{"id":"https://openalex.org/W2419781546","doi":"https://doi.org/10.1039/c6mt00058d","title":"The emerging role of lysosomes in copper homeostasis","display_name":"The emerging role of lysosomes in copper homeostasis","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2419781546","doi":"https://doi.org/10.1039/c6mt00058d","mag":"2419781546","pmid":"https://pubmed.ncbi.nlm.nih.gov/27339113"},"language":"en","primary_location":{"id":"doi:10.1039/c6mt00058d","doi":"https://doi.org/10.1039/c6mt00058d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c6mt00058d","pdf_url":null,"source":{"id":"https://openalex.org/S134674912","display_name":"Metallomics","issn_l":"1756-5901","issn":["1756-5901","1756-591X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103447441","display_name":"Elena V. Polishchuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152213","display_name":"Telethon Institute Of Genetics And Medicine","ror":"https://ror.org/04xfdsg27","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210152213","https://openalex.org/I4210154366"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena V. Polishchuk","raw_affiliation_strings":["Telethon Institute of Genetics and Medicine (TIGEM), Via Campi Flegrei 34, Pozzuoli (NA), 80078, Italy. polish@tigem.it","Telethon Institute of Genetics and Medicine (TIGEM), Via Campi Flegrei 34, Pozzuoli (NA), 80078, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Telethon Institute of Genetics and Medicine (TIGEM), Via Campi Flegrei 34, Pozzuoli (NA), 80078, Italy. polish@tigem.it","institution_ids":["https://openalex.org/I4210152213"]},{"raw_affiliation_string":"Telethon Institute of Genetics and Medicine (TIGEM), Via Campi Flegrei 34, Pozzuoli (NA), 80078, Italy","institution_ids":["https://openalex.org/I4210152213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090295114","display_name":"Roman Polishchuk","orcid":"https://orcid.org/0000-0002-7698-1955","observed_orcids":["https://orcid.org/0000-0002-7698-1955"]},"institutions":[{"id":"https://openalex.org/I4210152213","display_name":"Telethon Institute Of Genetics And Medicine","ror":"https://ror.org/04xfdsg27","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210152213","https://openalex.org/I4210154366"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Roman S. Polishchuk","raw_affiliation_strings":["Telethon Institute of Genetics and Medicine (TIGEM), Via Campi Flegrei 34, Pozzuoli (NA), 80078, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Telethon Institute of Genetics and Medicine (TIGEM), Via Campi Flegrei 34, Pozzuoli (NA), 80078, Italy","institution_ids":["https://openalex.org/I4210152213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090295114"],"corresponding_institution_ids":["https://openalex.org/I4210152213"],"apc_list":{"value":2653,"currency":"USD","value_usd":2653},"apc_paid":null,"fwci":0.8848,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.63108454,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"8","issue":"9","first_page":"853","last_page":"862"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/copper-homeostasis","display_name":"copper homeostasis","score":1.0},{"id":"https://openalex.org/keywords/copper-transport","display_name":"copper transport","score":0.6209999918937683},{"id":"https://openalex.org/keywords/metal-homeostasis","display_name":"metal homeostasis","score":0.6679999828338623},{"id":"https://openalex.org/keywords/copper-sequestration","display_name":"copper sequestration","score":0.6079999804496765},{"id":"https://openalex.org/keywords/copper-enzymes","display_name":"copper enzymes","score":0.7540000081062317},{"id":"https://openalex.org/keywords/copper-toxicity","display_name":"copper toxicity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/nutrient-sensing","display_name":"nutrient sensing","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.8135435581207275},{"id":"https://openalex.org/C110455231","wikidata":"https://www.wikidata.org/wiki/Q897788","display_name":"Compartmentalization (fire protection)","level":3,"score":0.7234411239624023},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.7223669290542603},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7174211144447327},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.7025545835494995},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6047648191452026},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5372464656829834},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5182228088378906},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4139196574687958},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.35134822130203247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35118263959884644},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26687920093536377},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000073840","descriptor_name":"Copper-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/c6mt00058d","doi":"https://doi.org/10.1039/c6mt00058d","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c6mt00058d","pdf_url":null,"source":{"id":"https://openalex.org/S134674912","display_name":"Metallomics","issn_l":"1756-5901","issn":["1756-5901","1756-591X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics","raw_type":"journal-article"},{"id":"pmid:27339113","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27339113","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metallomics : integrated biometal