{"id":"https://openalex.org/W2424379727","doi":"https://doi.org/10.1385/1-59259-291-0:173","title":"HLA Typing With Reference Strand-Mediated Conformation Analysis","display_name":"HLA Typing With Reference Strand-Mediated Conformation Analysis","publication_year":2003,"publication_date":"2003-11-15","ids":{"openalex":"https://openalex.org/W2424379727","doi":"https://doi.org/10.1385/1-59259-291-0:173","mag":"2424379727","pmid":"https://pubmed.ncbi.nlm.nih.gov/12412455"},"language":"en","primary_location":{"id":"doi:10.1385/1-59259-291-0:173","doi":"https://doi.org/10.1385/1-59259-291-0:173","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59259-291-0:173","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MHC Protocols","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4235515193","display_name":"MHC Protocols"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112277812","display_name":"J. Rafael Arguello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800598996","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800598996"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Rafael Arg\u00fcello","raw_affiliation_strings":["Anthony Nolan Research Institute, London, United Kingdom","Anthony Nolan Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anthony Nolan Research Institute, London, United Kingdom","institution_ids":["https://openalex.org/I2800598996"]},{"raw_affiliation_string":"Anthony Nolan Research Institute","institution_ids":["https://openalex.org/I2800598996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079935947","display_name":"Martha P\u00e9rez\u2010Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-1265-7769","observed_orcids":["https://orcid.org/0000-0002-1265-7769"]},"institutions":[{"id":"https://openalex.org/I2800598996","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800598996"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martha P\u00e9rez-Rodr\u00edguez","raw_affiliation_strings":["Anthony Nolan Research Institute, London, UK","Anthony Nolan Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anthony Nolan Research Institute, London, UK","institution_ids":["https://openalex.org/I2800598996"]},{"raw_affiliation_string":"Anthony Nolan Research Institute","institution_ids":["https://openalex.org/I2800598996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111409671","display_name":"Andrea L. Pay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800598996","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800598996"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrea Pay","raw_affiliation_strings":["Anthony Nolan Research Institute, London, UK","Anthony Nolan Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anthony Nolan Research Institute, London, UK","institution_ids":["https://openalex.org/I2800598996"]},{"raw_affiliation_string":"Anthony Nolan Research Institute","institution_ids":["https://openalex.org/I2800598996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040734072","display_name":"Gaby Fisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800598996","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800598996"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gaby Fisher","raw_affiliation_strings":["Anthony Nolan Research Institute, London, UK","Anthony Nolan Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anthony Nolan Research Institute, London, UK","institution_ids":["https://openalex.org/I2800598996"]},{"raw_affiliation_string":"Anthony Nolan Research Institute","institution_ids":["https://openalex.org/I2800598996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108495533","display_name":"Alasdair McWhinnie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800598996","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800598996"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alasdair McWhinnie","raw_affiliation_strings":["Anthony Nolan Research Institute, London, UK","Anthony Nolan Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anthony Nolan Research Institute, London, UK","institution_ids":["https://openalex.org/I2800598996"]},{"raw_affiliation_string":"Anthony Nolan Research Institute","institution_ids":["https://openalex.org/I2800598996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020482451","display_name":"J. Alejandro Madrigal","orcid":"https://orcid.org/0000-0001-8359-9917","observed_orcids":["https://orcid.org/0000-0001-8359-9917"]},"institutions":[{"id":"https://openalex.org/I2800598996","display_name":"Anthony Nolan","ror":"https://ror.org/043bfms20","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800598996"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Alejandro Madrigal","raw_affiliation_strings":["Anthony Nolan Research Institute, London, UK","Anthony Nolan Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anthony Nolan Research