{"id":"https://openalex.org/W2420005398","doi":"https://doi.org/10.1002/stem.2413","title":"Immunomodulatory Factors Control the Fate of Melanoma Tumor Initiating Cells","display_name":"Immunomodulatory Factors Control the Fate of Melanoma Tumor Initiating Cells","publication_year":2016,"publication_date":"2016-06-14","ids":{"openalex":"https://openalex.org/W2420005398","doi":"https://doi.org/10.1002/stem.2413","mag":"2420005398","pmid":"https://pubmed.ncbi.nlm.nih.gov/27301067"},"language":"en","primary_location":{"id":"doi:10.1002/stem.2413","doi":"https://doi.org/10.1002/stem.2413","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.2413","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069493976","display_name":"Alessandra Tuccitto","orcid":"https://orcid.org/0000-0002-5186-7777","observed_orcids":["https://orcid.org/0000-0002-5186-7777"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Tuccitto","raw_affiliation_strings":["Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]},{"raw_affiliation_string":"Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053093525","display_name":"Marcella Tazzari","orcid":"https://orcid.org/0000-0002-8112-1773","observed_orcids":["https://orcid.org/0000-0002-8112-1773"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marcella Tazzari","raw_affiliation_strings":["Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]},{"raw_affiliation_string":"Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009410529","display_name":"Valeria Beretta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valeria Beretta","raw_affiliation_strings":["Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]},{"raw_affiliation_string":"Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112706402","display_name":"Francesca Rini","orcid":"https://orcid.org/0000-0001-8516-9232","observed_orcids":["https://orcid.org/0000-0001-8516-9232"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Rini","raw_affiliation_strings":["Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]},{"raw_affiliation_string":"Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103245275","display_name":"Cl\u00e1udia Miranda","orcid":"https://orcid.org/0000-0003-4147-1012","observed_orcids":["https://orcid.org/0000-0003-4147-1012"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Miranda","raw_affiliation_strings":["Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","Molecular Mechanism Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]},{"raw_affiliation_string":"Molecular Mechanism Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005945571","display_name":"Angela Greco","orcid":"https://orcid.org/0000-0003-2994-0349","observed_orcids":["https://orcid.org/0000-0003-2994-0349"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angela Greco","raw_affiliation_strings":["Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","Molecular Mechanism Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]},{"raw_affiliation_string":"Molecular Mechanism Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087113555","display_name":"Mario Santinami","orcid":"https://orcid.org/0000-0001-8436-4757","observed_orcids":["https://orcid.org/0000-0001-8436-4757"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Santinami","raw_affiliation_strings":["Melanoma and Sarcoma Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma and Sarcoma Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011613484","display_name":"Roberto Patuzzo","orcid":"https://orcid.org/0000-0002-5276-3937","observed_orcids":["https://orcid.org/0000-0002-5276-3937"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Patuzzo","raw_affiliation_strings":["Melanoma and Sarcoma Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma and Sarcoma Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004535372","display_name":"Barbara Vergani","orcid":"https://orcid.org/0000-0002-4389-6324","observed_orcids":["https://orcid.org/0000-0002-4389-6324"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Vergani","raw_affiliation_strings":["Consorzio MIA (Microscopy and Image Analysis), University of Milano-Bicocca, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consorzio MIA (Microscopy and Image Analysis), University of Milano-Bicocca, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085140427","display_name":"Antonello Villa","orcid":"https://orcid.org/0000-0002-3820-8072","observed_orcids":["https://orcid.org/0000-0002-3820-8072"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonello Villa","raw_affiliation_strings":["Consorzio MIA (Microscopy and Image Analysis), University of Milano-Bicocca, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consorzio MIA (Microscopy and Image Analysis), University of Milano-Bicocca, Milano, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114374291","display_name":"Giacomo Manenti","orcid":"https://orcid.org/0000-0002-4887-4482","observed_orcids":["https://orcid.org/0000-0002-4887-4482"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giacomo Manenti","raw_affiliation_strings":["Department of Predictive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Predictive and Preventive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018731144","display_name":"Loredana Cleris","orcid":"https://orcid.org/0000-0001-8778-7931","observed_orcids":["https://orcid.org/0000-0001-8778-7931"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Loredana