{"id":"https://openalex.org/W2423858046","doi":null,"title":"D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1.","display_name":"D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1.","publication_year":1991,"publication_date":"1991-03-01","ids":{"openalex":"https://openalex.org/W2423858046","mag":"2423858046","pmid":"https://pubmed.ncbi.nlm.nih.gov/2011398"},"language":"en","primary_location":{"id":"pmid:2011398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2011398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111934450","display_name":"G. Alistair Lammie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G A Lammie","raw_affiliation_strings":["Imperial Cancer Research Fund Laboratories, St Bartholomew's Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Cancer Research Fund Laboratories, St Bartholomew's Hospital, London, UK","institution_ids":["https://openalex.org/I1307195382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108215865","display_name":"Vera Fantl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Fantl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091503173","display_name":"Ed Schuuring","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Schuuring","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021987710","display_name":"Sharon Brookes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Brookes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023741222","display_name":"Rob J. A. M. Michalides","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Michalides","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037675485","display_name":"Clive Dickson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Dickson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049232174","display_name":"Andrew Arnold","orcid":"https://orcid.org/0000-0002-8821-8527","observed_orcids":["https://orcid.org/0000-0002-8821-8527"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Arnold","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091852349","display_name":"Greg B. Peters","orcid":"https://orcid.org/0000-0001-7414-1082","observed_orcids":["https://orcid.org/0000-0001-7414-1082"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Peters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":19.4162,"has_fulltext":false,"cited_by_count":367,"citation_normalized_percentile":{"value":0.99677041,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"6","issue":"3","first_page":"439","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.3562000095844269,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.3562000095844269,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.2142000049352646,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.17100000381469727,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosome-11q13","display_name":"chromosome 11q13","score":0.9190000295639038},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.824999988079071},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.7990000247955322},{"id":"https://openalex.org/keywords/bcl-1","display_name":"BCL1","score":0.8090000152587891},{"id":"https://openalex.org/keywords/int-2","display_name":"int-2","score":0.9309999942779541},{"id":"https://openalex.org/keywords/fgf4","display_name":"FGF4","score":0.996999979019165},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.7910000085830688},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.972000002861023},{"id":"https://openalex.org/keywords/parathyroid-adenoma","display_name":"parathyroid adenoma","score":0.7850000262260437},{"id":"https://openalex.org/keywords/translocation-breakpoints","display_name":"translocation breakpoints","score":0.6510000228881836},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.574999988079071},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8946505784988403},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.7863669395446777},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.6976186037063599},{"id":"https://openalex.org/C206936463","wikidata":"https://www.wikidata.org/wiki/Q634179","display_name":"Breakpoint","level":4,"score":0.6212335228919983},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5062581896781921},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49691298604011536},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.49430084228515625},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48367151618003845},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4794570207595825},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.46902504563331604},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45241376757621765},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3172368109226227},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2286970615386963}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002880","descriptor_name":"Chromosomes, Human, Pair 11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004587","descriptor_name":"Electrophoresis, Agar Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051518","descriptor_name":"Fibroblast Growth Factor 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2011398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2011398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:2423858046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2011398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4244266156","https://openalex.org/W2470015447","https://openalex.org/W2054205514","https://openalex.org/W45999627","https://openalex.org/W2417409990","https://openalex.org/W2337510086","https://openalex.org/W1984690136","https://openalex.org/W1986591351","https://openalex.org/W2062181868","https://openalex.org/W2064362422"],"abstract_inverted_index":{"Approximately":[0],"15":[1],"to":[2],"20%":[3],"of":[4,13,17,24,30,69,90,119,151],"primary":[5,92],"breast":[6,76],"cancers":[7],"and":[8,20,47,85,124,153,173],"an":[9],"even":[10],"higher":[11],"proportion":[12],"squamous":[14],"cell":[15,154],"carcinomas":[16],"the":[18,38,43,67,99,105,116,120,137,158,166],"head":[19],"neck":[21],"show":[22,58],"amplification":[23],"DNA":[25],"markers":[26],"on":[27,115,169],"band":[28],"q13":[29],"human":[31],"chromosome":[32],"11.":[33],"However,":[34],"known":[35],"genes":[36],"within":[37],"amplified":[39,74,100,171],"region,":[40],"such":[41],"as":[42,122],"FGF-related":[44],"oncogenes":[45],"INT-2":[46,84],"HST-1,":[48],"are":[49],"very":[50],"rarely":[51],"expressed":[52],"in":[53,66,75,87,97,148,156],"these":[54],"tumors.":[55],"Here":[56],"we":[57],"that":[59,112,129],"another":[60],"candidate":[61],"oncogene,":[62],"designated":[63],"D11S287,":[64],"implicated":[65],"pathogenesis":[68],"parathyroid":[70],"adenomas,":[71],"is":[72,80,114,131,161],"also":[73,175],"cancers.":[77],"Significantly,":[78],"it":[79,163],"consistently":[81],"coamplified":[82],"with":[83],"HST-1":[86],"36":[88],"out":[89],"202":[91],"tumors,":[93],"including":[94],"one":[95],"case":[96],"which":[98,157],"unit":[101],"did":[102],"not":[103],"encompass":[104],"translocation":[106],"breakpoint":[107,121],"marker":[108],"BCL-1.":[109],"This":[110],"implies":[111],"D11S287":[113,130,141],"same":[117],"side":[118],"INT-2,":[123],"pulsed-field":[125],"gel":[126],"electrophoresis":[127],"indicates":[128],"less":[132],"than":[133],"250":[134],"kb":[135],"from":[136],"BCL-1":[138,179],"marker.":[139],"Since":[140],"RNA":[142],"was":[143],"present":[144],"at":[145],"elevated":[146],"levels":[147],"a":[149],"group":[150],"tumors":[152],"lines":[155],"11q13":[159],"region":[160],"amplified,":[162],"may":[164],"be":[165,176],"key":[167],"oncogene":[168],"this":[170],"unit,":[172],"could":[174],"activated":[177],"by":[178],"translocations.":[180]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}