{"id":"https://openalex.org/W2419251361","doi":null,"title":"Why are estrogen-receptor-negative breast cancers more aggressive than the estrogen-receptor-positive breast cancers?","display_name":"Why are estrogen-receptor-negative breast cancers more aggressive than the estrogen-receptor-positive breast cancers?","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2419251361","mag":"2419251361","pmid":"https://pubmed.ncbi.nlm.nih.gov/7657526"},"language":"en","primary_location":{"id":"pmid:7657526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7657526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Invasion & metastasis","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013951187","display_name":"Sheikh Ms","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4387153574","display_name":"Universit\u00e9 Montpellier 1","ror":"https://ror.org/0227fbx80","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M S Sheikh","raw_affiliation_strings":["Universit\u00e9 de Montpellier 1, Facult\u00e9 de M\u00e9decine, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Hormones et Cancer (U 148), France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Montpellier 1, Facult\u00e9 de M\u00e9decine, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Hormones et Cancer (U 148), France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4387153574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109007913","display_name":"Marcel Garcia","orcid":"https://orcid.org/0000-0002-6997-9654","observed_orcids":["https://orcid.org/0000-0002-6997-9654"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Garcia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060814256","display_name":"Pascal Pujol","orcid":"https://orcid.org/0000-0001-8315-4715","observed_orcids":["https://orcid.org/0000-0001-8315-4715"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Pujol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039968524","display_name":"Joseph A. Fontana","orcid":"https://orcid.org/0000-0003-3829-3358","observed_orcids":["https://orcid.org/0000-0003-3829-3358"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Fontana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034959128","display_name":"Henri Rochefort","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Rochefort","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4188,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.57051736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"14","issue":"1-6","first_page":"329","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-negative-breast-cancer","display_name":"estrogen receptor-negative breast cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.9470000267028809},{"id":"https://openalex.org/keywords/breast-cancer-aggressiveness","display_name":"breast cancer aggressiveness","score":0.8690000176429749},{"id":"https://openalex.org/keywords/hormone-resistance","display_name":"hormone resistance","score":0.8889999985694885},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.753000020980835},{"id":"https://openalex.org/keywords/estrogen-receptor-activation","display_name":"estrogen receptor activation","score":0.5580000281333923},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8700000047683716},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.7993083000183105},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7326995730400085},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6174227595329285},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5817066431045532},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5383390784263611},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49175456166267395},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44955453276634216},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.4439026713371277},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.4344331622123718},{"id":"https://openalex.org/C96307122","wikidata":"https://www.wikidata.org/wiki/Q15329133","display_name":"Estrogen receptor beta","level":5,"score":0.4279422461986542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4068053662776947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3257138729095459},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3036981225013733},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2886049449443817},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.051120489835739136}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009376","descriptor_name":"Neoplasms, Hormone-Dependent","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7657526","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7657526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Invasion & metastasis","raw_type":"Journal Article"},{"id":"mag:2419251361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7657526","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2244648399","https://openalex.org/W1966568300","https://openalex.org/W2182195505","https://openalex.org/W4253364597","https://openalex.org/W1554024426","https://openalex.org/W40384548","https://openalex.org/W190916212","https://openalex.org/W2132268003","https://openalex.org/W34411024","https://openalex.org/W2009504099"],"abstract_inverted_index":{"It":[0],"is":[1],"well":[2],"established":[3],"that":[4],"some":[5],"of":[6,26,38,51,55,68,88,90],"the":[7,36,52,56,65,85,91],"hormone-resistant":[8],"breast":[9,30,93],"cancers":[10,31],"lack":[11],"functional":[12],"estrogen":[13,24],"receptor":[14],"(ER)":[15],"and":[16,60,75],"exhibit":[17],"a":[18],"more":[19],"aggressive":[20,43],"metastatic":[21],"phenotype.":[22],"The":[23,49],"activation":[25,37],"ER":[27,57],"in":[28,71],"ER-positive":[29],"enhances":[32],"their":[33,47],"aggressiveness,":[34],"while":[35],"exogenously":[39],"introduced":[40],"ERs":[41],"into":[42],"ER-negative":[44,92],"cells":[45],"diminishes":[46],"aggressiveness.":[48],"basis":[50],"protective":[53],"effect":[54],"appears":[58],"complex":[59],"could":[61],"be":[62],"due":[63],"to":[64],"altered":[66],"expression":[67],"genes":[69],"involved":[70],"cell":[72],"proliferation,":[73],"differentiation":[74],"invasiveness.":[76],"In":[77],"this":[78],"review,":[79],"we":[80],"propose":[81],"different":[82],"mechanisms":[83],"for":[84],"higher":[86],"aggressiveness":[87],"most":[89],"cancers.":[94]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}