{"id":"https://openalex.org/W2420056077","doi":null,"title":"Systemic administration of recombinant human interleukin-2 in mice.","display_name":"Systemic administration of recombinant human interleukin-2 in mice.","publication_year":1984,"publication_date":"1984-10-01","ids":{"openalex":"https://openalex.org/W2420056077","mag":"2420056077","pmid":"https://pubmed.ncbi.nlm.nih.gov/6334141"},"language":"en","primary_location":{"id":"pmid:6334141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6334141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological response modifiers","raw_type":"Comparative Study"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104109531","display_name":"Alfred E. Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A E Chang","raw_affiliation_strings":["National Cancer Institute United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute United States","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108509880","display_name":"Cornelia L. Hyatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C L Hyatt","raw_affiliation_strings":["National Cancer Institute United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute United States","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072133376","display_name":"Steven A. Rosenberg","orcid":"https://orcid.org/0000-0002-8939-8910","observed_orcids":["https://orcid.org/0000-0002-8939-8910"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S A Rosenberg","raw_affiliation_strings":["National Cancer Institute United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute United States","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":3.6923,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.94360126,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"3","issue":"5","first_page":"561","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.8281000256538391,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.8281000256538391,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.04639999940991402,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-human-interleukin-2","display_name":"recombinant human interleukin-2","score":0.9200000166893005},{"id":"https://openalex.org/keywords/systemic-administration","display_name":"systemic administration","score":0.7379999756813049},{"id":"https://openalex.org/keywords/route-of-administration","display_name":"route of administration","score":0.8830000162124634},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.8870000243186951},{"id":"https://openalex.org/keywords/circulating-half-life","display_name":"serum half-life","score":0.9589999914169312},{"id":"https://openalex.org/keywords/continuous-infusion","display_name":"continuous infusion","score":0.7409999966621399},{"id":"https://openalex.org/keywords/osmotic-pump","display_name":"osmotic pump","score":0.8289999961853027},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.7789999842643738},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.7120000123977661},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6499999761581421},{"id":"https://openalex.org/keywords/lymphokine-activated-killer-cells","display_name":"lymphokine-activated killer cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/peritoneal-exudate","display_name":"peritoneal exudate","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.656000018119812},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.8098191022872925},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.7494174242019653},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6416394710540771},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6208596229553223},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.5673273801803589},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.505673885345459},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4514075219631195},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4474864602088928},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4401931166648865},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.4321144223213196},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.4278136193752289},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4175572097301483},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.30452239513397217},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2804288864135742},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26859503984451294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21098372340202332},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07891547679901123},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6334141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6334141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biological response modifiers","raw_type":"Comparative Study"},{"id":"mag:2420056077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6334141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6899999976158142,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1643040145","https://openalex.org/W2062460007","https://openalex.org/W1593923919","https://openalex.org/W2095636772","https://openalex.org/W2405621947","https://openalex.org/W2066564941","https://openalex.org/W1976212966","https://openalex.org/W4391198282","https://openalex.org/W2412913080","https://openalex.org/W2003506995"],"abstract_inverted_index":{"The":[0,47,171,196],"production":[1],"of":[2,14,19,32,34,36,44,93,135,141,146,154,174,186,199,219],"recombinant":[3],"human":[4],"interleukin-2":[5],"(RIL-2)":[6],"in":[7,16,22,38,69,106,160,181,183,190,201,216],"large":[8],"amounts":[9],"has":[10,213],"made":[11],"possible":[12],"studies":[13],"the":[15,23,42,182,191,202,217],"vivo":[17,184],"effects":[18],"this":[20,45],"lymphokine":[21],"normal":[24,203],"murine":[25,204],"host.":[26],"We":[27],"have":[28],"studied":[29],"a":[30,151,177],"variety":[31],"routes":[33],"administration":[35,52,67,173,198],"RIL-2":[37,70,94,107,122,163,175,200],"mice":[39,161],"to":[40,77,114,150],"maximize":[41],"bioavailability":[43],"lymphokine.":[46],"serum":[48,71,108],"half-life":[49],"after":[50],"intravenous":[51],"was":[53,84,95,158],"1.6":[54],"+/-":[55,59],"0.3":[56],"min":[57],"(mean":[58],"SEM,":[60],"n":[61],"=":[62],"3).":[63],"Intraperitoneal":[64],"and":[65,83,104,193,212,221],"subcutaneous":[66],"resulted":[68,105,180],"levels":[72,109],"greater":[73,110,118],"than":[74,111,119],"or":[75,102,112],"equal":[76,113],"10":[78],"units/ml":[79,116],"for":[80,88,117,128,168],"3-5":[81],"h,":[82],"prolonged":[85],"by":[86,139],"gelatin":[87],"7-11":[89],"h.":[90],"Continuous":[91],"infusion":[92],"accomplished":[96],"with":[97],"osmotic":[98],"pumps":[99],"placed":[100],"intraperitoneally":[101,124,164],"subcutaneously,":[103],"8":[115],"4":[120],"days.":[121,170],"given":[123],"three":[125,165,207],"times":[126,166],"daily":[127,167],"3":[129,169],"days":[130],"enhanced":[131],"natural":[132],"killer":[133,188],"activity":[134],"splenocytes":[136],"as":[137],"measured":[138],"lysis":[140],"YAC":[142],"cells.":[143],"Specific":[144],"augmentation":[145],"C57BL/6":[147],"splenocyte":[148],"cytotoxicity":[149],"secondary":[152],"challenge":[153],"irradiated":[155],"allogeneic":[156],"P815":[157],"found":[159],"receiving":[162],"continuous":[172],"over":[176],"4-day":[178],"period":[179],"generation":[185],"lymphokine-activated":[187],"cells":[189],"spleen":[192],"peritoneal":[194],"exudate.":[195],"exogenous":[197],"host":[205],"enhances":[206],"different":[208],"cell-mediated":[209],"cytotoxic":[210],"mechanisms":[211],"potential":[214],"applications":[215],"treatment":[218],"tumors":[220],"immunodeficient":[222],"conditions.":[223]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}