{"id":"https://openalex.org/W2424676728","doi":"https://doi.org/10.1097/00007611-197805000-00006","title":"Hypertension After Clonidine Withdrawal","display_name":"Hypertension After Clonidine Withdrawal","publication_year":1978,"publication_date":"1978-05-01","ids":{"openalex":"https://openalex.org/W2424676728","doi":"https://doi.org/10.1097/00007611-197805000-00006","mag":"2424676728","pmid":"https://pubmed.ncbi.nlm.nih.gov/644354"},"language":"en","primary_location":{"id":"doi:10.1097/00007611-197805000-00006","doi":"https://doi.org/10.1097/00007611-197805000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007611-197805000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S89143414","display_name":"Southern Medical Journal","issn_l":"0038-4348","issn":["0038-4348","1541-8243"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Southern Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035259264","display_name":"Fred E. Husserl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"FRED E. HUSSERL","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021192809","display_name":"Jose G.R. deCarvalho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JOSE G. R. deCARVALHO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055802823","display_name":"Hugh M. Batson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HUGH M. BATSON","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112042724","display_name":"Edward David Frohlich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"EDWARD D. FROHLICH","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.735,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.85670057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"5","first_page":"496","last_page":"497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rebound-hypertension","display_name":"rebound hypertension","score":0.8180000185966492},{"id":"https://openalex.org/keywords/clonidine-withdrawal","display_name":"clonidine withdrawal","score":0.9900000095367432},{"id":"https://openalex.org/keywords/clonidine","display_name":"clonidine","score":0.8679999709129333},{"id":"https://openalex.org/keywords/hypertensive-crisis","display_name":"hypertensive crisis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/alpha-adrenergic-blockade","display_name":"alpha-adrenergic blockade","score":0.8849999904632568},{"id":"https://openalex.org/keywords/beta-adrenergic-blockade","display_name":"beta-adrenergic blockade","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reserpine","display_name":"reserpine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.9509999752044678}],"concepts":[{"id":"https://openalex.org/C2778399450","wikidata":"https://www.wikidata.org/wiki/Q412221","display_name":"Clonidine","level":2,"score":0.9894421100616455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9308468103408813},{"id":"https://openalex.org/C2777842393","wikidata":"https://www.wikidata.org/wiki/Q407841","display_name":"Reserpine","level":2,"score":0.847766637802124},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6387752294540405},{"id":"https://openalex.org/C2910450144","wikidata":"https://www.wikidata.org/wiki/Q25303605","display_name":"Hypertensive crisis","level":3,"score":0.5296756029129028},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5243406891822815},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4871661365032196},{"id":"https://openalex.org/C2776922375","wikidata":"https://www.wikidata.org/wiki/Q498902","display_name":"Withdrawal syndrome","level":2,"score":0.4456249475479126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3069075047969818},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09117445349693298}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007611-197805000-00006","doi":"https://doi.org/10.1097/00007611-197805000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007611-197805000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S89143414","display_name":"Southern Medical Journal","issn_l":"0038-4348","issn":["0038-4348","1541-8243"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Southern Medical Journal","raw_type":"journal-article"},{"id":"pmid:644354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/644354","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Southern medical journal","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2091048444","https://openalex.org/W7214229964","https://openalex.org/W4233348909","https://openalex.org/W4252964145","https://openalex.org/W4411310535","https://openalex.org/W2022606604","https://openalex.org/W7208904037","https://openalex.org/W2416212927","https://openalex.org/W2092146031","https://openalex.org/W2022907208"],"abstract_inverted_index":{"Rebound":[0],"hypertension":[1],"occurred":[2],"in":[3],"two":[4],"patients":[5],"upon":[6],"clonidine":[7],"withdrawal.":[8],"Treatment":[9],"of":[10,15,26,31],"the":[11,24,34],"hypertensive":[12],"crisis":[13],"consists":[14],"both":[16],"alpha-":[17],"and":[18],"beta-adrenergic":[19],"receptor":[20],"blockade,":[21],"reserpine,":[22],"or":[23],"reintroduction":[25],"clonidine.":[27],"With":[28],"effective":[29],"control":[30],"pressure":[32],"during":[33],"crisis,":[35],"long-term":[36],"antihypertensive":[37],"therapy":[38],"must":[39],"be":[40],"resumed.":[41]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}