{"id":"https://openalex.org/W2423618261","doi":null,"title":"New concepts regarding micro/nanopharmaceutical polymer systems with applications in ophthalmology and neurosciences","display_name":"New concepts regarding micro/nanopharmaceutical polymer systems with applications in ophthalmology and neurosciences","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W2423618261","mag":"2423618261"},"language":"en","primary_location":{"id":"pmh:oai:ojs2.journals.lapub.co.uk:article/595","doi":null,"is_oa":true,"landing_page_url":"https://journals.lapub.co.uk/index.php/roneurosurgery/article/view/595","pdf_url":"https://journals.lapub.co.uk/index.php/roneurosurgery/article/download/595/477","source":{"id":"https://openalex.org/S2739249004","display_name":"Romanian Neurosurgery","issn_l":"1220-8841","issn":["1220-8841","2344-4959"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311679","host_organization_name":"London Academic Publishing","host_organization_lineage":["https://openalex.org/P4310311679"],"host_organization_lineage_names":["London Academic Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1220-8841","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.lapub.co.uk/index.php/roneurosurgery/article/download/595/477","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058415431","display_name":"Fotios A. Gardikiotis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fotios A. Gardikiotis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001661064","display_name":"Catalina Anisoara Peptu","orcid":"https://orcid.org/0000-0002-1682-0682","observed_orcids":["https://orcid.org/0000-0002-1682-0682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catalina A. Peptu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031101512","display_name":"Marcel Popa","orcid":"https://orcid.org/0000-0003-4929-0830","observed_orcids":["https://orcid.org/0000-0003-4929-0830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcel Popa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110415973","display_name":"D\u0103nu\u021b Costin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danut Costin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2123,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45232816,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polymeric-nanoparticles","display_name":"polymeric nanoparticles","score":0.7639999985694885},{"id":"https://openalex.org/keywords/micro-nanoparticles","display_name":"micro- and nanoparticles","score":0.7820000052452087},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ocular-drug-delivery","display_name":"ocular drug delivery","score":0.8790000081062317},{"id":"https://openalex.org/keywords/neurosurgery","display_name":"neurosurgery","score":0.7310000061988831},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.8970000147819519},{"id":"https://openalex.org/keywords/retinal-disease","display_name":"retinal disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/optic-nerve-diseases","display_name":"optic nerve diseases","score":0.9549999833106995},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7770000100135803},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.4819999933242798},{"id":"https://openalex.org/keywords/drug-bioavailability","display_name":"drug bioavailability","score":0.7049999833106995},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.609000027179718},{"id":"https://openalex.org/keywords/nanoparticle-formulation","display_name":"nanoparticle formulation","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3897624611854553},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.36997729539871216},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.348812997341156},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3476599454879761},{"id":"https://openalex.org/C126348684","wikidata":"https://www.wikidata.org/wiki/Q3456979","display_name":"Polymer science","level":1,"score":0.33693695068359375},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.334102988243103},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3095448613166809},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2678128480911255}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ojs2.journals.lapub.co.uk:article/595","doi":null,"is_oa":true,"landing_page_url":"https://journals.lapub.co.uk/index.php/roneurosurgery/article/view/595","pdf_url":"https://journals.lapub.co.uk/index.php/roneurosurgery/article/download/595/477","source":{"id":"https://openalex.org/S2739249004","display_name":"Romanian Neurosurgery","issn_l":"1220-8841","issn":["1220-8841","2344-4959"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311679","host_organization_name":"London