{"id":"https://openalex.org/W2424676531","doi":null,"title":"Mechanisms of ischemic injury in the heart.","display_name":"Mechanisms of ischemic injury in the heart.","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W2424676531","mag":"2424676531","pmid":"https://pubmed.ncbi.nlm.nih.gov/3904719"},"language":"en","primary_location":{"id":"pmid:3904719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3904719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic research in cardiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J Schrader","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J Schrader","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7168,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.75398402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"80 Suppl 2","issue":null,"first_page":"135","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/intracellular-ph","display_name":"intracellular pH","score":0.8240000009536743},{"id":"https://openalex.org/keywords/inorganic-phosphate","display_name":"inorganic phosphate","score":0.9330000281333923},{"id":"https://openalex.org/keywords/atp-hydrolysis","display_name":"ATP hydrolysis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.7990000247955322},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/adenine-nucleotide-degradation","display_name":"adenine nucleotide degradation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/inosine","display_name":"inosine","score":0.8769999742507935},{"id":"https://openalex.org/keywords/nucleoside-phosphorylase","display_name":"nucleoside phosphorylase","score":0.9670000076293945},{"id":"https://openalex.org/keywords/coronary-endothelium","display_name":"coronary endothelium","score":0.8840000033378601},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9089999794960022},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.6159999966621399},{"id":"https://openalex.org/keywords/cardiac-cell-membrane","display_name":"cardiac cell membrane","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2781116151","wikidata":"https://www.wikidata.org/wiki/Q410305","display_name":"Hypoxanthine","level":3,"score":0.8816570043563843},{"id":"https://openalex.org/C2777610669","wikidata":"https://www.wikidata.org/wiki/Q422564","display_name":"Inosine","level":3,"score":0.7494555711746216},{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.6921274662017822},{"id":"https://openalex.org/C71615608","wikidata":"https://www.wikidata.org/wiki/Q24720082","display_name":"Purine nucleoside phosphorylase","level":4,"score":0.6806632280349731},{"id":"https://openalex.org/C2779470414","wikidata":"https://www.wikidata.org/wiki/Q50980","display_name":"Xanthine","level":3,"score":0.5594475269317627},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5287565588951111},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.5141820907592773},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4996340274810791},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4870074391365051},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4350036084651947},{"id":"https://openalex.org/C2994266630","wikidata":"https://www.wikidata.org/wiki/Q424021","display_name":"Adenine nucleotide","level":4,"score":0.42667803168296814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42259982228279114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3290288746356964},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.32015711069107056},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.29416030645370483},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22343629598617554},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.19743859767913818},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.17509961128234863},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012508","descriptor_name":"Sarcolemma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012508","descriptor_name":"Sarcolemma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014969","descriptor_name":"Xanthine Oxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3904719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3904719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic research in cardiology","raw_type":"Journal Article"},{"id":"mag:2424676531","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3904719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W109036740","https://openalex.org/W107445082","https://openalex.org/W1758173193","https://openalex.org/W82602973","https://openalex.org/W4242633862","https://openalex.org/W1491240105","https://openalex.org/W2034683799","https://openalex.org/W581165343","https://openalex.org/W2414094929","https://openalex.org/W2268050092"],"abstract_inverted_index":{"Cardiac":[0],"ischemia":[1],"is":[2,68,119],"characterized":[3],"by":[4,139],"rapid":[5],"deterioration":[6],"of":[7,22,31,47,72,88,94,104,126],"cardiac":[8,49],"function,":[9],"which":[10,43],"has":[11],"been":[12],"linked":[13],"to":[14,85,91,106],"the":[15,45,48,64,81,86,92,115,123,130,135],"fall":[16],"in":[17,27,53,63,80,99,114,129],"intracellular":[18],"pH,":[19],"increased":[20],"levels":[21],"inorganic":[23],"phosphate":[24],"and":[25,97,109],"reduction":[26],"free":[28,56,73,140],"energy":[29],"change":[30,44],"ATP-hydrolysis.":[32],"Biochemical":[33],"events":[34],"responsible":[35],"for":[36],"irreversible":[37],"myocardial":[38],"injury":[39,128],"involve":[40],"various":[41],"mechanisms":[42],"properties":[46],"cell":[50],"membrane":[51],"(disorders":[52],"lipid":[54],"metabolism,":[55],"radical":[57,74],"formation).":[58],"Recent":[59],"evidence":[60],"suggests":[61],"that":[62,122],"heart,":[65],"xanthine":[66,108],"oxidase":[67],"a":[69],"major":[70],"source":[71],"formation.":[75],"During":[76],"ischemia,":[77],"adenine-nucleotide":[78],"breakdown":[79],"cardiomyocyte":[82],"proceeds":[83],"only":[84],"stage":[87],"inosine.":[89],"Due":[90],"localisation":[93],"nucleoside":[95],"phosphorylase":[96],"xanthine-oxidase":[98],"vascular":[100,116],"endothelium,":[101],"further":[102],"degradation":[103],"inosine":[105],"hypoxanthine,":[107],"uric":[110],"acid":[111],"occurs":[112],"predominantly":[113],"space.":[117],"It":[118],"therefore":[120],"conceivable":[121],"primary":[124],"site":[125],"reperfusion":[127],"ischemic":[131],"heart":[132],"may":[133],"be":[134],"coronary":[136],"endothelium":[137],"damaged":[138],"radicals.":[141]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
