{"id":"https://openalex.org/W2420101616","doi":null,"title":"[Importance of the new triazoles in antifungal therapy].","display_name":"[Importance of the new triazoles in antifungal therapy].","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2420101616","mag":"2420101616","pmid":"https://pubmed.ncbi.nlm.nih.gov/1652677"},"language":"tr","primary_location":{"id":"pmid:1652677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1652677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mikrobiyoloji bulteni","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079812558","display_name":"Beng\u00fcl Durmaz","orcid":"https://orcid.org/0000-0002-9093-7440","observed_orcids":["https://orcid.org/0000-0002-9093-7440"]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"B Durmaz","raw_affiliation_strings":["In\u00f6n\u00fc Universitesi, Tip Fak\u00fcltesi, Mikrobiyoloji Anabilim Dali, Malatya"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"In\u00f6n\u00fc Universitesi, Tip Fak\u00fcltesi, Mikrobiyoloji Anabilim Dali, Malatya","institution_ids":["https://openalex.org/I20126385"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079812558"],"corresponding_institution_ids":["https://openalex.org/I20126385"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"1","first_page":"118","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11900","display_name":"Fungal Plant Pathogen Control","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triazoles","display_name":"triazoles","score":0.9670000076293945},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.8830000162124634},{"id":"https://openalex.org/keywords/itraconazole","display_name":"itraconazole","score":0.9750000238418579},{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":1.0},{"id":"https://openalex.org/keywords/polyene-antibiotics","display_name":"polyene antibiotics","score":0.871999979019165},{"id":"https://openalex.org/keywords/azole-antifungals","display_name":"azole antifungals","score":0.8159999847412109},{"id":"https://openalex.org/keywords/fungal-plasma-membrane","display_name":"fungal plasma membrane","score":0.8569999933242798},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.8500000238418579},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C2777071850","wikidata":"https://www.wikidata.org/wiki/Q411229","display_name":"Itraconazole","level":3,"score":0.8582205772399902},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.8518966436386108},{"id":"https://openalex.org/C2780315139","wikidata":"https://www.wikidata.org/wiki/Q419639","display_name":"Azole","level":3,"score":0.7952608466148376},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.7374318838119507},{"id":"https://openalex.org/C2779594873","wikidata":"https://www.wikidata.org/wiki/Q2519471","display_name":"Polyene","level":2,"score":0.659974217414856},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5079601407051086},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4517270624637604},{"id":"https://openalex.org/C2909919671","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal drugs","level":3,"score":0.4398791790008545},{"id":"https://openalex.org/C2777907353","wikidata":"https://www.wikidata.org/wiki/Q903341","display_name":"Triazole","level":2,"score":0.4246682822704315},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40223458409309387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21289944648742676},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.17710453271865845},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13037145137786865}],"mesh":[{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007654","descriptor_name":"Ketoconazole","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007654","descriptor_name":"Ketoconazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009181","descriptor_name":"Mycoses","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015725","descriptor_name":"Fluconazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017964","descriptor_name":"Itraconazole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1652677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1652677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mikrobiyoloji bulteni","raw_type":"English Abstract"},{"id":"mag:2420101616","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1652677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1971219620","https://openalex.org/W1916615072","https://openalex.org/W2080427551","https://openalex.org/W2027954585","https://openalex.org/W2338395605","https://openalex.org/W2037893855","https://openalex.org/W3208778405","https://openalex.org/W4211102281","https://openalex.org/W2144297397","https://openalex.org/W2018904144"],"abstract_inverted_index":{"Polyene":[0],"antibiotics":[1],"and":[2,27,48],"azole":[3],"compounds":[4],"are":[5],"two":[6,34,43],"major":[7],"groups":[8,35],"of":[9,20,25,29,32,42],"clinically":[10],"important":[11],"antifungal":[12],"drugs.":[13],"Both":[14],"interact":[15],"with":[16],"the":[17,30,40],"plasma":[18],"membrane":[19],"susceptible":[21],"fungi.":[22],"The":[23],"mechanisms":[24],"action":[26],"toxicities":[28],"members":[31],"these":[33],"have":[36],"been":[37,51],"reviewed.":[38],"Also":[39],"importance":[41],"new":[44],"triazoles":[45],"compounds,":[46],"itraconazole":[47],"fluconazole,":[49],"has":[50],"emphasised.":[52]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}