{"id":"https://openalex.org/W2419672017","doi":null,"title":"Short-time rabbit model of endotoxin-induced hypercoagulability.","display_name":"Short-time rabbit model of endotoxin-induced hypercoagulability.","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W2419672017","mag":"2419672017","pmid":"https://pubmed.ncbi.nlm.nih.gov/8569153"},"language":"en","primary_location":{"id":"pmid:8569153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8569153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory animal science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032346051","display_name":"Scherer Ru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R U Scherer","raw_affiliation_strings":["Institute of Anesthesiology, University Hospital, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anesthesiology, University Hospital, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039335780","display_name":"Reiner M. Giebler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M Giebler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"U Schmidt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Schmidt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"D Paar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Paar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111592605","display_name":"Th. W\u00fcst","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T W\u00fcst","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048184037","display_name":"P. Spangenberg","orcid":"https://orcid.org/0000-0003-2799-276X","observed_orcids":["https://orcid.org/0000-0003-2799-276X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Spangenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Militzer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Militzer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H Hirche","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Hirche","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112170850","display_name":"Kox Wj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W J Kox","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2119,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.55914089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"45","issue":"5","first_page":"538","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.9599999785423279},{"id":"https://openalex.org/keywords/disseminated-intravascular-coagulation","display_name":"disseminated intravascular coagulation","score":0.984000027179718},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.9010000228881836},{"id":"https://openalex.org/keywords/coagulation-cascade","display_name":"coagulation cascade","score":0.7979999780654907},{"id":"https://openalex.org/keywords/anticoagulants","display_name":"anticoagulants","score":0.9340000152587891},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/tracheostomy","display_name":"tracheostomy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/fibrin-deposition","display_name":"fibrin deposition","score":0.7369999885559082},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.6779999732971191},{"id":"https://openalex.org/keywords/thromboelastography","display_name":"thromboelastography","score":0.8019999861717224},{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":0.7829999923706055},{"id":"https://openalex.org/keywords/factor-xiii","display_name":"factor XIII","score":0.800000011920929},{"id":"https://openalex.org/keywords/thrombin-time","display_name":"thrombin time","score":0.42899999022483826},{"id":"https://openalex.org/keywords/activated-partial-thromboplastin-time","display_name":"activated partial thromboplastin time","score":0.8389999866485596}],"concepts":[{"id":"https://openalex.org/C2778261982","wikidata":"https://www.wikidata.org/wiki/Q1755136","display_name":"Partial thromboplastin time","level":3,"score":0.7979162931442261},{"id":"https://openalex.org/C2780434524","wikidata":"https://www.wikidata.org/wiki/Q1144385","display_name":"Prothrombin time","level":2,"score":0.6802257299423218},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.6634603142738342},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.654387354850769},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6525863409042358},{"id":"https://openalex.org/C2780077467","wikidata":"https://www.wikidata.org/wiki/Q2520736","display_name":"Thrombin time","level":4,"score":0.5880957841873169},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.5737670063972473},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.5409184098243713},{"id":"https://openalex.org/C2778734968","wikidata":"https://www.wikidata.org/wiki/Q823027","display_name":"Disseminated intravascular