{"id":"https://openalex.org/W2424253543","doi":null,"title":"The role of retinal ganglion cell axons in the regulation of glial cell numbers in the rodent optic nerve","display_name":"The role of retinal ganglion cell axons in the regulation of glial cell numbers in the rodent optic nerve","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2424253543","mag":"2424253543"},"language":"en","primary_location":{"id":"pmh:hdl:10068/610312","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/610312","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109207728","display_name":"Julia F. Burne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Julia F. Burne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109207728"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.3082999885082245,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.07129999995231628,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinal-ganglion-cell-axons","display_name":"retinal ganglion cell axons","score":0.9549999833106995},{"id":"https://openalex.org/keywords/optic-nerve","display_name":"optic nerve","score":0.8629999756813049},{"id":"https://openalex.org/keywords/glial-proliferation","display_name":"glial cell proliferation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8389999866485596},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":1.0},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8149999976158142},{"id":"https://openalex.org/keywords/wallerian-degeneration","display_name":"Wallerian degeneration","score":0.9039999842643738},{"id":"https://openalex.org/keywords/axonal-transection","display_name":"axon transection","score":0.5690000057220459},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.8090000152587891},{"id":"https://openalex.org/keywords/axonal-transport","display_name":"axonal transport","score":0.8420000076293945},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.8429999947547913},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.7743998765945435},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7448990345001221},{"id":"https://openalex.org/C2780862704","wikidata":"https://www.wikidata.org/wiki/Q1753825","display_name":"Wallerian degeneration","level":2,"score":0.7136503458023071},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6994429230690002},{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.6962167620658875},{"id":"https://openalex.org/C2780837183","wikidata":"https://www.wikidata.org/wiki/Q186029","display_name":"Optic nerve","level":2,"score":0.6431117057800293},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5451468825340271},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5243594646453857},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.4369969367980957},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.43158721923828125},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2215399444103241}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:hdl:10068/610312","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/610312","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10097978","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10097978/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:2424253543","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/264697","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W1492194725","https://openalex.org/W1528196156","https://openalex.org/W1542171240","https://openalex.org/W1566984812","https://openalex.org/W1589415602","https://openalex.org/W1600079321","https://openalex.org/W1646378775","https://openalex.org/W1651988031","https://openalex.org/W1819555985","https://openalex.org/W1967335377","https://openalex.org/W1968222822","https://openalex.org/W1969032559","https://openalex.org/W1972126439","https://openalex.org/W1972744392","https://openalex.org/W1973336785","https://openalex.org/W1977707442","https://openalex.org/W1979099601","https://openalex.org/W1982110534","https://openalex.org/W1982784171","https://openalex.org/W1986591865","https://openalex.org/W1992305552","https://openalex.org/W1992656072","https://openalex.org/W1993336052","https://openalex.org/W1993345461","https://openalex.org/W1993942938","https://openalex.org/W1995954654","https://openalex.org/W1996995775","https://openalex.org/W1997831655","https://openalex.org/W1998225973","https://openalex.org/W1999379822","https://openalex.org/W2004093508","https://openalex.org/W2004550343","https://openalex.org/W2006397229","https://openalex.org/W2007434276","https://openalex.org/W2011137252","https://openalex.org/W2015340853","https://openalex.org/W2020315449","https://openalex.org/W2020333978","https://openalex.org/W2023583278","https://openalex.org/W2025545135","https://openalex.org/W2026886935","https://openalex.org/W2029722148","https://openalex.org/W2033828028","https://openalex.org/W2035250926","https://openalex.org/W2038231740","https://openalex.org/W2040286934","https://openalex.org/W2041657216","https://openalex.org/W2045308252","https://openalex.org/W