{"id":"https://openalex.org/W2423919082","doi":null,"title":"Human beta-defensin-2 in oral cancer with opportunistic Candida infection.","display_name":"Human beta-defensin-2 in oral cancer with opportunistic Candida infection.","publication_year":2004,"publication_date":"2004-03-01","ids":{"openalex":"https://openalex.org/W2423919082","mag":"2423919082","pmid":"https://pubmed.ncbi.nlm.nih.gov/15161058"},"language":"en","primary_location":{"id":"pmid:15161058","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15161058","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037920495","display_name":"Jens Eduard Meyer","orcid":"https://orcid.org/0000-0002-6766-4237","observed_orcids":["https://orcid.org/0000-0002-6766-4237"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jens Eduard Meyer","raw_affiliation_strings":["Department of Otorhinolaryngology, Head and Neck Surgery, University of Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany. jmeyer@hno.uni-kiel.de","Department of Otorhinolaryngology, Head and Neck Surgery, University of Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Head and Neck Surgery, University of Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany. jmeyer@hno.uni-kiel.de","institution_ids":["https://openalex.org/I32021983","https://openalex.org/I4210112713"]},{"raw_affiliation_string":"Department of Otorhinolaryngology, Head and Neck Surgery, University of Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany","institution_ids":["https://openalex.org/I32021983","https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074088715","display_name":"J\u00fcrgen Harder","orcid":"https://orcid.org/0000-0002-4075-4603","observed_orcids":["https://orcid.org/0000-0002-4075-4603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Harder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016885020","display_name":"Tibor G\u00f6r\u00f6gh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tibor G\u00f6r\u00f6gh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109171442","display_name":"Jan Bernd Weise","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Bernd Weise","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062096566","display_name":"Sabine Schubert","orcid":"https://orcid.org/0000-0001-6788-171X","observed_orcids":["https://orcid.org/0000-0001-6788-171X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabine Schubert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Dirk Janssen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dirk Janssen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000462527","display_name":"Steffen Maune","orcid":"https://orcid.org/0000-0002-0858-8705","observed_orcids":["https://orcid.org/0000-0002-0858-8705"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steffen Maune","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6538,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.81728395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"24","issue":"2B","first_page":"1025","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.7714999914169312,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.20520000159740448,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-beta-defensin-2","display_name":"human beta-defensin 2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9919999837875366},{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.7770000100135803},{"id":"https://openalex.org/keywords/opportunistic-fungal-infection","display_name":"opportunistic fungal infection","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tonsillar-cancer","display_name":"tonsillar carcinoma","score":0.7820000052452087},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.8679999709129333},{"id":"https://openalex.org/keywords/betamethasone","display_name":"betamethasone","score":0.7369999885559082},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8659999966621399},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7860000133514404},{"id":"https://openalex.org/keywords/epithelial-cells","display_name":"epithelial cells","score":0.5920000076293945},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.8700000047683716},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.6980000138282776},{"id":"https://openalex.org/keywords/candida-colonization","display_name":"Candida colonization","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.8206470608711243},{"id":"https://openalex.org/C2776498113","wikidata":"https://www.wikidata.org/wiki/Q412820","display_name":"Defensin","level":3,"score":0.6763458251953125},{"id":"https://openalex.org/C129437159","wikidata":"https://www.wikidata.org/wiki/Q4897294","display_name":"Beta