{"id":"https://openalex.org/W2419495491","doi":"https://doi.org/10.1385/1-59259-323-2:329","title":"Angiogenesis, Metastasis, and Lung Cancer: An Overview","display_name":"Angiogenesis, Metastasis, and Lung Cancer: An Overview","publication_year":2003,"publication_date":"2003-11-15","ids":{"openalex":"https://openalex.org/W2419495491","doi":"https://doi.org/10.1385/1-59259-323-2:329","mag":"2419495491","pmid":"https://pubmed.ncbi.nlm.nih.gov/12415706"},"language":"en","primary_location":{"id":"doi:10.1385/1-59259-323-2:329","doi":"https://doi.org/10.1385/1-59259-323-2:329","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59259-323-2:329","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4244266008","display_name":"Lung Cancer"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074185199","display_name":"Amir Onn","orcid":"https://orcid.org/0000-0002-6602-0405","observed_orcids":["https://orcid.org/0000-0002-6602-0405"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amir Onn","raw_affiliation_strings":["Department of Thoracic/Head and Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA","Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic/Head and Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008593691","display_name":"Roy S. Herbst","orcid":"https://orcid.org/0000-0003-2535-5847","observed_orcids":["https://orcid.org/0000-0003-2535-5847"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy S. Herbst","raw_affiliation_strings":["Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.8761,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.76770115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"74","issue":null,"first_page":"329","last_page":"348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.996999979019165},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tumor-blood-supply","display_name":"tumor blood supply","score":0.7279999852180481},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/angiogenesis-regulation","display_name":"angiogenesis regulation","score":0.5699999928474426},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6340000033378601},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.9483237266540527},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7130452394485474},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.6067489981651306},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5743012428283691},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5151392221450806},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.478987455368042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.458671897649765},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.43657582998275757},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4132433533668518},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37471339106559753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3536568582057953},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3314412832260132},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26581162214279175}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1385/1-59259-323-2:329","doi":"https://doi.org/10.1385/1-59259-323-2:329","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59259-323-2:329","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer","raw_type":"book-chapter"},{"id":"pmid:12415706","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12415706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W580600693","https://openalex.org/W1489873347","https://openalex.org/W1573363574","https://openalex.org/W1583164992","https://openalex.org/W1592202036","https://openalex.org/W1787737644","https://openalex.org/W1796205058","https://openalex.org/W1913061990","https://openalex.org/W1918337600","https://openalex.org/W1970730148","https://openalex.org/W1970847065","https://openalex.org/W1970909475","https://openalex.org/W1978139448","https://openalex.org/W1980626129","https://openalex.org/W1985727076","https://openalex.org/W2000000541","https://openalex.org/W2004781757","https://openalex.org/W2005316524","https://openalex.org/W2005786175","https://openalex.org/W2009070960","https://openalex.org/W2009588945","https://openalex.org/W2012255417","https://openalex.org/W2039410387","https://openalex.org/W2048255903","https://openalex.org/W2048397453","https://openalex.org/W2059533629","https://openalex.org/W2062594120","https://openalex.org/W2072928113","https://openalex.org/W2090032922","https://openalex.org/W2091618582","https://openalex.org/W2093915058","https://openalex.org/W2102575656","https://openalex.org/W2111033200","https://openalex.org/W2113257521","https://openalex.org/W2114072364","https://openalex.org/W2116161064","https://openalex.org/W2119615201","https://openalex.org/W2122458965","https://openalex.org/W2126684945","https://openalex.org/W2128853803","https://openalex.org/W2130040222","https://openalex.org/W2130461015","https://openalex.org/W2131798870","https://openalex.org/W2132067697","https://openalex.org/W2135599791","https://openalex.org/W2135638162","https://openalex.org/W2143408828","https://openalex.org/W2150048971","https://openalex.org/W2156144595","https://openalex.org/W2160926771","https://openalex.org/W2170201138","https://openalex.org/W2319962899","https://openalex.org/W2340893063","https://openalex.org/W2408566918","https://openalex.org/W2418826466","https://openalex.org/W2418840633","https://openalex.org/W2419571328","https://openalex.org/W2440788947"],"related_works":["https://openalex.org/W20143481","https://openalex.org/W61420045","https://openalex.org/W1493284995","https://openalex.org/W7057376197","https://openalex.org/W1432819791","https://openalex.org/W202072543","https://openalex.org/W4316672136","https://openalex.org/W2411300115","https://openalex.org/W141412051","https://openalex.org/W2170879329"],"abstract_inverted_index":{"Tumor":[0],"angiogenesis":[1,12,177,187,215],"enables":[2],"a":[3,101,203],"pre-existing":[4],"tumor":[5,186],"to":[6,32,144],"grow":[7,106],"and":[8,45,77,179,188,208,216,222,230],"metastasize.":[9,112],"The":[10,218],"term":[11],"designates":[13],"development":[14,189],"of":[15,36,47,96,117,154,176,190,202,206,214,236],"new":[16,37,97],"blood":[17,38,59,98,102],"vessels":[18],"from":[19,138,141],"preexisting":[20],"vasculature.":[21],"Goldman":[22],"(":[23,62,131,147,170],"1)":[24],",":[25],"in":[26,65,89,165,183,185,193,199],"1907,":[27],"was":[28],"the":[29,34,82,94,115,159,174,180,194,200,212,234],"fi":[30,167],"rst":[31],"describe":[33],"formation":[35,95],"vessels,":[39],"i.e.,":[40],"angiogenesis,":[41],"around":[42],"tumors.":[43],"Growth":[44],"survival":[46],"normal":[48],"cells,":[49],"as":[50,52],"well":[51],"tumors,":[53,68],"are":[54,84],"dependent":[55],"on":[56],"an":[57],"adequate":[58],"supply.":[60],"Folkman":[61],"2)":[63],"suggested":[64],"1971":[66],"that":[67,166,210],"like":[69],"any":[70],"other":[71],"tissue,":[72],"can":[73],"only":[74],"receive":[75],"oxygen":[76],"nutrients":[78],"by":[79,227],"diffusion":[80],"if":[81],"tumors":[83,104,229],"smaller":[85],"than":[86],"1-2":[87],"mm":[88],"diameter.":[90],"Further":[91],"growth":[92],"necessitates":[93],"vessels.":[99],"Without":[100],"supply,":[103],"cannot":[105],"beyond":[107],"this":[108],"critical":[109],"size,":[110],"or":[111,127],"However,":[113],"at":[114],"time":[116],"their":[118],"initial":[119],"treatment,":[120],"most":[121,136],"patients":[122],"with":[123],"cancer":[124,139,155],"have":[125],"clinically":[126],"microscopically":[128],"detectable":[129],"metastases":[130,142],"3)":[132,148],".":[133,149],"In":[134],"addition,":[135],"deaths":[137],"result":[140],"resistant":[143],"conventional":[145],"therapy":[146],"Understanding":[150],"these":[151],"fundamental":[152],"principles":[153],"biology":[156],"has":[157],"been":[158],"main":[160],"drive":[161],"for":[162],"comprehensive":[163],"research":[164,178,197],"eld.":[168],"Kerbel":[169],"4)":[171],"recently":[172],"discussed":[173],"history":[175],"striking":[181],"increase":[182],"interest":[184],"anti-angiogenesis":[191],"drugs":[192],"1990s.":[195],"This":[196],"resulted":[198],"discovery":[201],"growing":[204],"number":[205],"genes":[207],"molecules":[209,225],"regulate":[211],"physiology":[213],"metastasis.":[217],"balance":[219],"between":[220],"positive":[221],"negative":[223],"regulatory":[224],"released":[226],"both":[228],"host":[231],"cells":[232],"mediates":[233],"induction":[235],"angiogenesis.":[237]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}