262},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/anti-cd20-monoclonal-antibody","display_name":"anti-CD20 monoclonal antibody","score":0.8619999885559082},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.902999997138977},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.8519999980926514},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.6259999871253967},{"id":"https://openalex.org/keywords/population-pharmacokinetic-model","display_name":"population pharmacokinetic model","score":0.6660000085830688},{"id":"https://openalex.org/keywords/overall-response-rate","display_name":"overall response rate","score":0.7360000014305115},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":1.0},{"id":"https://openalex.org/keywords/baseline-characteristics","display_name":"baseline characteristics","score":0.7070000171661377},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.3840000033378601},{"id":"https://openalex.org/keywords/complement-dependent-cytotoxicity","display_name":"complement-dependent cytotoxicity","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2778714382","wikidata":"https://www.wikidata.org/wiki/Q410656","display_name":"Ofatumumab","level":4,"score":0.9630003571510315},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8210252523422241},{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.7500706911087036},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.6927132606506348},{"id":"https://openalex.org/C2779015954","wikidata":"https://www.wikidata.org/wiki/Q420164","display_name":"Alemtuzumab","level":3,"score":0.6432633996009827},{"id":"https://openalex.org/C2778335254","wikidata":"https://www.wikidata.org/wiki/Q5137314","display_name":"Cmin","level":4,"score":0.6262900233268738},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5910851359367371},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.5275696516036987},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5191313624382019},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5079744458198547},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.48874354362487793},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.479912132024765},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4480472505092621},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39421987533569336},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.24107211828231812},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.19546613097190857},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1878458559513092},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.11883342266082764},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v114.22.3433.3433","doi":"https://doi.org/10.1182/blood.v114.22.3433.3433","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v114.22.3433.3433","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2521573206","https://openalex.org/W2500213562","https://openalex.org/W2094106544","https://openalex.org/W2260958248","https://openalex.org/W2124575836","https://openalex.org/W2597391618","https://openalex.org/W185506919","https://openalex.org/W2466938692","https://openalex.org/W2049353008","https://openalex.org/W2052868810"],"abstract_inverted_index":{"Abstract":[0,1],"3433":[2],"Poster":[3],"Board":[4],"III-321":[5],"Introduction":[6],"Monoclonal":[7],"antibody":[8],"(mAb)":[9],"therapies":[10],"represent":[11],"an":[12,104,167,355,543],"important":[13],"clinical":[14,481],"advance":[15],"for":[16,64,78,178,221,359,409,435,551,631],"patients":[17],"(pts)":[18],"with":[19,66,314,388,431,479],"CLL,":[20],"yet":