{"id":"https://openalex.org/W2419643103","doi":null,"title":"The therapeutic effect of theophylline in mild obstructive sleep Apnea/Hypopnea syndrome: results of repeated measurements with portable recording devices at home.","display_name":"The therapeutic effect of theophylline in mild obstructive sleep Apnea/Hypopnea syndrome: results of repeated measurements with portable recording devices at home.","publication_year":2000,"publication_date":"2000-09-18","ids":{"openalex":"https://openalex.org/W2419643103","mag":"2419643103","pmid":"https://pubmed.ncbi.nlm.nih.gov/11003974"},"language":"en","primary_location":{"id":"pmid:11003974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11003974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medical research","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015206530","display_name":"Holger Hein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140903","display_name":"LungenClinic Grosshansdorf","ror":"https://ror.org/041wfjw90","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210140903"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Hein","raw_affiliation_strings":["Krankenhaus Grosshansdorf, Zentrum f\u00fcr Pneumologie und Thoraxchirurgie, W\u00f6hrendamm 80, D-22927 Grosshansdorf, Germany. Holger.Hein@T-online.de","Krankenhaus Grosshansdorf, Zentrum f\u00fcr Pneumologie und Thoraxchirurgie, W\u00f6hrendamm 80, D-22927 Grosshansdorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krankenhaus Grosshansdorf, Zentrum f\u00fcr Pneumologie und Thoraxchirurgie, W\u00f6hrendamm 80, D-22927 Grosshansdorf, Germany. Holger.Hein@T-online.de","institution_ids":["https://openalex.org/I4210140903"]},{"raw_affiliation_string":"Krankenhaus Grosshansdorf, Zentrum f\u00fcr Pneumologie und Thoraxchirurgie, W\u00f6hrendamm 80, D-22927 Grosshansdorf, Germany","institution_ids":["https://openalex.org/I4210140903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015489574","display_name":"G Behnke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Behnke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007448874","display_name":"R A J\u00f6rres","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R A J\u00f6rres","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091839306","display_name":"HELGO MAGNUSSEN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Magnussen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6445,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.68303231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"5","issue":"9","first_page":"391","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/theophylline","display_name":"theophylline","score":0.9990000128746033},{"id":"https://openalex.org/keywords/obstructive-sleep-apnea-hypopnea-syndrome","display_name":"obstructive sleep apnea-hypopnea syndrome","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mild-sleep-apnea","display_name":"mild sleep apnea","score":0.9449999928474426},{"id":"https://openalex.org/keywords/apnea-hypopnea-index","display_name":"apnea-hypopnea index","score":0.9959999918937683},{"id":"https://openalex.org/keywords/night-to-night-variability","display_name":"night-to-night variability","score":0.9539999961853027},{"id":"https://openalex.org/keywords/home-sleep-monitoring","display_name":"home sleep monitoring","score":0.7749999761581421},{"id":"https://openalex.org/keywords/posture","display_name":"posture","score":0.609000027179718},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.8769999742507935},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8109731674194336},{"id":"https://openalex.org/C2778095195","wikidata":"https://www.wikidata.org/wiki/Q407308","display_name":"Theophylline","level":2,"score":0.7396785020828247},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7227122187614441},{"id":"https://openalex.org/C2777711342","wikidata":"https://www.wikidata.org/wiki/Q957217","display_name":"Hypopnea","level":4,"score":0.7165946960449219},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6979085803031921},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.685189425945282},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.5876230597496033},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.5166082978248596},{"id":"https://openalex.org/C2776377968","wikidata":"https://www.wikidata.org/wiki/Q618736","display_name":"Apnea\u2013hypopnea index","level":4,"score":0.46676820516586304},{"id":"https://openalex.org/C125567185","wikidata":"https://www.wikidata.org/wiki/Q3267428","display_name":"Supine position","level":2,"score":0.4191133975982666},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.3792445659637451},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23949626088142395},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001993","descriptor_name":"Bronchodilator Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004864","descriptor_name":"Equipment and Supplies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010045","descriptor_name":"Outpatients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013806","descriptor_name":"Theophylline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11003974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11003974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medical research","raw_type":"Clinical Trial"},{"id":"mag:2419643103","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11003974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2356504004","https://openalex.org/W2041070476","https://openalex.org/W1982431300","https://openalex.org/W2465206195","https://openalex.org/W2087572757","https://openalex.org/W1954995557","https://openalex.org/W2074069624","https://openalex.org/W2413949090","https://openalex.org/W2325281910","https://openalex.org/W2035196242"],"abstract_inverted_index":{"Theophylline":[0,190],"has":[1,28],"been":[2,29],"recommended":[3],"in":[4,11,75,96,115,126],"the":[5,35,45,56,60],"literature":[6],"as":[7],"a":[8,69,97,121,192],"therapeutic":[9],"option":[10],"mild":[12,15,178],"OSAHS.":[13],"In":[14,177],"obstructive":[16],"sleep":[17,41,71,183],"apnea/hypopnea":[18,42],"syndrome":[19],"(OSAHS),":[20],"night-to-night":[21,149],"variability":[22,58,150],"of":[23,25,37,40,47,59,145,151,170,182],"parameters":[24,43],"sleep-disordered":[26],"breathing":[27,185],"determined":[30],"rarely,":[31],"we":[32,54,119],"therefore":[33],"compared":[34],"results":[36],"serial":[38],"measurements":[39,181],"under":[44],"effects":[46],"placebo":[48,93,118],"and":[49,165,173],"theophylline.":[50],"To":[51],"this":[52],"end,":[53],"measured":[55,105],"individual":[57],"apnea-hypopnea":[61],"index":[62],"(AHI)":[63],"for":[64],"seven":[65,129],"consecutive":[66],"nights":[67],"using":[68],"portable":[70],"apnea":[72],"recording":[73],"device,":[74],"14":[76],"subjects":[77],"(2":[78],"women,":[79],"12":[80],"men,":[81],"mean":[82,127],"age":[83],"+/-":[84,88,109,135,139,159],"[standard":[85],"deviation]":[86],"50":[87],"8":[89],"years),":[90],"treated":[91],"with":[92,117],"or":[94],"theophylline":[95,113],"double":[98],"blind,":[99],"randomized":[100],"crossover":[101],"fashion,":[102],"whose":[103],"polysomnographically":[104],"AHI":[106,131,152],"was":[107,143,155],"13":[108],"5":[110],"/hour.":[111],"Under":[112],"treatment":[114],"comparison":[116],"observed":[120],"small":[122,193],"but":[123,194],"significant":[124],"decrease":[125],"(of":[128],"days)":[130],"at":[132,153],"home":[133,154],"(9.2":[134],"7.7":[136],"to":[137,167,198],"6.7":[138],"6.1":[140],"/hour),":[141],"which":[142],"independent":[144,169],"body":[146,171],"position.":[147],"The":[148],"high":[156],"(9.":[157],"2":[158],"8.9":[160],"/hour;":[161],"range:":[162],"0-31.4":[163],"/hour)":[164],"proved":[166],"be":[168,188],"position":[172],"alcohol":[174],"consumption.":[175],"-":[176],"OSAHS,":[179],"repeated":[180],"related":[184],"events":[186],"should":[187],"performed.":[189],"showed":[191],"clinically":[195],"insignificant":[196],"potencial":[197],"reduce":[199],"AHI.":[200]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}