coagulation","level":2,"score":0.5239217877388},{"id":"https://openalex.org/C144594695","wikidata":"https://www.wikidata.org/wiki/Q6153218","display_name":"Thromboplastin","level":3,"score":0.5237921476364136},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5170077085494995},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5166795253753662},{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.45636600255966187},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.4521012306213379},{"id":"https://openalex.org/C2777257755","wikidata":"https://www.wikidata.org/wiki/Q3493813","display_name":"Tidal volume","level":3,"score":0.4118134081363678},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34111616015434265},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.28915172815322876},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.27627599239349365},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25991976261138916}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001779","descriptor_name":"Blood Coagulation Factors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004211","descriptor_name":"Disseminated Intravascular Coagulation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004211","descriptor_name":"Disseminated Intravascular Coagulation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8569153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8569153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory animal science","raw_type":"Journal Article"},{"id":"mag:2419672017","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8569153","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2407357665","https://openalex.org/W2352231045","https://openalex.org/W2003334412","https://openalex.org/W2045596948","https://openalex.org/W3147394487","https://openalex.org/W2410996911","https://openalex.org/W1980659802","https://openalex.org/W2109900910","https://openalex.org/W4313068991","https://openalex.org/W2027852110"],"abstract_inverted_index":{"We":[0,158],"describe":[1],"a":[2,80,178],"short-time":[3,162],"endotoxin-induced":[4,220],"rabbit":[5],"model":[6,163,180,209],"of":[7,12,20,92,113,135,164,197,204,213,216],"hypercoagulability":[8,165],"for":[9],"the":[10,13,17,121,136,151,183,186,189,205,211],"study":[11,212],"coagulation":[14,21,217],"cascade":[15],"and":[16,32,44,69,74,89,99,101,115,140,153,174,188,199],"therapeutic":[18,214],"effects":[19,215],"inhibitors.":[22],"Cardiorespiratory":[23],"function":[24],"was":[25,125,148],"maintained":[26],"in":[27,120,128,150,166,181],"rabbits":[28,167],"under":[29],"general":[30],"anesthesia":[31],"standardized":[33],"mechanical":[34,175],"ventilation":[35,176],"(tidal":[36],"volume,":[37],"6":[38],"ml/kg;":[39],"60":[40],"breaths/min)":[41],"via":[42],"tracheostomy":[43],"low-dose":[45],"inotropic":[46],"support.":[47],"Coagulation":[48],"parameters":[49,112],"such":[50],"as":[51],"prothrombin":[52],"time,":[53,57,59],"activated":[54],"partial":[55],"thromboplastin":[56],"thrombin":[58],"fibrinogen":[60],"concentration,":[61],"platelet":[62,75],"count,":[63],"fibrin":[64,146],"monomers,":[65],"D-dimers,":[66],"antithrombin":[67],"III":[68],"factor":[70],"XIII":[71],"activities,":[72],"thrombelastography,":[73],"aggregometry":[76],"were":[77,107,142,192],"measured":[78],"during":[79],"4-h":[81],"period":[82],"after":[83],"sequential":[84],"double":[85],"endotoxin":[86,198],"administration":[87,196],"(80":[88],"40":[90],"micrograms/kg":[91],"body":[93],"weight,":[94],"intravenously).":[95],"Mean":[96],"arterial":[97,100],"pressure":[98],"central":[102],"venous":[103],"blood":[104],"gas":[105],"tensions":[106],"monitored.":[108],"Global":[109],"clotting,":[110],"activation":[111],"coagulation,":[114],"leukocyte":[116],"count":[117],"deteriorated":[118],"significantly":[119],"endotoxin-treated":[122,190],"animals":[123,191],"but":[124],"mainly":[126],"unaltered":[127],"controls":[129,187],"(P":[130,155],"<":[131,156],"0.05).":[132],"Tissue":[133],"specimens":[134],"lungs,":[137],"liver,":[138],"brain,":[139],"kidneys":[141],"examined.":[143],"Endotoxin-induced,":[144],"disseminated":[145,170],"deposition":[147],"found":[149],"lungs":[152],"liver":[154],"0.01).":[157],"conclude":[159],"that":[160],"this":[161],"reliably":[168],"induced":[169],"intravascular":[171],"coagulation.":[172],"Tracheostomy":[173],"provided":[177],"reproducible":[179],"which":[182],"differences":[184],"between":[185],"exclusively":[193],"due":[194],"to":[195,201],"not":[200],"unforeseen":[202],"complications":[203],"respiratory":[206],"system.":[207],"This":[208],"allows":[210],"inhibitors":[218],"on":[219],"changes.":[221]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