Cleris","raw_affiliation_strings":["Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074286982","display_name":"Daniele Giardiello","orcid":"https://orcid.org/0000-0002-9005-9430","observed_orcids":["https://orcid.org/0000-0002-9005-9430"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniele Giardiello","raw_affiliation_strings":["Unit of Clinical Epidemiology and Trial Organization, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Clinical Epidemiology and Trial Organization, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043821826","display_name":"Malcolm Ronald Alison","orcid":"https://orcid.org/0000-0002-7348-3387","observed_orcids":["https://orcid.org/0000-0002-7348-3387"]},"institutions":[{"id":"https://openalex.org/I4405264518","display_name":"Barts Cancer Institute","ror":"https://ror.org/0266wrt04","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405264518"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Malcolm Alison","raw_affiliation_strings":["Centre for Tumour Biology, Barts Cancer Institute, Charterhouse Square, London, EC1M 6BQ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Tumour Biology, Barts Cancer Institute, Charterhouse Square, London, EC1M 6BQ, United Kingdom","institution_ids":["https://openalex.org/I4405264518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069765350","display_name":"Licia Rivoltini","orcid":"https://orcid.org/0000-0002-2409-6225","observed_orcids":["https://orcid.org/0000-0002-2409-6225"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Licia Rivoltini","raw_affiliation_strings":["Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]},{"raw_affiliation_string":"Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067882748","display_name":"Chiara Castelli","orcid":"https://orcid.org/0000-0001-6891-8350","observed_orcids":["https://orcid.org/0000-0001-6891-8350"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Chiara Castelli","raw_affiliation_strings":["Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]},{"raw_affiliation_string":"Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000368342","display_name":"Michela Perego","orcid":"https://orcid.org/0000-0002-5671-928X","observed_orcids":["https://orcid.org/0000-0002-5671-928X"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michela Perego","raw_affiliation_strings":["Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]},{"raw_affiliation_string":"Unit of Immunotherapy of Human Tumors, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy","institution_ids":["https://openalex.org/I4210156707"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067882748"],"corresponding_institution_ids":["https://openalex.org/I4210156707"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":2.4619,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.90226131,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"34","issue":"10","first_page":"2449","last_page":"2460"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.656000018119812},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.7260000109672546},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/il-10-receptor-alpha","display_name":"IL-10 receptor alpha","score":0.8149999976158142},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.7699999809265137},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.5839999914169312},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.902999997138977},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.6620000004768372},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9438582062721252},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6342790126800537},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5381575226783752},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.355824738740921}],"mesh":[{"descriptor_ui":"D000066673","descriptor_name":"Cell Self Renewal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019899","descriptor_name":"Paracrine Communication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/stem.2413","doi":"https://doi.org/10.1002/stem.2413","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.2413","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},{"id":"pmid:27301067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27301067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"},{"id":"pmh:oai:boa.unimib.it:10281/119169","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10281/119169","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/172747","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/172747","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cells, 34, 10, pp. 2449-2460","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/172747","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/172747","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cells, 34, 2449 - 2460","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1208639196","display_name":null,"funder_award_id":"CC IG-10615","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"},{"id":"https://openalex.org/F4320338283","display_name":"Office of Experimental Program to Stimulate Competitive