[21],"little":[22],"is":[23,38,57,489,542],"known":[24],"about":[25],"the":[26,134,279,373,517,526,552],"pharmacokinetics":[27],"(PK)":[28],"and":[29,49,98,113,123,126,130,138,191,224,235,245,248,260,268,288,300,333,342,381,400,417,419,426,475,491,500,523,566,576],"pharmacodynamics":[30],"of":[31,145,174,232,278,286,317,340,391,448,470,494,520,554],"mAb":[32,41],"therapy":[33,522],"in":[34,54,60,96,100,372,394,404,483],"these":[35],"pts.":[36,302],"Ofatumumab":[37,56,541],"a":[39,43,61,207],"human":[40],"targeting":[42],"membrane-proximal":[44],"small-loop":[45],"epitope":[46],"on":[47,376,438],"CD20":[48],"mediates":[50],"efficient":[51],"complement-dependent":[52],"cytotoxicity":[53],"vitro.":[55],"being":[58],"evaluated":[59,118,252],"pivotal":[62,135,487],"trial":[63],"pts":[65,102,281],"fludarabine-refractory":[67],"CLL":[68],"also":[69],"refractory":[70],"to":[71,81,514,524],"alemtuzumab":[72,79],"(FA-ref;":[73],"n=59)":[74],"or":[75,262,272,450],"less":[76],"suitable":[77],"due":[80],"bulky":[82],"(>5":[83],"cm)":[84],"lymphadenopathy":[85],"(BF-ref;":[86],"n=79).":[87],"Overall":[88],"response":[89,392,502,518],"rate":[90],"(ORR;":[91],"primary":[92],"endpoint)":[93],"was":[94,111,164,201,219,311],"58%":[95],"FA-ref":[97,299],"47%":[99],"BF-ref":[101,301],"at":[103,183,308,348,367,383,422,472,506],"interim":[105],"analysis;":[106],"median":[107],"progression-free":[108],"survival":[109],"(PFS)":[110],"5.7":[112],"5.9":[114],"months,":[115],"respectively.":[116],"We":[117],"relationships":[119,240],"between":[120,127,241,258,298,496],"baseline":[121,242,457],"factors":[122,247,362,458],"ofatumumab":[124,146,287,464,471],"PK":[125,128,179,199,249,259,294,365,442,499],"parameters":[129,250,295,366,443],"treatment":[131,347,501,553],"outcomes":[132,482],"from":[133,206],"trial.":[136],"Patients":[137],"Methods":[139],"Pts":[140],"received":[141,282,290],"8":[142,187,223,283,369,385,425,474],"weekly":[143,189,284],"infusions":[144,151,285],"followed":[147],"by":[148,166,253],"4":[149],"monthly":[150,195],"(Dose":[152],"1,":[153,185,217],"300":[154],"mg;":[155],"Doses":[156,222,424,473],"2-12,":[157],"2000":[158],"mg).":[159],"Response":[160],"(1996":[161],"NCI-WG":[162],"criteria)":[163],"assessed":[165],"Independent":[168],"Review":[169],"Committee":[170],"over":[171],"24":[172],"weeks":[173],"therapy.":[175],"Blood":[176,213],"samples":[177],"analysis":[180],"were":[181,237,251,264,296,344,386,402,428,444,477],"collected":[182],"Dose":[184,186,192,216,309,349,368,384],"(last":[188,194],"dose),":[190],"12":[193,292,427,476],"dose).":[196],"A":[197],"population":[198],"model":[200],"employed":[202],"that":[203,363,456],"included":[204],"data":[205,411,454],"previous":[208],"study":[209,488,507],"(Coiffier":[210],"et":[211],"al,":[212],"2008;111:1094).":[214],"For":[215],"Cmax":[218,307,380],"determined;":[220],"12,":[225],"Cmax,":[226,398,415],"Cmin,":[227],"AUC,":[228],"clearance":[229],"(CL),":[230],"volume":[231],"distribution":[233],"(Vss)":[234],"t\u00bd":[236],"determined.":[238],"The":[239,338,486],"pt":[243],"characteristics":[244],"disease":[246,460],"multivariate":[254,269,304,440],"regression":[255,271,274],"analysis.":[256,360],"Associations":[257],"ORR":[261,449],"PFS":[263,433],"explored":[265],"using":[266],"univariate":[267,377,484],"logistic":[270],"Cox":[273],"analyses.":[275,485],"Results":[276],"90%":[277],"154":[280],"55%":[289],"all":[291],"infusions.":[293],"similar":[297],"In":[303],"analysis,":[305],"higher":[306,379,397,467],"1":[310],"significantly":[312,396,429,462],"associated":[313,387,478],