{"id":"https://openalex.org/W2424348693","doi":"https://doi.org/10.1042/cs0770237","title":"Chronobiological Study of the Relationship between Dyspnoea and Airway Obstruction in Symptomatic Asthmatic Subjects","display_name":"Chronobiological Study of the Relationship between Dyspnoea and Airway Obstruction in Symptomatic Asthmatic Subjects","publication_year":1989,"publication_date":"1989-09-01","ids":{"openalex":"https://openalex.org/W2424348693","doi":"https://doi.org/10.1042/cs0770237","mag":"2424348693","pmid":"https://pubmed.ncbi.nlm.nih.gov/2805590"},"language":"en","primary_location":{"id":"doi:10.1042/cs0770237","doi":"https://doi.org/10.1042/cs0770237","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs0770237","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047620886","display_name":"Claudine Peiffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C. Peiffer","raw_affiliation_strings":["D\u00e9partement de Pneumologie, H\u00f4pital Cochin, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Pneumologie, H\u00f4pital Cochin, Paris, France","institution_ids":["https://openalex.org/I4210092774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063401106","display_name":"Jean Marsac","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Marsac","raw_affiliation_strings":["D\u00e9partement de Pneumologie, H\u00f4pital Cochin, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Pneumologie, H\u00f4pital Cochin, Paris, France","institution_ids":["https://openalex.org/I4210092774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013303239","display_name":"Alain Lockhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092774","display_name":"H\u00f4pital Cochin","ror":"https://ror.org/00ph8tk69","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210092774","https://openalex.org/I4210097159","https://openalex.org/I4210124464"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Lockhart","raw_affiliation_strings":["D\u00e9partement de Pneumologie, H\u00f4pital Cochin, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Pneumologie, H\u00f4pital Cochin, Paris, France","institution_ids":["https://openalex.org/I4210092774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210092774"],"apc_list":null,"apc_paid":null,"fwci":3.0748,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.90779308,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"77","issue":"3","first_page":"237","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9580000042915344},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.9670000076293945},{"id":"https://openalex.org/keywords/airway-obstruction","display_name":"airway obstruction","score":0.9160000085830688},{"id":"https://openalex.org/keywords/peak-expiratory-flow","display_name":"peak expiratory flow","score":0.9639999866485596},{"id":"https://openalex.org/keywords/chronobiology","display_name":"chronobiology","score":0.7870000004768372},{"id":"https://openalex.org/keywords/diurnal-variation","display_name":"diurnal variation","score":0.6790000200271606},{"id":"https://openalex.org/keywords/visual-analog-scale","display_name":"visual analogue scale","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7196903824806213},{"id":"https://openalex.org/C2778333281","wikidata":"https://www.wikidata.org/wiki/Q4330029","display_name":"Airway obstruction","level":3,"score":0.6778656244277954},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6568775177001953},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.46505388617515564},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.41908296942710876},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.37959665060043335},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3720659613609314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3416779637336731}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000402","descriptor_name":"Airway Obstruction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000402","descriptor_name":"Airway Obstruction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001294","descriptor_name":"Attitude to Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004417","descriptor_name":"Dyspnea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004417","descriptor_name":"Dyspnea","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010366","descriptor_name":"Peak Expiratory Flow Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1042/cs0770237","doi":"https://doi.org/10.1042/cs0770237","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs0770237","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},{"id":"pmid:2805590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2805590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical science (London, England : 1979)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2418543025","https://openalex.org/W2419521545","https://openalex.org/W2023141196","https://openalex.org/W2152177684","https://openalex.org/W2149172132","https://openalex.org/W2159470992","https://openalex.org/W2108389895","https://openalex.org/W2134057543","https://openalex.org/W2052205043","https://openalex.org/W2062418539"],"abstract_inverted_index":{"1.":[0],"We":[1,154],"performed":[2],"a":[3,83,163,191],"chronobiological":[4],"study":[5,225],"of":[6,17,48,182,194,213,217,236,238,253],"the":[7,40,49,76,104,149,234],"relationship":[8],"between":[9,98,110,137],"peak":[10],"expiratory":[11],"flow":[12],"rate":[13],"(PEFR)":[14],"and":[15,34,44,59,70,87,101,112,140,197,230],"magnitude":[16],"dyspnoea":[18,81,99,138,198,218],"in":[19,66,200,203,233,242],"35":[20,105],"symptomatic":[21],"asthmatic":[22,28,243],"patients":[23],"to":[24,121,165,177,247,250],"determine":[25],"how":[26],"accurately":[27],"subjects":[29,50,77,106,244],"assess":[30],"spontaneous":[31,239],"airway":[32,183,240],"obstruction":[33,241],"whether":[35],"this":[36],"accuracy":[37,235],"varies":[38],"throughout":[39],"24":[41],"h":[42],"period":[43],"depends":[45],"on":[46,62],"characteristics":[47,252],"or":[51,175,211,221],"asthma.":[52,254],"2.":[53],"At":[54],"07.00,":[55],"11.00,":[56],"15.00,":[57],"19.00":[58],"23.00":[60],"hours":[61],"8":[63],"consecutive":[64],"days":[65],"their":[67,72,80,91],"ordinary":[68],"environment":[69],"under":[71],"usual":[73],"drug":[74],"regimen,":[75],"first":[78],"rated":[79],"with":[82,114,148],"visual":[84],"analogue":[85],"scale":[86],"immediately":[88],"after":[89],"recorded":[90],"PEFR.":[92],"3.":[93],"The":[94,123],"linear":[95],"regression":[96],"coefficients":[97],"score":[100,139,199],"PEFR":[102,141,151,196],"for":[103,208],"were":[107],"continuously":[108],"distributed":[109],"-0.93":[111],"+0.21,":[113],"most":[115,251],"r":[116,126,156,172],"values":[117,127],"ranging":[118],"from":[119,179],"-0.9":[120],"-0.5.":[122],"group":[124],"median":[125],"calculated":[128],"at":[129,143],"each":[130],"time":[131],"point":[132],"showed":[133],"that":[134],"strongest":[135],"correlation":[136],"occurred":[142],"7":[144],"h.":[145],"which":[146,245],"coincided":[147],"lowest":[150],"values.":[152],"4.":[153],"chose":[155],"=":[157,160],"-0.7":[158],"(r2":[159],"0.5)":[161],"as":[162],"limit":[164],"distinguish":[166],"good":[167,201],"perceivers":[168,181],"(-1":[169],"less":[170,173],"than":[171,174,202],"equal":[176],"-0.7)":[178],"bad":[180,204],"obstruction.":[184],"These":[185],"two":[186],"populations":[187],"differed":[188],"only":[189],"by":[190],"higher":[192],"variability":[193,232],"both":[195],"perceivers,":[205],"but":[206],"not":[207],"severity,":[209],"duration":[210],"treatment":[212],"asthma,":[214],"absolute":[215],"value":[216],"score,":[219],"age":[220],"sex.":[222],"5.":[223],"Our":[224],"quantified":[226],"an":[227],"important":[228],"intra-":[229],"between-subject":[231],"perception":[237],"seems":[246],"be":[248],"unrelated":[249]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}