{"id":"https://openalex.org/W2423906174","doi":null,"title":"Time course degeneration and expression of glial fibrillary acidic protein in mer-knockout mice.","display_name":"Time course degeneration and expression of glial fibrillary acidic protein in mer-knockout mice.","publication_year":2010,"publication_date":"2010-04-05","ids":{"openalex":"https://openalex.org/W2423906174","mag":"2423906174","pmid":"https://pubmed.ncbi.nlm.nih.gov/20497693"},"language":"en","primary_location":{"id":"pmid:20497693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20497693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052474035","display_name":"Xiaoying Liang","orcid":"https://orcid.org/0000-0002-6688-1045","observed_orcids":["https://orcid.org/0000-0002-6688-1045"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Ying Liang","raw_affiliation_strings":["Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China","Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]},{"raw_affiliation_string":"Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054771496","display_name":"Huaizhou Wang","orcid":"https://orcid.org/0000-0002-4126-100X","observed_orcids":["https://orcid.org/0000-0002-4126-100X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huai-Zhou Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100360133","display_name":"Ningli Wang","orcid":"https://orcid.org/0000-0002-8933-4482","observed_orcids":["https://orcid.org/0000-0002-8933-4482","https://orcid.org/0000-0002-8686-0954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ning-Li Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3365,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.70590107,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"123","issue":"7","first_page":"949","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9769999980926514},{"id":"https://openalex.org/keywords/muller-cells","display_name":"M\u00fcller cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.9430000185966492},{"id":"https://openalex.org/keywords/retinal-ganglion-cell-loss","display_name":"retinal ganglion cell death","score":0.6430000066757202},{"id":"https://openalex.org/keywords/retinitis-pigmentosa","display_name":"retinitis pigmentosa","score":0.8429999947547913},{"id":"https://openalex.org/keywords/retinal-neurons","display_name":"retinal neurons","score":0.5429999828338623},{"id":"https://openalex.org/keywords/peripheral-retina","display_name":"peripheral retina","score":0.414000004529953},{"id":"https://openalex.org/keywords/central-retina","display_name":"central retina","score":0.9570000171661377}],"concepts":[{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.9124228954315186},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.9118152260780334},{"id":"https://openalex.org/C159431405","wikidata":"https://www.wikidata.org/wiki/Q5513327","display_name":"GFAP stain","level":4,"score":0.7658728957176208},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.691365122795105},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.614474892616272},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6071569323539734},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.5509055852890015},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5091537833213806},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4980127811431885},{"id":"https://openalex.org/C164659718","wikidata":"https://www.wikidata.org/wiki/Q5159266","display_name":"Conditional gene knockout","level":4,"score":0.46137842535972595},{"id":"https://openalex.org/C2780884517","wikidata":"https://www.wikidata.org/wiki/Q177105","display_name":"Neuroglia","level":3,"score":0.4108927249908447},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4003055989742279},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24349799752235413},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.21974030137062073},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18894049525260925},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16655752062797546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12948545813560486},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.1033196747303009},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06708869338035583},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06286460161209106},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.049947500228881836},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000076202","descriptor_name":"c-Mer Tyrosine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005904","descriptor_name":"Glial Fibrillary Acidic Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012174","descriptor_name":"Retinitis Pigmentosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020794","descriptor_name":"Receptor Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:20497693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20497693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:2423906174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20497693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3150619824","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/85656X/201007/33684890.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541197","display_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W59369753","https://openalex.org/W2060637975","https://openalex.org/W1979474933","https://openalex.org/W2073330897","https://openalex.org/W112521617","https://openalex.org/W2170595418","https://openalex.org/W3016011852","https://openalex.org/W7097924471","https://openalex.org/W1984543781","https://openalex.org/W2022573553"],"abstract_inverted_index":{"BACKGROUND:":[0],"M\u00fcller":[1,236,258],"cells":[2,237,259],"in":[3,22,32,72,115,161,210,235,245,251,257,284,298,313],"the":[4,25,39,49,62,68,73,111,116,162,174,183,201,205,211,214,225,246,252,267,285,291,299,307,314],"mammalian":[5],"retina":[6,74,120,166,185,206,227,248],"normally":[7],"express":[8],"low":[9],"levels":[10],"of":[11,27,34,38,42,52,56,65,70,75,82,113,121,130,159,167,186,204,233,238,269,274,293,302,309],"glial":[12],"fibrillary":[13],"acidic":[14],"protein":[15],"(GFAP);":[16],"however,":[17],"its":[18],"expression":[19,33,69,112,158,191,216,232,256,273],"is":[20,36,46],"upregulated":[21,193,218],"response":[23,265],"to":[24,60,93,109,173,261,266,279,306],"loss":[26,268,292],"retinal":[28,43,175,270,294],"neurons.":[29,271],"The":[30,54,157],"change":[31],"GFAP":[35,71,114,160,190,197,215,222,234,255,275],"one":[37],"earliest":[40],"indicators":[41],"damage":[44],"and":[45,67,96,118,124,152,164,178,196,221,249],"correlated":[47],"with":[48],"time":[50,63],"course":[51,64],"disease.":[53],"aim":[55],"this":[57],"study":[58,288],"was":[59,107,171,192,217],"investigate":[61],"degeneration":[66],"mer":[76,84,122,187,239],"knockout":[77,85,123,188,240],"mice.":[78],"METHODS:":[79],"A":[80],"total":[81],"30":[83],"mice,":[86,189],"aged":[87],"from":[88],"15":[89,131],"-":[90],"20":[91,134],"days":[92,132,135],"1":[94,153],"year":[95],"32":[97],"age-matched":[98],"wild":[99,168],"type":[100,169],"mice":[101,126,170,241],"as":[102],"controls":[103],"were":[104],"tested.":[105],"Immunohistochemistry":[106],"used":[108],"show":[110],"central":[117,163,184,253],"peripheral":[119,165,212,247],"control":[125],"at":[127,194,207,219,243],"postnatal":[128],"age":[129],"(P15d),":[133],"(P20d),":[136],"4":[137],"weeks":[138,141,144],"(P4w),":[139],"6":[140,149],"(P6w),":[142],"8":[143],"(P8w),":[145],"3":[146],"months":[147,150],"(P3m),":[148],"(P6m)":[151],"years":[154],"(P1y).":[155],"RESULTS:":[156],"limited":[172],"ganglion":[176],"cell":[177],"nerve":[179],"fiber":[180],"layers.":[181],"In":[182],"P4w":[195,250],"immunolabelling":[198,223],"penetrates":[199,224],"across":[200],"entire":[202,226],"thickness":[203],"P8w;":[208],"whereas":[209],"retina,":[213],"P20d":[220,244],"after":[228],"P4w.":[229],"CONCLUSIONS:":[230],"Increased":[231,272],"occur":[242,277],"retina.":[254,286,315],"appears":[260],"be":[262],"a":[263],"secondary":[264],"may":[276,296],"prior":[278,305],"any":[280,310],"detectable":[281],"morphological":[282,311],"changes":[283,312],"This":[287],"suggests":[289],"that":[290],"neurons":[295],"begin":[297],"early":[300],"stages":[301],"retinitis":[303],"pigmentosa,":[304],"discovery":[308]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