defensin","level":4,"score":0.6470865607261658},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6128978729248047},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5909949541091919},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5903980135917664},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5327731370925903},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5327019691467285},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.5198208093643188},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4226763844490051},{"id":"https://openalex.org/C2781162121","wikidata":"https://www.wikidata.org/wiki/Q416132","display_name":"Betamethasone","level":2,"score":0.4215676486492157},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.4104255437850952},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40921550989151},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.30891844630241394},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001623","descriptor_name":"Betamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009894","descriptor_name":"Opportunistic Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009894","descriptor_name":"Opportunistic Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009894","descriptor_name":"Opportunistic Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009894","descriptor_name":"Opportunistic Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014066","descriptor_name":"Palatine Tonsil","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014067","descriptor_name":"Tonsillar Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014067","descriptor_name":"Tonsillar Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014067","descriptor_name":"Tonsillar Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D023083","descriptor_name":"beta-Defensins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15161058","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15161058","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2423919082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15161058","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W14301900","https://openalex.org/W126137108","https://openalex.org/W144307537","https://openalex.org/W1745264954","https://openalex.org/W1965135642","https://openalex.org/W1987913143","https://openalex.org/W1988171160","https://openalex.org/W1988228153","https://openalex.org/W1997670712","https://openalex.org/W2017817339","https://openalex.org/W2063411604","https://openalex.org/W2082574558","https://openalex.org/W2082787466","https://openalex.org/W2116697371","https://openalex.org/W2124035973","https://openalex.org/W2128315833","https://openalex.org/W2160331357","https://openalex.org/W2170442599","https://openalex.org/W2398137194"],"related_works":["https://openalex.org/W2370329071","https://openalex.org/W2151601011","https://openalex.org/W2063411604","https://openalex.org/W2165935955","https://openalex.org/W2082306467","https://openalex.org/W2957346305","https://openalex.org/W2129168863","https://openalex.org/W1987913143","https://openalex.org/W2324002875","https://openalex.org/W2006602361"],"abstract_inverted_index":{"Candida":[0,79,166],"albicans":[1,80],"(CA)":[2],"is":[3],"a":[4,29,58,82,119,128,159],"frequent":[5],"opportunistic":[6,65,113],"pathogen":[7],"in":[8,43,81,118],"cancer":[9],"patients.":[10],"Usually,":[11],"human":[12,24],"surfaces":[13],"are":[14],"protected,":[15],"apart":[16],"from":[17,94],"physical":[18],"barriers,":[19],"by":[20,106],"the":[21],"production":[22],"of":[23,60,67,146,153],"beta-defensins":[25],"(hBD).":[26],"hBD-2":[27,41,52,61,102,116,125,154,161],"shows":[28],"potent":[30],"antimicrobial":[31],"activity":[32],"against":[33],"CA.":[34],"We":[35],"therefore":[36],"investigated":[37],"whether":[38,57],"CA":[39,114],"induces":[40,151],"expression":[42,62,103,117,155,162],"primary":[44],"oral":[45,71,95,169],"cells":[46,73,96],"and":[47,74,84,97,101,121,156,163],"if":[48],"immunosuppressive":[49],"betamethasone":[50,90],"alters":[51],"expression.":[53],"Additionally,":[54],"we":[55],"studied,":[56],"lack":[59],"could":[63,137],"explain":[64],"infection":[66],"tonsillar":[68],"cancer.":[69],"Primary":[70],"epithelial":[72],"fibroblasts":[75],"were":[76],"stimulated":[77],"with":[78,87,135],"time-":[83,120],"dose-dependent":[85,122],"manner":[86],"or":[88],"without":[89],"preincubation.":[91],"Total":[92],"RNA":[93],"specimens":[98],"was":[99,104],"isolated":[100],"analyzed":[105],"semiquantitative":[107],"RT-PCR.":[108],"Our":[109],"data":[110],"demonstrate":[111],"that":[112],"induced":[115],"manner,":[123],"suggesting":[124],"to":[126,139,158,165],"be":[127],"fast":[129],"antifungal,":[130],"epithelia-derived":[131],"immune":[132],"response.":[133],"Treatment":[134],"glucocorticoid":[136],"lead":[138],"diminished":[140],"innate":[141],"immunity":[142],"based":[143],"on":[144,168],"suppression":[145],"inducible":[147],"AP.":[148],"Malignant":[149],"transformation":[150],"alteration":[152],"leads":[157],"reduced":[160],"subsequentially":[164],"colonization":[167],"SCCs.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