"lower":[315,322,326,334,420],"%":[316],"bone":[318],"marrow":[319],"infiltration":[320],"(p<0.001),":[321],"Rai":[323],"stage":[324],"(p=0.002),":[325],"lymphocyte":[327],"count":[328],"(p=0.006),":[329],"smaller":[330],"BSA":[331],"(p<0.001)":[332],"total":[335],"bilirubin":[336],"(p=0.013).":[337],"majority":[339],"responders":[341,405],"non-responders":[343,407],"still":[345],"receiving":[346],"8;":[350],"thus,":[351],"this":[352],"dose":[353],"represents":[354],"informative":[356],"time":[357],"point":[358],"Baseline":[361],"influenced":[364,463],"are":[370],"shown":[371],"table.":[374],"Based":[375,437],"analyses,":[378,441],"Cmin":[382,399,418],"increased":[389],"likelihood":[390],"(Table);":[393],"addition,":[395],"AUC":[401,416],"observed":[403],"versus":[406],"(p<0.05":[408,434],"each;":[410],"not":[412,445],"shown).":[413],"Higher":[414],"CL":[421],"both":[423],"correlated":[430],"longer":[432],"each).":[436],"exploratory":[439],"independent":[446],"predictors":[447],"PFS.":[451],"Conclusions":[452],"These":[453],"demonstrate":[455],"reflecting":[459],"burden":[461],"PK.":[465],"Additionally,":[466],"serum":[468],"concentrations":[469],"positive":[480],"ongoing,":[490],"further":[492],"analyses":[493,510],"associations":[495],"disease-related":[497],"factors,":[498],"will":[503,511],"be":[504],"performed":[505],"completion.":[508],"Such":[509],"help":[512],"us":[513],"better":[515],"understand":[516],"kinetics":[519],"biological":[521],"optimize":[525],"dose.":[527],"Disclosures":[528],"O\u0308sterborg:":[529],"Celgene:":[530],"Honoraria,":[531,535,611,669],"Research":[532,536,604,612,622,670],"Funding;":[533],"GlaxoSmithKline:":[534,668],"Funding.":[537,605,613,623,671],"Off":[538],"Label":[539],"Use:":[540],"investigational":[544],"anti-CD20":[545],"monoclonal":[546],"antibody,":[547],"currently":[548],"under":[549],"development":[550],"B-cell":[555,562],"malignancies":[556],"(chronic":[557],"lymphocytic":[558],"leukemia,":[559],"diffuse":[560],"large":[561],"lymphoma,":[563],"Waldenstroms":[564],"macroglobulinemia":[565],"follicular":[567],"lymphoma)":[568],"as":[569,571],"well":[570],"autoimmune":[572],"diseases":[573],"(rheumatoid":[574],"arthritis":[575],"multiple":[577],"sclerosis).":[578],"Biilmann":[579],"Ronn:Genmab:":[580],"Employment.":[581,646],"Jewell:GlaxoSmithKline:":[582],"Employment,":[583,648,652,656,660,664],"Equity":[584,649,661,665],"Ownership.":[585,650,654,662,666],"Kipps:Physicians'":[586],"Educational":[587,589],"Resource,":[588],"Concepts:":[590],"Speakers":[591,626],"Bureau;":[592],"Genmab,":[593],"Abbott":[594],"Industries,":[595],"Celgene,":[596,639],"Biogen":[597],"Idec,":[598],"Cephalon,":[599],"sanofi-aventis,":[600],"Medimmune,":[601],"Memgem,":[602],"Genentech:":[603,640],"Mayer:GlaxoSmithKline:":[606],"Consultancy.":[607,641,644],"Stilgenbauer:GlaxoSmithKline,":[608],"Genmab:":[609],"Consultancy,":[610,616,625,629,637],"Hellmann:Novartis,":[614],"BMS:":[615],"Honoraria.":[617,635],"Robak:GlaxoSmithKline,":[618],"Roche:":[619],"Advisory":[620,632],"Board,":[621],"Furman:GlaxoSmithKline:":[624],"Bureau.":[627],"Hillmen:GlaxoSmithKline:":[628],"Honoraria":[630],"Boards.":[633],"Trneny:GlaxoSmithKline:":[634],"Padmanabhan:GlaxoSmithKline:":[636],"Honoraria;":[638],"Kozak:GlaxoSmithKline,":[642],"Amgen:":[643],"Chan:GlaxoSmithKline:":[645],"Arning:GlaxoSmithKline:":[647],"Losic:Genmab:":[651],"Stock":[653,657],"Davis:GlaxoSmithKline:":[655],"ownership.":[658],"Wilms:Genmab:":[659],"Russell:Genmab:":[663],"Wierda:Genmab,":[667]},"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}