Research","ror":"https://ror.org/04k9mqs78"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W28084666","https://openalex.org/W1756614403","https://openalex.org/W1958744278","https://openalex.org/W1958877028","https://openalex.org/W1965124005","https://openalex.org/W1974248849","https://openalex.org/W1983986832","https://openalex.org/W1987664550","https://openalex.org/W1989805762","https://openalex.org/W1990757263","https://openalex.org/W1997806336","https://openalex.org/W2008322756","https://openalex.org/W2008878539","https://openalex.org/W2012717286","https://openalex.org/W2012900885","https://openalex.org/W2014691022","https://openalex.org/W2019188656","https://openalex.org/W2021356485","https://openalex.org/W2023457181","https://openalex.org/W2024145520","https://openalex.org/W2030377822","https://openalex.org/W2030702612","https://openalex.org/W2034279215","https://openalex.org/W2040385253","https://openalex.org/W2043746859","https://openalex.org/W2050605813","https://openalex.org/W2051588629","https://openalex.org/W2056216570","https://openalex.org/W2060185596","https://openalex.org/W2064034345","https://openalex.org/W2064784232","https://openalex.org/W2072569544","https://openalex.org/W2077246243","https://openalex.org/W2079597107","https://openalex.org/W2082538751","https://openalex.org/W2084285057","https://openalex.org/W2091714475","https://openalex.org/W2094793885","https://openalex.org/W2102085111","https://openalex.org/W2103709809","https://openalex.org/W2104666893","https://openalex.org/W2105986003","https://openalex.org/W2106728581","https://openalex.org/W2107554353","https://openalex.org/W2111068327","https://openalex.org/W2112019903","https://openalex.org/W2112467050","https://openalex.org/W2114817620","https://openalex.org/W2118863192","https://openalex.org/W2120668381","https://openalex.org/W2124156632","https://openalex.org/W2129644533","https://openalex.org/W2131078803","https://openalex.org/W2147650118","https://openalex.org/W2150158318","https://openalex.org/W2158731226","https://openalex.org/W2161817637","https://openalex.org/W2164629825","https://openalex.org/W2167886213","https://openalex.org/W6637743059"],"related_works":["https://openalex.org/W4220829123","https://openalex.org/W2154241214","https://openalex.org/W2142277279","https://openalex.org/W3205905006","https://openalex.org/W2069941983","https://openalex.org/W2067816945","https://openalex.org/W4238309690","https://openalex.org/W1981718698","https://openalex.org/W2102265655","https://openalex.org/W1972510488"],"abstract_inverted_index":{"Melanoma":[0,16],"is":[1,232],"a":[2,11,26,33,111],"highly":[3],"heterogeneous":[4],"tumor":[5,40,64,223],"for":[6],"which":[7],"recent":[8],"evidence":[9],"supports":[10],"model":[12],"of":[13,28,56,66,79,82,93,168,177,198,243],"dynamic":[14],"stemness.":[15],"cells":[17,30,87,133],"might":[18],"temporally":[19],"acquire":[20],"tumor-initiating":[21,29],"properties":[22],"or":[23],"switch":[24],"from":[25,63],"status":[27],"(TICs)":[31],"to":[32,95,117,182,185,234,239],"more":[34],"differentiated":[35,86,119,145],"one":[36],"depending":[37],"on":[38,53],"the":[39,54,76,91,178,189,222],"context.":[41],"However,":[42],"factors":[43],"driving":[44],"these":[45,192],"functional":[46,196],"changes":[47],"are":[48],"still":[49],"unknown.":[50],"We":[51,74,101],"focused":[52],"role":[55,226],"cyto/chemokines":[57,94],"in":[58,106,227],"shaping":[59],"TICs":[60,80],"isolated":[61],"directly":[62,202],"specimens":[65],"two":[67],"melanoma":[68,85,132,199,229],"patients,":[69],"namely":[70],"Me14346S":[71],"and":[72,81,88,99,126,134,150,174,206,215],"Me15888S.":[73],"analyzed":[75],"secretion":[77],"profile":[78,114],"their":[83,118],"corresponding":[84],"we":[89],"tested":[90],"ability":[92],"influence":[96,138],"TIC":[97,139,148,152,161,213,218,230],"self-renewal":[98,149,162],"differentiation.":[100,187],"found":[102],"that":[103,195],"TICs,":[104],"grown":[105],"vitro":[107],"as":[108,115,124],"melanospheres,":[109],"had":[110],"complex":[112],"secretory":[113],"compared":[116],"counterparts.":[120],"Some":[121],"factors,":[122,209],"such":[123],"CCL-2":[125],"IL-8,":[127],"also":[128],"produced":[129,156],"by":[130,144,157,171,204],"adherent":[131],"melanocytes":[135],"did":[136],"not":[137],"properties.":[140],"Conversely,":[141],"IL-6,":[142],"released":[143],"cells,":[146],"reduced":[147],"induced":[151],"differentiation":[153],"while":[154],"IL-10,":[155],"Me15888S,":[158],"strongly":[159],"promoted":[160],"through":[163],"paracrine/autocrine":[164],"actions.":[165],"Complete":[166],"neutralization":[167],"IL-10":[169,216],"activity":[170],"gene":[172],"silencing":[173],"antibody-mediated":[175],"blocking":[176],"IL-10R\u03b1":[179],"was":[180],"required":[181],"sensitize":[183],"Me15888S":[184],"IL-6-induced":[186],"For":[188],"first":[190],"time":[191],"results":[193],"show":[194],"heterogeneity":[197],"could":[200],"be":[201],"influenced":[203],"inflammatory":[205],"suppressive":[207],"soluble":[208],"with":[210],"IL-6":[211],"favoring":[212],"differentiation,":[214],"supporting":[217],"self-renewal.":[219],"Thus,":[220],"understanding":[221],"microenvironment":[224],"(TME)":[225],"modulating":[228],"phenotype":[231],"fundamental":[233],"identifying":[235],"novel":[236],"therapeutic":[237],"targets":[238],"achieve":[240],"long-lasting":[241],"regression":[242],"metastatic":[244],"melanoma.":[245],"Stem":[246],"Cells":[247],"2016;34:2449-2460.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}