2048721919","https://openalex.org/W2050601632","https://openalex.org/W2052115387","https://openalex.org/W2053623203","https://openalex.org/W2055451031","https://openalex.org/W2064183906","https://openalex.org/W2069400562","https://openalex.org/W2073465590","https://openalex.org/W2074558188","https://openalex.org/W2075581714","https://openalex.org/W2076682664","https://openalex.org/W2076776277","https://openalex.org/W2077298061","https://openalex.org/W2077439063","https://openalex.org/W2078001244","https://openalex.org/W2081560586","https://openalex.org/W2083561654","https://openalex.org/W2084224225","https://openalex.org/W2084602457","https://openalex.org/W2087459771","https://openalex.org/W2088919486","https://openalex.org/W2089389165","https://openalex.org/W2089558197","https://openalex.org/W2091088099","https://openalex.org/W2091403769","https://openalex.org/W2094859123","https://openalex.org/W2098335369","https://openalex.org/W2099971914","https://openalex.org/W2104978120","https://openalex.org/W2115940913","https://openalex.org/W2118741542","https://openalex.org/W2122268695","https://openalex.org/W2123113903","https://openalex.org/W2127208829","https://openalex.org/W2139331313","https://openalex.org/W2147622529","https://openalex.org/W2152353759","https://openalex.org/W2154745705","https://openalex.org/W2159350004","https://openalex.org/W2159425270","https://openalex.org/W2159654540","https://openalex.org/W2165278466","https://openalex.org/W2166442909","https://openalex.org/W2167962847","https://openalex.org/W2169813593","https://openalex.org/W2169926615","https://openalex.org/W2185470342","https://openalex.org/W2187894771","https://openalex.org/W2408043804","https://openalex.org/W2412174673"],"related_works":["https://openalex.org/W2169926615","https://openalex.org/W1969032559","https://openalex.org/W1551549641","https://openalex.org/W2049296829","https://openalex.org/W2004093508","https://openalex.org/W2131894968","https://openalex.org/W2092709998","https://openalex.org/W2017434751","https://openalex.org/W1969297903","https://openalex.org/W2068950615"],"abstract_inverted_index":{"The":[0,28,54,94],"effect":[1,161,267],"of":[2,32,44,56,96,116,127,133,144,162,252,256,268,280,285],"increased":[3,101,125,131,142,145],"optic":[4,49,106,183,253],"nerve":[5,50,254],"axon":[6,71,81,163],"number":[7,43],"on":[8,154],"glial":[9],"cell":[10,35,63,67,138,228,292],"numbers":[11,95,126],"was":[12,38,51,72,89,111,120,177,208],"studied":[13],"in":[14,46,59,91,103,113,136,181,185,205],"a":[15,25,134,249],"transgenic":[16,105],"mouse":[17,189],"that":[18,171,198,217,235,277,289],"expresses":[19],"the":[20,42,47,62,70,79,92,104,109,124,160,179,186,191,206,218,227,231,258,269,286],"human":[21,57,87],"bcl-2":[22],"gene":[23],"from":[24,65,82,226],"neuron-specific-enolase":[26],"promoter.":[27],"normal":[29,137],"postnatal":[30],"loss":[31],"retinal":[33],"ganglion":[34],"(RGC)":[36],"axons":[37,45,155,192,207,211,281],"decreased":[39],"and,":[40],"consequently,":[41],"adult":[48],"80%":[52],"greater.":[53],"expression":[55],"Bcl-2":[58,88],"RGCs":[60,237,245],"protected":[61],"body":[64,229],"programmed":[66,291],"death":[68],"when":[69,244],"cut,":[73],"but":[74,118,201],"it":[75],"did":[76,193],"not":[77,121,194,202],"protect":[78],"isolated":[80],"Wallerian":[83,167,278],"degeneration,":[84],"even":[85],"though":[86],"present":[90],"axon.":[93,232],"both":[97,114],"oligodendrocytes":[98],"and":[99,169],"astrocytes":[100,141,240],"proportionally":[102],"nerve.":[107],"Unexpectedly,":[108],"transgene":[110],"expressed":[112],"types":[115],"glia,":[117],"this":[119,172,266],"responsible":[122],"for":[123,210],"these":[128],"cells.":[129],"Oligodendrocytes":[130],"because":[132,143],"decrease":[135],"death,":[139],"whereas":[140],"proliferation.":[146],"To":[147],"investigate":[148],"whether":[149],"astrocyte":[150,174,214,220],"proliferation":[151],"normally":[152],"depends":[153],"I":[156,196,233,272],"looked":[157],"first":[158],"at":[159],"removal":[164],"induced":[165],"by":[166],"degeneration":[168,279],"found":[170,197,274],"stopped":[173],"division.":[175],"This":[176],"also":[178],"case":[180],"cut":[182],"nerves":[184],"Wlds":[187],"mutant":[188],"where":[190],"degenerate.":[195],"axonal":[199],"transport,":[200],"electrical":[203],"activity":[204],"required":[209],"to":[212,230,241],"stimulate":[213,239],"division,":[215],"suggesting":[216],"putative":[219],"mitogen":[221],"must":[222],"be":[223],"continuously":[224],"transported":[225],"showed":[234],"purified":[236],"can":[238],"synthesise":[242],"DNA":[243],"were":[246],"co-cultured":[247],"with":[248],"mixed":[250],"population":[251],"cells;":[255],"all":[257],"signalling":[259],"molecules":[260],"tested,":[261],"only":[262],"bFGF":[263],"could":[264],"mimic":[265],"RGCs.":[270],"Finally":[271],"have":[273],"weak":[275],"evidence":[276],"may":[282],"utilise":[283],"some":[284],"proteases":[287],"(caspases)":[288],"mediate":[290],"death.":[293]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
