{"id":"https://openalex.org/W242197823","doi":null,"title":"Epidermal growth factor receptor gene amplification in atypical adenomatous hyperplasia of the lung.","display_name":"Epidermal growth factor receptor gene amplification in atypical adenomatous hyperplasia of the lung.","publication_year":2010,"publication_date":"2010-05-16","ids":{"openalex":"https://openalex.org/W242197823","mag":"242197823","pmid":"https://pubmed.ncbi.nlm.nih.gov/20589169"},"language":"en","primary_location":{"id":"pmid:20589169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20589169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2892406","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047022773","display_name":"Maria G. McIntire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria G McIntire","raw_affiliation_strings":["Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010234110","display_name":"Sandro Santagata","orcid":"https://orcid.org/0000-0002-7528-9668","observed_orcids":["https://orcid.org/0000-0002-7528-9668"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandro Santagata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010270402","display_name":"Keith Lloyd Ligon","orcid":"https://orcid.org/0000-0002-7733-600X","observed_orcids":["https://orcid.org/0000-0002-7733-600X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith Ligon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089159833","display_name":"Lucian R. Chirieac","orcid":"https://orcid.org/0000-0002-4383-6938","observed_orcids":["https://orcid.org/0000-0002-4383-6938"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucian R Chirieac","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7368,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.74370624,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"3","first_page":"309","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.984000027179718},{"id":"https://openalex.org/keywords/egfr-amplification","display_name":"EGFR amplification","score":0.9679999947547913},{"id":"https://openalex.org/keywords/atypical-adenomatous-hyperplasia","display_name":"atypical adenomatous hyperplasia","score":0.9459999799728394},{"id":"https://openalex.org/keywords/bronchioloalveolar-carcinoma","display_name":"bronchioloalveolar carcinoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8299999833106995},{"id":"https://openalex.org/keywords/gene-copy-number-gain","display_name":"gene copy number gain","score":0.7329999804496765},{"id":"https://openalex.org/keywords/lung-carcinogenesis","display_name":"lung carcinogenesis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/precancerous-lesions","display_name":"precancerous lesions","score":0.6880000233650208},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2777150480","wikidata":"https://www.wikidata.org/wiki/Q16642630","display_name":"Atypical adenomatous hyperplasia","level":4,"score":0.8429968357086182},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.7994062304496765},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5791435837745667},{"id":"https://openalex.org/C121313828","wikidata":"https://www.wikidata.org/wiki/Q17861998","display_name":"CISH","level":5,"score":0.56666499376297},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5512795448303223},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5487445592880249},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5286144614219666},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.4831063747406006},{"id":"https://openalex.org/C2776643354","wikidata":"https://www.wikidata.org/wiki/Q5113886","display_name":"Chromogenic in situ hybridization","level":5,"score":0.47167903184890747},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.46785953640937805},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.4424591064453125},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4412887692451477},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4249823987483978},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4201315939426422},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.4100024104118347},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.38746872544288635},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27227672934532166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2558571994304657},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24290946125984192},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.22441262006759644},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21522265672683716},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.16773420572280884},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1516183316707611},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1315026879310608},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmid:20589169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20589169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2892406","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2892406","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmh:oai:dash.harvard.edu:1/37372828","doi":null,"is_oa":false,"landing_page_url":"https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372828","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"mag:242197823","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20589169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2892406","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2892406","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7400000095367432,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4752445381","display_name":"Dana-Farber/Harvard