Academic Publishing","host_organization_lineage":["https://openalex.org/P4310311679"],"host_organization_lineage_names":["London Academic Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1220-8841","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:1ee0d1f27d134d54886c1b13048d2af8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1ee0d1f27d134d54886c1b13048d2af8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Romanian Neurosurgery, Vol 18, Iss 3 (2011)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:ojs2.journals.lapub.co.uk:article/595","doi":null,"is_oa":true,"landing_page_url":"https://journals.lapub.co.uk/index.php/roneurosurgery/article/view/595","pdf_url":"https://journals.lapub.co.uk/index.php/roneurosurgery/article/download/595/477","source":{"id":"https://openalex.org/S2739249004","display_name":"Romanian Neurosurgery","issn_l":"1220-8841","issn":["1220-8841","2344-4959"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311679","host_organization_name":"London Academic Publishing","host_organization_lineage":["https://openalex.org/P4310311679"],"host_organization_lineage_names":["London Academic Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1220-8841","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2423618261.pdf","grobid_xml":"https://content.openalex.org/works/W2423618261.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W148312232","https://openalex.org/W639307252","https://openalex.org/W1579977115","https://openalex.org/W1984459713","https://openalex.org/W1990842129","https://openalex.org/W2026408068","https://openalex.org/W2026419772","https://openalex.org/W2026741029","https://openalex.org/W2030335869","https://openalex.org/W2042280116","https://openalex.org/W2062487182","https://openalex.org/W2067947451","https://openalex.org/W2070790160","https://openalex.org/W2087175486","https://openalex.org/W2094002712","https://openalex.org/W2102449174","https://openalex.org/W2163618108","https://openalex.org/W2194135471","https://openalex.org/W4255378812"],"related_works":["https://openalex.org/W4313421548","https://openalex.org/W2110373623","https://openalex.org/W2994935843","https://openalex.org/W2767308976","https://openalex.org/W7216578415","https://openalex.org/W2423521974","https://openalex.org/W2783269376","https://openalex.org/W1994442938","https://openalex.org/W4412956960","https://openalex.org/W2996028494"],"abstract_inverted_index":{"Particulate":[0],"systems":[1,41,125],"like":[2],"micro/nanoparticles":[3,87],"have":[4,80],"been":[5,81],"used":[6,82],"as":[7],"a":[8,68],"physical":[9],"approach":[10],"to":[11,58,73,92,127],"modify":[12],"the":[13,27,32,39,43,46,50,56,59,65,74,84,134,137,159,167],"pharmacokinetic":[14],"and":[15,30,62,70,155,163,178,185],"pharmacodynamic":[16],"properties":[17],"of":[18,21,38,45,55,64,76,86,102,116,136,144,152,161,166,171],"various":[19,142],"types":[20],"drug":[22,28,47,57,66,89],"molecules":[23],"increasing":[24],"this":[25],"way":[26],"bioavailability":[29],"avoiding":[31],"toxic":[33],"level.":[34],"The":[35],"major":[36],"advantages":[37,108],"particulate":[40,124],"include":[42],"protection":[44],"entity":[48],"in":[49,83,158,174,183],"systemic":[51],"circulation,":[52],"restriction":[53],"access":[54],"chosen":[60],"sites":[61],"delivery":[63,90],"at":[67],"controlled":[69],"sustained":[71],"rate":[72],"site":[75],"action.":[77],"Various":[78],"materials":[79,103],"formulation":[85,146],"for":[88,113],"research":[91],"increase":[93],"therapeutic":[94],"benefit,":[95],"while":[96],"minimizing":[97],"side":[98],"effects.":[99],"Each":[100],"class":[101],"(metals,":[104],"lipids,":[105],"polymers)":[106],"presents":[107],"which":[109],"make":[110],"them":[111],"suitable":[112],"different":[114],"classes":[115],"applications.":[117],"This":[118],"paper":[119],"focuses":[120],"mainly":[121],"on":[122],"polymer":[123,172],"due":[126],"their":[128,153,156],"large":[129],"applicability":[130],"area":[131],"given":[132],"by":[133],"diversity":[135],"polymers":[138],"properties.":[139],"We":[140],"review":[141],"aspects":[143],"micro/nanoparticle":[145],"including":[147],"preparation,":[148],"release":[149],"mechanisms,":[150],"effect":[151],"characteristics":[154],"applications":[157,170],"field":[160],"ophthalmology":[162],"neurosciences.":[164],"Some":[165],"most":[168],"interesting":[169],"micro/nanoparticulates":[173],"glaucoma,":[175],"retinal":[176],"disorders":[177],"optical":[179],"nerve":[180],"disorders,":[181],"respectivelly":[182],"neurology":[184],"neurosurgery":[186],"are":[187],"presented.":[188]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}