{"id":"https://openalex.org/W2419954990","doi":null,"title":"Steroid-sparing effect of ketotifen in steroid-dependent asthmatics: a long period evaluation in 12 patients.","display_name":"Steroid-sparing effect of ketotifen in steroid-dependent asthmatics: a long period evaluation in 12 patients.","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2419954990","mag":"2419954990","pmid":"https://pubmed.ncbi.nlm.nih.gov/2834745"},"language":"en","primary_location":{"id":"pmid:2834745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2834745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmatherapeutica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111113655","display_name":"Shiro KASUYA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Kasuya","raw_affiliation_strings":["Department of Internal Medicine, Tohno Hospital, Kani City, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Tohno Hospital, Kani City, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037415809","display_name":"Shum-Ichiro Izumi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Izumi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5527,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.84717772,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"3","first_page":"177","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketotifen","display_name":"ketotifen","score":1.0},{"id":"https://openalex.org/keywords/steroid-sparing-effect","display_name":"steroid-sparing effect","score":0.9580000042915344},{"id":"https://openalex.org/keywords/steroid-dependent-asthma","display_name":"steroid-dependent asthma","score":0.8519999980926514},{"id":"https://openalex.org/keywords/prednisolone-dose-reduction","display_name":"prednisolone dose reduction","score":0.8059999942779541},{"id":"https://openalex.org/keywords/salbutamol","display_name":"salbutamol","score":0.8849999904632568},{"id":"https://openalex.org/keywords/long-term-treatment","display_name":"long-term treatment","score":0.7409999966621399},{"id":"https://openalex.org/keywords/dizziness","display_name":"dizziness","score":0.6629999876022339},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C2780571441","wikidata":"https://www.wikidata.org/wiki/Q2458673","display_name":"Ketotifen","level":3,"score":0.9778048992156982},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7357736825942993},{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.6029902696609497},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.4962208867073059},{"id":"https://openalex.org/C2777394947","wikidata":"https://www.wikidata.org/wiki/Q410358","display_name":"Salbutamol","level":3,"score":0.46032917499542236},{"id":"https://openalex.org/C2776804153","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Corticosteroid","level":2,"score":0.41994157433509827},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.3959723711013794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3587711453437805},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3400578498840332},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.06884366273880005}],"mesh":[{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007665","descriptor_name":"Ketotifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2834745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2834745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmatherapeutica","raw_type":"Journal Article"},{"id":"mag:2419954990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2834745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W267497835","https://openalex.org/W7097598559","https://openalex.org/W2156547646","https://openalex.org/W3144895809","https://openalex.org/W2442011345","https://openalex.org/W2082383832","https://openalex.org/W2010925453","https://openalex.org/W2407512849","https://openalex.org/W2027508870","https://openalex.org/W1967050684"],"abstract_inverted_index":{"An":[0],"open":[1],"pilot":[2],"study":[3],"was":[4,36,109,143,165],"carried":[5],"out":[6],"over":[7],"a":[8,144],"period":[9],"of":[10,20,48,54,66,95,105,120,163,171],"more":[11],"than":[12,89,113,133],"2":[13,46],"years":[14,47],"to":[15,84,128,155,179],"assess":[16],"the":[17,39,52,59,67,76,92,97,103,106,116,136,139,172],"steroid-sparing":[18],"effect":[19],"ketotifen":[21,49,164],"(1":[22],"mg":[23,83,154],"twice":[24],"daily)":[25],"in":[26,64,91,135,147,169],"12":[27,68],"steroid-dependent":[28],"asthmatic":[29],"patients.":[30],"Daily":[31],"steroid":[32,74,150],"consumption":[33,75,119,151],"(prednisolone":[34],"equivalent)":[35,124],"calculated":[37],"for":[38,43],"year":[40,94],"before":[41],"and":[42,45],"1":[44],"treatment":[50],"from":[51,81,126,152],"total":[53],"all":[55,174],"doses":[56],"given":[57],"throughout":[58],"year.":[60],"Results":[61],"showed":[62],"that":[63],"6":[65,140],"patients":[69],"who":[70],"responded":[71],"with":[72,181],"reduced":[73],"mean":[77,99,117,148],"daily":[78,118,149],"dose":[79],"decreased":[80,125],"5.7":[82],"4.1":[85],"mg/day":[86,130],"(p":[87,111,131],"less":[88,112,132],"0.05)":[90],"first":[93],"ketotifen:":[96],"final":[98],"reduction":[100],"rate":[101],"at":[102],"end":[104],"2-year":[107],"trail":[108],"83.6%":[110],"0.005).":[114],"Furthermore,":[115],"beta":[121],"2-stimulants":[122],"(salbutamol":[123],"8.7":[127],"6.2":[129],"0.025)":[134],"responders.":[137],"In":[138],"non-responders,":[141],"there":[142],"slight":[145],"increase":[146],"2.4":[153],"3.0":[156],"mg/day.":[157],"The":[158],"most":[159],"frequently":[160],"reported":[161],"side-effect":[162],"dizziness,":[166],"which":[167],"occurred":[168],"one-third":[170],"patients;":[173],"patients,":[175],"however,":[176],"were":[177],"able":[178],"continue":[180],"treatment.":[182]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