Cancer Center SPORE in Lung Cancer","funder_award_id":"5p50ca090578-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5758242661","display_name":"SPORE in Lung Cancer","funder_award_id":"P20CA090578","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W1485587458"],"related_works":["https://openalex.org/W2092669109","https://openalex.org/W2021053102","https://openalex.org/W2396837835","https://openalex.org/W764002562","https://openalex.org/W2405152131","https://openalex.org/W2003658509","https://openalex.org/W2409459894","https://openalex.org/W2405569611","https://openalex.org/W2045799337","https://openalex.org/W2087764235","https://openalex.org/W2167789193","https://openalex.org/W2342846352","https://openalex.org/W2036170839","https://openalex.org/W2211100168","https://openalex.org/W2099203056","https://openalex.org/W3028440111","https://openalex.org/W3136565915","https://openalex.org/W2901521863","https://openalex.org/W2358009584","https://openalex.org/W1972380802"],"abstract_inverted_index":{"Atypical":[0],"adenomatous":[1],"hyperplasia":[2],"(AAH)":[3],"is":[4,32,76,110],"postulated":[5],"to":[6,221,250,293,324],"be":[7,311],"the":[8,24,27,44,52,66,102,117,160,246,263,282,329],"earliest":[9],"morphologic":[10],"precursor":[11],"lesion":[12],"in":[13,35,51,92,97,108,123,130,143,195,199,228,274,289,298,315],"lung":[14,38,124,299,316],"carcinogenesis.":[15],"The":[16,175],"epidermal":[17],"growth":[18],"factor":[19],"receptor":[20],"(EGFR),":[21],"one":[22],"of":[23,26,30,43,69,71,79,166,180,201,204,230,233,262,277,284,331],"members":[25],"Erb-2":[28],"family":[29],"receptors,":[31],"commonly":[33],"expressed":[34],"non-small":[36],"cell":[37],"carcinoma":[39,99],"(NSCLC).":[40],"A":[41,162],"subset":[42],"patients":[45],"with":[46,216,260,321],"NSCLC":[47],"has":[48],"molecular":[49],"abnormalities":[50,288,309],"EGFR":[53,86,103,118,135,155,188,210,239,270,285,306],"gene,":[54],"including":[55],"missense":[56],"mutations":[57,87],"and":[58,65,94,128,154,295,327],"deletions":[59],"and/or":[60],"abnormal":[61,269],"gene":[62,104,119,136,271,286,307],"copy":[63,105,120,137,196,272,287,308],"numbers,":[64],"relative":[67],"importance":[68],"each":[70],"these":[72],"for":[73],"patient":[74],"outcome":[75],"an":[77,268,312],"area":[78],"great":[80],"interest.":[81],"Recent":[82],"reports":[83],"show":[84],"that":[85,178,304],"are":[88,95,319],"rare":[89,96],"or":[90],"absent":[91],"AAH":[93,109,205,290],"bronchioloalveolar":[98],"(BAC).":[100],"However,":[101],"number":[106,121,138],"status":[107,122],"unknown.":[111],"In":[112,226,245,279],"this":[113],"study,":[114],"we":[115],"examined":[116],"adenocarcinomas,":[125],"synchronous":[126],"AAH,":[127],"BAC":[129,234,294],"surgical":[131],"pathology":[132],"resection":[133],"specimens.":[134],"was":[139,169],"analyzed":[140],"by":[141,159],"chromogenic":[142],"situ":[144],"hybridization":[145],"(CISH)":[146],"using":[147],"formalin":[148],"fixed":[149],"paraffin":[150],"embedded":[151],"tissue":[152],"sections":[153],"probes":[156],"as":[157,171],"recommended":[158],"manufacturer.":[161],"known":[163],"positive":[164,173,255],"case":[165],"high-grade":[167],"glioma":[168],"used":[170],"a":[172,193],"control.":[174],"results":[176],"indicate":[177],"four":[179,200],"eight":[181],"adenocarcinomas":[182],"(50%)":[183],"had":[184],"more":[185,207,236],"than":[186,208,237,297],"five":[187,229],"signals":[189,211,223,240,256],"per":[190,212,224,241],"nucleus,":[191],"suggesting":[192],"gain":[194,273],"number.":[197],"Interestingly,":[198],"nine":[202],"cases":[203,232,248,276],"(44.4%)":[206],"three":[209,238,251],"nucleus":[213,242],"were":[214,243,257],"noted,":[215],"scattered":[217],"cells":[218],"showing":[219],"up":[220],"6":[222],"nucleus.":[225],"addition,":[227],"12":[231],"(42%),":[235],"noted.":[244],"remaining":[247],"two":[249],"intranuclear":[252],"dot-like":[253],"peroxidase":[254],"present":[258],"consistent":[259],"non-amplification":[261],"gene.":[264],"Our":[265],"study":[266],"reveals":[267],"several":[275],"AAH.":[278],"our":[280],"cohort,":[281],"rate":[283],"appears":[291],"similar":[292],"lower":[296],"adenocarcinomas.":[300],"These":[301],"findings":[302],"suggest":[303],"although":[305],"may":[310],"early":[313],"event":[314],"carcinogenesis,":[317],"they":[318],"associated":[320],"tumor":[322,332],"progression":[323],"invasive":[325],"cancer":[326],"highlight":[328],"complexity":[330],"morphogenesis.":[333]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