Institute, London, UK","institution_ids":["https://openalex.org/I2800598996"]},{"raw_affiliation_string":"Anthony Nolan Research Institute","institution_ids":["https://openalex.org/I2800598996"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800598996"],"apc_list":null,"apc_paid":null,"fwci":1.6476,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.85200625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"210","issue":null,"first_page":"173","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.1340000033378601,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.1340000033378601,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.11819999665021896,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.07599999755620956,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-typing","display_name":"HLA typing","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hla-alleles","display_name":"HLA alleles","score":0.7390000224113464},{"id":"https://openalex.org/keywords/sequence-motifs","display_name":"sequence motifs","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.8750604391098022},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.8073529005050659},{"id":"https://openalex.org/C2781209916","wikidata":"https://www.wikidata.org/wiki/Q3215756","display_name":"Typing","level":2,"score":0.761128306388855},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7163875699043274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6415747404098511},{"id":"https://openalex.org/C117745874","wikidata":"https://www.wikidata.org/wiki/Q901612","display_name":"Sequence motif","level":3,"score":0.5618767142295837},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46680596470832825},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.22534850239753723},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19544634222984314}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006650","descriptor_name":"Histocompatibility Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008285","descriptor_name":"Major Histocompatibility Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018807","descriptor_name":"Polymorphism, Single-Stranded Conformational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1385/1-59259-291-0:173","doi":"https://doi.org/10.1385/1-59259-291-0:173","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59259-291-0:173","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MHC Protocols","raw_type":"book-chapter"},{"id":"pmid:12412455","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12412455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1513891980","https://openalex.org/W1987802717","https://openalex.org/W1993144976","https://openalex.org/W2027840113","https://openalex.org/W2029972048","https://openalex.org/W2031691024","https://openalex.org/W2036376231","https://openalex.org/W2037268137","https://openalex.org/W2048791531","https://openalex.org/W2083625623","https://openalex.org/W2085914386"],"related_works":["https://openalex.org/W6990479543","https://openalex.org/W2368018040","https://openalex.org/W2069431951","https://openalex.org/W2142434398","https://openalex.org/W1967099206","https://openalex.org/W3161539798","https://openalex.org/W2051394557","https://openalex.org/W4251883273","https://openalex.org/W4237975062","https://openalex.org/W2035530518"],"abstract_inverted_index":{"Comparison":[0],"of":[1,18,55],"HLA":[2],"allelic":[3],"sequences":[4,37],"reveals":[5],"a":[6,32,73],"patchwork":[7],"pattern":[8],"in":[9,42,67,89],"which":[10,71],"individual":[11,23],"alleles":[12,34,44],"are":[13,39],"defined":[14],"by":[15,112,116],"unique":[16],"combinations":[17],"sequence":[19],"motifs.":[20],"Although":[21],"each":[22],"motif":[24,75],"may":[25,126],"be":[26,87,127],"shared":[27],"with":[28],"other":[29,43],"alleles,":[30],"only":[31],"few":[33],"have":[35],"specific":[36],"that":[38],"not":[40,115],"present":[41],"(":[45,77,103],"1":[46],").":[47,79,107],"Thus":[48],"the":[49,96,117,124,130],"main":[50],"problem":[51],"facing":[52],"conventional":[53],"methods":[54],"human":[56],"leukocyte":[57],"antigen":[58],"(HLA)":[59],"typing":[60],"is":[61,121],"their":[62],"inherent":[63],"inability":[64],"to":[65,70,93],"determine,":[66],"heterozygous":[68],"individuals,":[69],"allele":[72,84],"particular":[74],"belongs":[76],"2":[78],"To":[80],"overcome":[81],"this":[82],"problem,":[83],"separation":[85],"must":[86],"performed":[88],"some":[90],"samples":[91],"prior":[92],"typing,":[94],"making":[95],"whole":[97],"procedure":[98],"technically":[99],"labor-intensive":[100],"and":[101,114,123],"time-consuming":[102],"3":[104],",":[105],"4":[106],"These":[108],"keywords":[109,125],"were":[110],"added":[111],"machine":[113],"authors.":[118],"This":[119],"process":[120],"experimental":[122],"updated":[128],"as":[129],"learning":[131],"algorithm":[132],"improves.":[133]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}