science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6106117570","display_name":null,"funder_award_id":"TGM11CB4","funder_id":"https://openalex.org/F4320321179","funder_display_name":"Fondazione Telethon"}],"funders":[{"id":"https://openalex.org/F4320321179","display_name":"Fondazione Telethon","ror":"https://ror.org/04xraxn18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W192250034","https://openalex.org/W266544713","https://openalex.org/W1534985842","https://openalex.org/W1584244824","https://openalex.org/W1605558459","https://openalex.org/W1863296768","https://openalex.org/W1946610952","https://openalex.org/W1965893636","https://openalex.org/W1967868572","https://openalex.org/W1970661950","https://openalex.org/W1972183722","https://openalex.org/W1980774509","https://openalex.org/W1984303321","https://openalex.org/W1986642316","https://openalex.org/W1987628482","https://openalex.org/W1989418680","https://openalex.org/W1990081237","https://openalex.org/W1990729534","https://openalex.org/W1996152690","https://openalex.org/W1996878434","https://openalex.org/W1999253766","https://openalex.org/W2000402876","https://openalex.org/W2010717647","https://openalex.org/W2012499705","https://openalex.org/W2016847333","https://openalex.org/W2020582877","https://openalex.org/W2022855337","https://openalex.org/W2024239842","https://openalex.org/W2026439887","https://openalex.org/W2028445515","https://openalex.org/W2029144698","https://openalex.org/W2029729041","https://openalex.org/W2031504208","https://openalex.org/W2038923126","https://openalex.org/W2038955988","https://openalex.org/W2041143337","https://openalex.org/W2043321552","https://openalex.org/W2047668666","https://openalex.org/W2052607444","https://openalex.org/W2054087588","https://openalex.org/W2057917469","https://openalex.org/W2060062898","https://openalex.org/W2060372741","https://openalex.org/W2071568301","https://openalex.org/W2072383565","https://openalex.org/W2073799621","https://openalex.org/W2074709818","https://openalex.org/W2075968964","https://openalex.org/W2076622939","https://openalex.org/W2078205176","https://openalex.org/W2080982842","https://openalex.org/W2081604003","https://openalex.org/W2083433634","https://openalex.org/W2084225035","https://openalex.org/W2084492467","https://openalex.org/W2088759019","https://openalex.org/W2096747288","https://openalex.org/W2097334193","https://openalex.org/W2097951502","https://openalex.org/W2099905582","https://openalex.org/W2100738632","https://openalex.org/W2103180882","https://openalex.org/W2103644870","https://openalex.org/W2106078939","https://openalex.org/W2110871531","https://openalex.org/W2111712036","https://openalex.org/W2114908128","https://openalex.org/W2118189054","https://openalex.org/W2121334906","https://openalex.org/W2121759452","https://openalex.org/W2125812338","https://openalex.org/W2130002263","https://openalex.org/W2130614540","https://openalex.org/W2132218390","https://openalex.org/W2147519918","https://openalex.org/W2148745060","https://openalex.org/W2157400322","https://openalex.org/W2166118277","https://openalex.org/W2168236445","https://openalex.org/W2168318070","https://openalex.org/W2187002261","https://openalex.org/W2213445198","https://openalex.org/W2268528663","https://openalex.org/W2324557890","https://openalex.org/W4240471350","https://openalex.org/W4244665513"],"related_works":["https://openalex.org/W7220844656","https://openalex.org/W2084225035","https://openalex.org/W1976946953","https://openalex.org/W2080588862","https://openalex.org/W2758064341","https://openalex.org/W2411336830","https://openalex.org/W2352060348","https://openalex.org/W4926351","https://openalex.org/W4412521980","https://openalex.org/W1995066029"],"abstract_inverted_index":{"The":[0],"lysosomal":[1,141],"system":[2,142],"operates":[3],"as":[4,16,143],"a":[5,9,85,144],"focal":[6],"point":[7],"where":[8,71],"number":[10,120],"of":[11,24,28,31,35,87,95,121,139,149,156],"important":[12,97],"physiological":[13],"processes":[14,127,159],"such":[15],"endocytosis,":[17],"autophagy":[18],"and":[19,110,152,162],"nutrient":[20],"sensing":[21],"converge.":[22],"One":[23],"the":[25,33,42,57,69,93,136,140,147,154],"key":[26,157],"functions":[27],"lysosomes":[29,63],"consists":[30],"regulating":[32],"metabolism/homeostasis":[34],"metals.":[36],"Metal-containing":[37],"components":[38,79],"are":[39,74,90],"carried":[40],"to":[41,54,64,68,84,114],"lysosome":[43,58],"through":[44],"incoming":[45],"membrane":[46],"flows,":[47],"while":[48],"numerous":[49],"transporters":[50],"allow":[51],"metal":[52,66,72],"ions":[53,73],"move":[55],"across":[56],"membrane.":[59],"These":[60],"properties":[61],"enable":[62],"direct":[65],"fluxes":[67],"sites":[70],"either":[75],"used":[76],"by":[77],"cellular":[78],"or":[80],"sequestered.":[81],"Copper":[82],"belongs":[83],"group":[86],"metals":[88],"that":[89,125,134],"essential":[91],"for":[92,146,153],"activity":[94],"vitally":[96],"enzymes,":[98],"although":[99],"it":[100],"is":[101],"toxic":[102],"when":[103],"in":[104,160],"excess.":[105],"Thus,":[106],"copper":[107],"uptake,":[108],"supply":[109],"intracellular":[111],"compartmentalization":[112],"have":[113,123],"be":[115],"tightly":[116],"regulated.":[117],"An":[118],"increasing":[119],"publications":[122],"indicated":[124],"these":[126],"involve":[128],"lysosomes.":[129],"Here":[130],"we":[131],"review":[132],"studies":[133],"reveal":[135],"expanding":[137],"role":[138],"hub":[145],"control":[148],"Cu":[150],"homeostasis":[151],"regulation":[155],"Cu-dependent":[158],"health":[161],"disease.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}